Zobrazeno 1 - 10
of 149
pro vyhledávání: '"John F. Timms"'
Autor:
Nuno R. Nené, Alexander Ney, Tatiana Nazarenko, Oleg Blyuss, Harvey E. Johnston, Harry J. Whitwell, Eva Sedlak, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Eithne Costello, William Greenhalf, Ian Jacobs, Usha Menon, Justin Hsuan, Stephen P. Pereira, Alexey Zaikin, John F. Timms
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Nené et al. construct machine learning models based on serum protein biomarker data to detect pancreatic ductal adenocarcinoma in a nested case-control study from the UKCTOCS cohort. Their ensemble modelling approach outperforms existing combination
Externí odkaz:
https://doaj.org/article/7cece6036b8243379037823c6a8d4e33
Autor:
Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J. Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J. Lippert, Elisa T. Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B. Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J. Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S. Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B. Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J. Porteous, Riccardo E. Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A. Keller, Ivan Tancevski, John F. Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, Florian Kurth, Markus Ralser
Publikováno v:
PLOS Digital Health, Vol 1, Iss 1 (2022)
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited per
Externí odkaz:
https://doaj.org/article/ca9c7a2e20b1488b8dd4b7e2dbf10ad7
Autor:
Lucy Oldfield, Anthony Evans, Rohith Gopala Rao, Claire Jenkinson, Tejpal Purewal, Eftychia E. Psarelli, Usha Menon, John F. Timms, Stephen P. Pereira, Paula Ghaneh, William Greenhalf, Christopher Halloran, Eithne Costello
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103802- (2022)
Summary: Background: Screening for pancreatic ductal adenocarcinoma (PDAC) in populations at high risk is recommended. Individuals with new-onset type 2 diabetes mellitus (NOD) are the largest high-risk group for PDAC. To facilitate screening, we sou
Externí odkaz:
https://doaj.org/article/ea0b8398fda14acd80e2711673230426
Autor:
Stella Irungu, Dimitrios Mavrelos, Jenny Worthington, Oleg Blyuss, Ertan Saridogan, John F. Timms
Publikováno v:
Clinical Proteomics, Vol 16, Iss 1, Pp 1-16 (2019)
Abstract Background Endometriosis is a common gynaecological disorder affecting 5–10% of women of reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis is through laparoscopy, exposing patients to potential
Externí odkaz:
https://doaj.org/article/e931bed01bb64d7abb83d8872cc71e97
Autor:
Jenna Scotcher, Oleksandra Prysyazhna, Andrii Boguslavskyi, Kornel Kistamas, Natasha Hadgraft, Eva D. Martin, Jenny Worthington, Olena Rudyk, Pedro Rodriguez Cutillas, Friederike Cuello, Michael J. Shattock, Michael S. Marber, Maria R. Conte, Adam Greenstein, David J. Greensmith, Luigi Venetucci, John F. Timms, Philip Eaton
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The stroke volume of the heart increases in response to an increase in the blood volume filling the heart. Here the authors reveal that this coordinated process is mediated in part by oxidative activation of the protein kinase G Iα, which phosphoryl
Externí odkaz:
https://doaj.org/article/03ace94ba067478fa8463d2ab1ace41b
Autor:
Aleksandra Gentry-Maharaj, Oleg Blyuss, Andy Ryan, Matthew Burnell, Chloe Karpinskyj, Richard Gunu, Jatinderpal K. Kalsi, Anne Dawnay, Ines P. Marino, Ranjit Manchanda, Karen Lu, Wei-Lei Yang, John F. Timms, Max Parmar, Steven J. Skates, Robert C. Bast, Ian J. Jacobs, Alexey Zaikin, Usha Menon
Publikováno v:
Cancers, Vol 12, Iss 7, p 1931 (2020)
Longitudinal CA125 algorithms are the current basis of ovarian cancer screening. We report on longitudinal algorithms incorporating multiple markers. In the multimodal arm of United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS), 5
Externí odkaz:
https://doaj.org/article/f457c707fbfe4183ab59cf5bfe689589
Autor:
Shibu Krishnan, Harry J. Whitwell, Joy Cuenco, Aleksandra Gentry-Maharaj, Usha Menon, Stephen P. Pereira, Marco Gaspari, John F. Timms
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2670 (2017)
Biomarkers for the early detection of pancreatic cancer are urgently needed. The aim of this pilot study was to evaluate changes in serum N-glycoproteins and their glycosylation status prior to clinical presentation of pancreatic cancer that may be p
Externí odkaz:
https://doaj.org/article/60388bddca554cdf89d6a2ac885d4ece
Autor:
Eithne Costello, John P. Neoptolemos, John F. Timms, Robert Sutton, William Greenhalf, B. Kevin Park, David A. Tuveson, Stephen P. Pereira, Fiona Campbell, Trevor Cox, Usha Menon, Ian J. Jacobs, Evangelia-O Fourkala, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Darragh P. O'Brien, Rosalind E. Jenkins, Lucy Oldfield, Anthony Evans, Victoria L. Elliott, Claire Jenkinson
Detection of CA1-9 by ELISA in (A) individual time to diagnosis groups and (B) diagnosed samples and controls.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19096ab0e1975897f554b811427938a4
https://doi.org/10.1158/1078-0432.22459275.v1
https://doi.org/10.1158/1078-0432.22459275.v1
Autor:
Eithne Costello, John P. Neoptolemos, John F. Timms, Robert Sutton, William Greenhalf, B. Kevin Park, David A. Tuveson, Stephen P. Pereira, Fiona Campbell, Trevor Cox, Usha Menon, Ian J. Jacobs, Evangelia-O Fourkala, Aleksandra Gentry-Maharaj, Sophia Apostolidou, Darragh P. O'Brien, Rosalind E. Jenkins, Lucy Oldfield, Anthony Evans, Victoria L. Elliott, Claire Jenkinson
Peptides and their fragment ions used in MRM assays for TSP-1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82586653ba68850b11189fca847fbfd2
https://doi.org/10.1158/1078-0432.22459269.v1
https://doi.org/10.1158/1078-0432.22459269.v1
Autor:
Eithne Costello, John P. Neoptolemos, William Greenhalf, Christopher Halloran, John F. Timms, Phoebe A. Phillips, Quentin Nunes, Rebecca Dawson, Mehdi Jalali, Milton Ashworth, Triantafillos Liloglou, Pedro A. Perez-Mancera, Zipeng Lu, Timothy Andrews, Fiona Campbell, Frances E. Oldfield, Sarah Brumskill, Brian Lane, Anthony Evans, Lawrence N. Barrera
Patient characteristics of UoL serum sample cohorts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e57539fda1e0c0724f441e7808f996
https://doi.org/10.1158/0008-5472.22424308.v1
https://doi.org/10.1158/0008-5472.22424308.v1