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pro vyhledávání: '"John F. Tallman"'
Autor:
John F Tallman
Publikováno v:
Brain Research Reviews. 31:385-390
The development of the current generation of antipsychotics has depended on animal, biochemical and pharmacological models of the action of drugs discovered serentipidously. They have focused on the dopamine hypothesis of schizophrenia. More recent s
Publikováno v:
The Neuroscientist. 5:351-361
Recent advances in the molecular biology of GABAA receptors is described along with the impact of these advances on drug design for this family of receptors. The receptor molecular structure is described with particular emphasis on the sites to which
Autor:
John F Tallman
Publikováno v:
Neuropsychopharmacology. 20:99-105
Rapid advances in modern gene seeking techniques and the sequence data evolving from related genome research should provide both new targets for drug discovery and new insights into risk factors for many neurological and psychiatric disorders. Couple
Publikováno v:
Molecular Brain Research. 12:233-241
In primary cultures of neurons from cerebral cortex and striatum, 30 s stimulation with the excitatory amino acid gluatamate elicited a 5 to 9-fold increase in immediate early gene (IEG) mRNAs. Glutamate increased c- fos , c- jun , jun -B, and NGFI-A
Autor:
Dorothy W. Gallager, N. Saito, Ronald S. Duman, Kennon M. Garrett, C. Heninger, John F. Tallman, Michael P. Vitek
Publikováno v:
Journal of Molecular Neuroscience. 2:101-107
Rats treated chronically with diazepam develop tolerance to diazepam effects and show changes in sensitivity of GABAergic systems. In order to investigate possible molecular mechanisms associated with these changes, we have evaluated the effects of a
Autor:
John F. Tallman, Dorothy W. Gallager
Publikováno v:
Neurochemical Research. 15:113-118
Molecular biological approaches to the GABAa receptor have resulted in new insights into the structure and pharmacology of this complex. It is known that the GABAa complex is a heterooligomer composed of multiple subunits which contain binding sites
Autor:
John F. Tallman, Geoff White, Matt Crago, Lu Marshall, James V. Cassella, Pamela Albaugh, James Gregory, Dorothy W. Gallagher, Hutchison Alan J, Phil C. Ross
Publikováno v:
Journal of medicinal chemistry. 45(23)
Benzodiazepines are allosteric modulators of the GABA(A) receptor. The traditionally prescribed benzodiazepines are nonselective and suffer from numerous side effects. Upon the identification of receptor subtypes, we set out to discover selective age
Autor:
John F. Tallman
Publisher Summary NGD 94-1 (2-phenyl-4(5)-[4-(2-pyrimidinyl)-piperazin-1-yl)-methyl]-imidazole dimaleate) is a highly selective agent at the D4 receptor—a D4 antagonists. NGD 94-1 possesses a preclinical profile that is at once similar to clozapine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b97b9f571b83afd35a0bc97ea57090f
https://doi.org/10.1016/s1054-3589(08)60795-4
https://doi.org/10.1016/s1054-3589(08)60795-4
Publikováno v:
Journal of receptor research. 14(1)
HeLa cells express low levels of beta-adrenergic receptor (beta AR) of the beta 2-subtype. When exposed to sodium butyrate, receptor levels increased up to 4-fold in a time dependent manner, reaching a maximum after 12 to 15 h of treatment. Sodium bu
Autor:
John F Tallman
Publikováno v:
Neuropsychopharmacology. 23:S1-S2
The articles in this special supplement to Neuropsychopharmacology are collected from research presented at a symposium entitled “Dimerization of G-Protein-Coupled Receptors: Implications for Drug Design and Signaling.” They describe current rese