Zobrazeno 1 - 10
of 90
pro vyhledávání: '"John F. Smiley"'
Autor:
Ying Jiang, John J. Alam, Stephen N. Gomperts, Paul Maruff, Afina W. Lemstra, Ursula A. Germann, Philip H. Stavrides, Sandipkumar Darji, Sandeep Malampati, James Peddy, Cynthia Bleiwas, Monika Pawlik, Anna Pensalfini, Dun-Sheng Yang, Shivakumar Subbanna, Balapal S. Basavarajappa, John F. Smiley, Amanda Gardner, Kelly Blackburn, Hui-May Chu, Niels D. Prins, Charlotte E. Teunissen, John E. Harrison, Philip Scheltens, Ralph A. Nixon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show in an animal model and in a study in patients with dementia with Lewy bodies (DLB) that the drug neflamapimod has potential to treat diseases, such as DLB, associated with loss of neurons that produce the neurotransmitter acetylcholi
Externí odkaz:
https://doaj.org/article/435994d00b734e18a90ea82931cd1bac
Autor:
Mariko Saito, Shivakumar Subbanna, Xiuli Zhang, Stefanie Canals-Baker, John F. Smiley, Donald A. Wilson, Bhaskar C. Das
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Ethanol exposure in neonatal mice induces acute neurodegeneration followed by long-lasting glial activation and GABAergic cell deficits along with behavioral abnormalities, providing a third trimester model of fetal alcohol spectrum disorders (FASD).
Externí odkaz:
https://doaj.org/article/66f6ef13dcbc424e839d900254987a98
Autor:
John F. Smiley, Cynthia Bleiwas, Brandon M. Marino, Prerana Vaddi, Stefanie Canals-Baker, Donald A. Wilson, Mariko Saito
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
In neonatal brain development there is a period of normal apoptotic cell death that regulates adult neuron number. At approximately the same period, ethanol exposure can cause a dramatic spike in apoptotic cell death. While ethanol-induced apoptosis
Externí odkaz:
https://doaj.org/article/29273d561a184576bf39ff159d37efcc
Autor:
Gurjinder Kaur, Sebastien A. Gauthier, Rocio Perez-Gonzalez, Monika Pawlik, Amol Bikram Singh, Benjamin Cosby, Panaiyur S. Mohan, John F. Smiley, Efrat Levy
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 165-173 (2018)
Cystatin C (CysC) plays diverse protective roles under conditions of neuronal challenge. We investigated whether CysC protects from trisomy-induced pathologies in a mouse model of Down syndrome (DS), the most common cause of developmental cognitive a
Externí odkaz:
https://doaj.org/article/3d9f1c007e374667b978464f23656cc0
Autor:
Xiuli Zhang, Shivakumar Subbanna, Colin R. O. Williams, Stefanie Canals-Baker, John F. Smiley, Donald A. Wilson, Bhaskar C. Das, Mariko Saito
Publikováno v:
Neurochemical Research. 48:1958-1970
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe0c11d6b487ba0018fcb747b7fb6c9
https://doi.org/10.1007/s11064-023-03888-x
https://doi.org/10.1007/s11064-023-03888-x
Autor:
Cynthia Bleiwas, Cátia M. Teixeira, Robert M. Sears, Stefanie Canals-Baker, John F. Smiley, Mariko Saito, Donald A. Wilson, Sharifa Z. Williams
Publikováno v:
Alcohol
In animal models that mimic human third-trimester fetal development, ethanol causes substantial cellular apoptosis in the brain, but for most brain structures, the extent of permanent neuron loss that persists into adulthood is unknown. We injected e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe2c454cf988f187e20e10e3fc375d0
https://doi.org/10.1016/j.alcohol.2021.08.005
https://doi.org/10.1016/j.alcohol.2021.08.005
Autor:
Cátia M. Teixeira, Mark S. Ansorge, John F. Smiley, Robert H. Edwards, Edenia C. Menezes, Nao Chuhma, Relish Shah, Cynthia Bleiwas, Francisco X. Castellanos, Stephen Rayport, Catarina Cunha, Rebecca P. Seal
Publikováno v:
Molecular psychiatry
Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or postnatal blockade with selective serotonin reupta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b52d3c8dbb5da59ae3a3950d00019b
https://doi.org/10.1038/s41380-020-0763-z
https://doi.org/10.1038/s41380-020-0763-z
Autor:
Ursula Germann, Cynthia Bleiwas, John Alam, Dun-Sheng Yang, Balapal S. Basavarajappa, Sandeep Malampati, John Harrison, Kelly Blackburn, Afina W. Lemstra, Paul Maruff, Monika Plawik, Shivakumar Subbanna, Amanda Gardner, Niels D. Prins, Charlotte E. Teunissen, Ralph A. Nixon, Ying Jiang, John F. Smiley, Anna Pensalfini, Stephen N. Gomperts, Sandipkumar Darji, Philip Scheltens, James Peddy, Philip Stavrides
The endosome-associated protein Rab5 is a central player in the molecular mechanisms leading to degeneration of basal forebrain cholinergic neurons (BFCN), a long-standing target for drug development. As p38α kinase is a Rab-5 activator, we hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a29c5651356ef59817c7a436ae57df45
https://doi.org/10.21203/rs.3.rs-1061364/v1
https://doi.org/10.21203/rs.3.rs-1061364/v1
Autor:
Judith Betz, Mariko Saito, John F. Smiley, Cynthia Bleiwas, Maria Hui, Eva Petkova, Donald A. Wilson, Kurt Masiello
Publikováno v:
Brain Struct Funct
Neonatal brain lesions cause deficits in structure and function of the cerebral cortex that sometimes are not fully expressed until adolescence. To better understand the onset and persistence of changes caused by postnatal day 7 (P7) ethanol treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3c2ba36c0e0b3feb12e804c9406d93
https://doi.org/10.1007/s00429-019-01881-1
https://doi.org/10.1007/s00429-019-01881-1