Zobrazeno 1 - 10
of 35
pro vyhledávání: '"John F. Sebastian"'
Autor:
Zhiqing Yan, John F. Sebastian
Publikováno v:
Tetrahedron Letters. 45:6551-6555
The NMR characterization of the trienolate product of lithiation of 2,3-dihydrooxepin with 6-lithiodihydropyran in THF is reported. The NMR spectra also support a direct ring opening upon allylic lithiation via an E2-type mechanism rather than vinyli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cbd294bea97cbce48b2661b54c7a496
https://doi.org/10.1016/j.tetlet.2004.07.048
https://doi.org/10.1016/j.tetlet.2004.07.048
Autor:
Zhiqing Yan, John F. Sebastian
Publikováno v:
Tetrahedron Letters. 43:8383-8386
The deprotonation of oxete by ether solvated methyl lithium was investigated by geometry optimization of reactants, transition states and products using the density functional theory (DFT) method (B3LYP/6-31++G(d,p)). The calculations suggest that al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd3c7ae1de28cd7a1f69af9f6d76081d
https://doi.org/10.1016/s0040-4039(02)02015-4
https://doi.org/10.1016/s0040-4039(02)02015-4
Autor:
John F. Sebastian, Trevor D. Power
Publikováno v:
Tetrahedron Letters. 40:6149-6152
Proton affinities of vinyl and allyl anions of cyclic vinyl ethers and cycloalkenes obtained at the B3PW91 level with Davidson's modification of basis set aug-cc-pVDZ are presented to further explore deprotonation reactions of cyclic vinyl ethers. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f838714897107f6829f3ab91ffc956b7
https://doi.org/10.1016/s0040-4039(99)01201-0
https://doi.org/10.1016/s0040-4039(99)01201-0
Autor:
John F. Sebastian, Guiqing Liang
Publikováno v:
Bioorganic Chemistry. 26:295-308
More than fifteen substrates of carboxypeptidase A (CPA) have been “docked” to the active site of the enzyme and searched for the lowest energy conformation of the substrates bound to the active site. The method employed combines Monte Carlo proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a98b465940d43c6ad44b4f363696f85
https://doi.org/10.1006/bioo.1998.1118
https://doi.org/10.1006/bioo.1998.1118
Autor:
Trevor D. Power, John F. Sebastian
Publikováno v:
Tetrahedron. 54:8371-8392
The relative energies of allylic and vinylic anions of several vinyl ethers were determined by ab initio calculations at the Hartree-Fock and second-order Moller-Plesset perturbation theory (single point) levels using basis set 6–31++G(d,p) in an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a034a98ba040fccc924607bf6337a97
https://doi.org/10.1016/s0040-4020(98)00445-1
https://doi.org/10.1016/s0040-4020(98)00445-1
Autor:
John F. Sebastian, Trevor D. Power
Publikováno v:
Tetrahedron Letters. 37:9127-9130
The 2,3-dihydrooxepin ring opens upon deprotonation with strong base presumably through an allylic anion which is predicted to be 15 kcal/mol lower in energy than the vinylic anion. Allylic deprotonation occurs with allyl angle expansion whereas viny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94a634da5c0a994e2fbf50e4dc128d56
https://doi.org/10.1016/s0040-4039(96)02059-x
https://doi.org/10.1016/s0040-4039(96)02059-x
Publikováno v:
Bioorganic Chemistry. 24:290-303
The kinetics of 14 peptide substrates of carboxypeptidase A have been studied for the purpose of evaluating P 1 –P 3 /S 1 –S 3 interactions. It was found that the amide group at P 1 –P 2 is required for efficient catalysis. This observation is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4931f67a1fb46ea9d6a740d1e4021e4
https://doi.org/10.1006/bioo.1996.0026
https://doi.org/10.1006/bioo.1996.0026
Autor:
John F. Sebastian, Trevor D. Power
Publikováno v:
ChemInform. 29
The relative energies of allylic and vinylic anions of several vinyl ethers were determined by ab initio calculations at the Hartree-Fock and second-order Moller-Plesset perturbation theory (single point) levels using basis set 6–31++G(d,p) in an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1814783683052c0f3483c8c9b2911c28
https://doi.org/10.1002/chin.199843023
https://doi.org/10.1002/chin.199843023
Autor:
Jeffrey L. Frye, John F. Sebastian
Publikováno v:
Biochemistry and Cell Biology. 68:1062-1065
The effects of sulfonates on the carboxypeptidase A catalyzed hydrolysis of the ester substrate benzoylglycyl-L-phenyllactate were determined. The modifiers examined were benzenesulfonate, p-toluenesulfonate, 2-phenylethanesulfonate, methanesulfonate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df240a81e6367544ae95197313d7995
https://doi.org/10.1139/o90-157
https://doi.org/10.1139/o90-157