Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John F. Saville"'
Antihypertensive thiadiazoles. 2. Vasodilator activity of some 2-aryl-5-guanidino-1,3,4-thiadiazoles
Autor:
Brian Gadie, Anthony J. Nelson, Stephen Turner, Robin Pape, Malcolm Myers, Stafford A. Hale, John F. Saville, John C. Doxey, Timothy L. Berridge, Alan Horsley
Publikováno v:
Journal of Medicinal Chemistry. 31:906-913
Some 2-aryl-5-guanidino-(or N-substituted guanidino)-1,3,4-thiadiazoles and closely related analogues were found to lower blood pressure in metacorticoid (DOCA) hypertensive rats. In the unsubstituted guanidines that exhibited low toxicity, optimum a
Autor:
Malcolm Myers, Peter Myers, John F. Saville, Donald S. Walter, Christopher B. Chapleo, Michael R. Stillings, Ian F. Tulloch, Alan C. B. Smith, Anthony P. Welbourn
Publikováno v:
Journal of medicinal chemistry. 29(11)
The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number
Autor:
Brian Gadie, Malcolm Myers, Robin Pape, Stephen Turner, John F. Saville, Timothy L. Berridge, Anthony J. Nelson, John C. Doxey
Publikováno v:
Journal of medicinal chemistry. 31(5)
Some 2-aryl-5-hydrazino-1,3,4-thiadiazoles have been synthesized and screened for antihypertensive activity. In general, compounds with a 2-substituted phenyl ring had higher activity than their 3- or 4-substituted counterparts or those containing he
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :231
Oxidation of an aromatic methyl group para to a methoxy-substituent in some 4-arylpiperidines has been observed using Jones' reagent at 5–20 °C; the mechanism of this result is discussed.