Zobrazeno 1 - 10
of 40
pro vyhledávání: '"John F. Reed"'
Autor:
Ewa Galaj, Guo-Hua Bi, Benjamin Klein, Briana Hempel, Anver Basha Shaik, Emma S. Gogarnoiu, Jacob Friedman, Jenny Lam, Rana Rais, John F. Reed, Shelley H. Bloom, Tracy L. Swanson, Jennifer L. Schmachtenberg, Amy J. Eshleman, Aaron Janowsky, Zheng-Xiong Xi, Amy Hauck Newman
Publikováno v:
Neuropsychopharmacology. 47:2309-2318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d8581437ec2390de249cb8d99bc1090
https://doi.org/10.1038/s41386-022-01379-1
https://doi.org/10.1038/s41386-022-01379-1
Autor:
Jennifer L. Schmachtenberg, John F. Reed, Randy Torralva, Tracy L. Swanson, William E. Schutzer, Katherine M. Wolfrum, Amy J. Eshleman, Shelley H. Bloom, Aaron Janowsky
Publikováno v:
J Pharmacol Exp Ther
Synthetic opioids, including fentanyl and its analogs, have therapeutic efficacy in analgesia and anesthesia. However, their illicit use in the United States has increased and contributed to the number one cause of death for adults 18–50 years old.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20e92ee3ca2ff2d4f14709bce93e7be2
https://doi.org/10.1124/jpet.120.265561
https://doi.org/10.1124/jpet.120.265561
Autor:
Ewa, Galaj, Guo-Hua, Bi, Benjamin, Klein, Briana, Hempel, Anver Basha, Shaik, Emma S, Gogarnoiu, Jacob, Friedman, Jenny, Lam, Rana, Rais, John F, Reed, Shelley H, Bloom, Tracy L, Swanson, Jennifer L, Schmachtenberg, Amy J, Eshleman, Aaron, Janowsky, Zheng-Xiong, Xi, Amy Hauck, Newman
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(13)
The non-medical use of opioids has become a national crisis in the USA. Developing non-opioid pharmacotherapies for controlling this opioid epidemic is urgent. Dopamine D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f2d1b8117627a0d92163cd64304df59
https://pubmed.ncbi.nlm.nih.gov/35879349
https://pubmed.ncbi.nlm.nih.gov/35879349
Autor:
John F. Reed, Aaron Janowsky, Robert A. Johnson, Katherine M. Wolfrum, Sunyoung O. Kim, Amy J. Eshleman
Publikováno v:
Biochemical Pharmacology. 158:27-34
The use of new psychoactive substituted 2,5-dimethoxy-N-benzylphenethylamines is associated with abuse and toxicity in the United States and elsewhere and their pharmacology is not well known. This study compares the mechanisms of action of 2(2,5-dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83dc5f4d95c9786704f7dbab90fd0a78
https://doi.org/10.1016/j.bcp.2018.09.024
https://doi.org/10.1016/j.bcp.2018.09.024
Autor:
Tracy L. Swanson, Sunyoung O. Kim, Katherine M. Wolfrum, Aaron Janowsky, Amy J. Eshleman, John F. Reed, Robert A. Johnson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 360:33-47
Synthetic cathinones are components of “bath salts” and have physical and psychologic side effects, including hypertension, paranoia, and hallucinations. Here, we report interactions of 20 “bath salt” components with human dopamine, serotonin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9862eba441a6a5de5da06ca382b89b3e
https://doi.org/10.1124/jpet.116.236349
https://doi.org/10.1124/jpet.116.236349
Autor:
Aaron Janowsky, Aaron Nilsen, John F. Reed, Katherine M. Wolfrum, Shanthi Nagarajan, Amy J. Eshleman, Randy Torralva
Publikováno v:
Biochemical Pharmacology. 182:114293
Substituted fentanyls are abused and cause rapid fatal overdose. As their pharmacology is not well characterized, we examined in vitro pharmacology and structure-activity relationships of 22 substituted fentanyls with modifications of the fentanyl pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5d7d43c6467359a2d142396d884a0b
https://doi.org/10.1016/j.bcp.2020.114293
https://doi.org/10.1016/j.bcp.2020.114293
Autor:
Tracy L. Swanson, Shanthi Nagarajan, Katherine M. Wolfrum, John F. Reed, Aaron Nilsen, Aaron Janowsky, Amy J. Eshleman
Publikováno v:
Psychopharmacology. 236(3)
New psychoactive substances (NPSs), including substituted cathinones and other stimulants, are synthesized, sold on the Internet, and ingested without knowledge of their pharmacological activity and/or toxicity. In vitro pharmacology plays a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8797c6db87886995499eb7fc37e7ecf
https://pubmed.ncbi.nlm.nih.gov/30397775
https://pubmed.ncbi.nlm.nih.gov/30397775
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 61:899-906
Beta-adrenergic receptor (beta-AR)-mediated vasorelaxation declines with age. In the vasculature, beta2-AR undergoes protein kinase A-mediated desensitization that causes a switch in the G protein coupled to beta2-AR; Galphai links instead of Galphas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f77dc113de139dd149ef4cdd00ba543c
https://doi.org/10.1093/gerona/61.9.899
https://doi.org/10.1093/gerona/61.9.899
Autor:
Sharon Anderson, Radko Komers, Terry T. Oyama, William E. Schutzer, Scott L. Mader, John F. Reed, Jessie N. Lindsley, David C. Buck
Publikováno v:
Diabetes. 55:1651-1659
Experimental diabetes is associated with complex changes in renal nitric oxide (NO) bioavailability. We explored the effect of diabetes on renal cortical protein expression of endothelial NO synthase (eNOS) with respect to several determinants of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9abd4a065271417aadd142e7a0e03b
https://doi.org/10.2337/db05-1595
https://doi.org/10.2337/db05-1595
Autor:
Radko Komers, William E. Schutzer, Sharon Anderson, John F. Reed, Scott L. Mader, Terry T. Oyama, Jessie N. Lindsley
Publikováno v:
Journal of Clinical Investigation. 107:889-898
Prostaglandins (PGs) generated by the enzyme cyclooxygenase (COX) have been implicated in the pathological renal hemodynamics and structural alterations in diabetes mellitus, but the role of individual COX isoenzymes in diabetic nephropathy remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639b266a3a60e91d8ba2af26d335f16f
https://doi.org/10.1172/jci10228
https://doi.org/10.1172/jci10228