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pro vyhledávání: '"John F. Patzer"'
Autor:
II John F. Patzer
Publikováno v:
Artificial Organs. 32:499-508
New detoxification modes of treatment for liver failure that use solid adsorbents to remove toxins bound to albumin in the patient bloodstream are entering clinical evaluations, frequently in head-to-head competition. While generally effective in red
Publikováno v:
Liver Transplantation. 14:1048-1057
Elevated intracranial pressure (ICP) leads to loss of cerebral perfusion, cerebral herniation, and irreversible brain damage in patients with acute liver failure (ALF). Conventional techniques for monitoring ICP can be complicated by hemorrhage and i
Publikováno v:
Regenerative Medicine. 3:575-595
Acute liver disease is a life-threatening condition for which liver transplantation is the only recognized effective therapy. While etiology varies considerably, the clinical course of acute liver failure is common among the etiologies: encephalopath
Publikováno v:
Artificial Organs. 31:834-839
Life-threatening, severely elevated intracranial pressure (ICP) is a common feature of acute liver failure (ALF). Perfusion with a bioartificial liver may serve to mitigate rising ICP. A retrospective analysis of ICP measurements in a canine ALF mode
Autor:
John F. Patzer
Publikováno v:
Therapeutic Apheresis and Dialysis. 10:118-124
Toxins that bind to albumin in the bloodstream and are associated with progressing liver failure have proven refractory to removal by conventional hemodialysis. Such toxins can, however, be removed by adding a binder to the dialysate that serves to c
Autor:
John F. Patzer
Publikováno v:
Annals of the New York Academy of Sciences. 944:320-333
Rapid advances in development of bioartificial liver assist devices (BLADs) are exciting clinical interest in the application of BLAD technology for support of patients with acute liver failure. Four devices (Circe Biomedical HepatAssist, Vitagen ELA
Publikováno v:
ASAIO Journal. 52:47-58
Bound solute dialysis (BSD), often referred to as "albumin dialysis" (practiced clinically as the molecular adsorbents recirculating system, MARS, or single-pass albumin dialysis, SPAD) or "sorbent dialysis" (practiced clinically as the charcoal-base
Autor:
T A Grogan, M L Fulmer, George V. Mazariegos, Michael E. DeVera, John F. Patzer, Mauricio Giraldo, B P Amiot, David J. Kramer, Roberto Lopez, Yue Zhu
Publikováno v:
American Journal of Transplantation. 2:260-266
The first clinical use of the Excorp Medical Bioartificial Liver Support System (BLSS) in support of a 41-year-old African-American female with fulminant hepatic failure is described. The BLSS is currently in a Phase I/II safety evaluation at the Uni
Autor:
Abdul S. Rao, David J. Kramer, Roberto Lopez, George V. Mazariegos, R Kuddus, John F. Patzer, B. Meighen
Publikováno v:
Transplantation. 73:420-429
Background. The potential risk of transmission of porcine endogenous retroviruses (PERV) from xenogeneic donors into humans has been widely debated. Because we were involved in a phase I/II clinical trial using a bioartificial liver support system (B
Autor:
A J Rosenbloom, George V. Mazariegos, Y Zhu, M L Fulmer, John F. Patzer, Michael E. DeVera, B P Amiot, M Giraldo, A O Shakil, David J. Kramer, Roberto Lopez, T A Grogan
Publikováno v:
ASAIO Journal. 47:471-475
A Phase I clinical safety evaluation of the Excorp Medical, Inc, Bioartificial Liver Support System (BLSS) is in progress. Inclusion criteria are patients with acute liver failure of any etiology, presenting with encephalopathy deteriorating beyond P