Zobrazeno 1 - 10
of 121
pro vyhledávání: '"John F. Neumaier"'
A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal
Autor:
Kevin R. Coffey, Atom J. Lesiak, Russell G. Marx, Emily K. Vo, Gwenn A. Garden, John F. Neumaier
Publikováno v:
Biological Psychiatry Global Open Science, Vol 2, Iss 2, Pp 180-189 (2022)
Background: Microglia have recently been implicated in opioid dependence and withdrawal. Mu opioid receptors are expressed in microglia, and microglia form intimate connections with nearby neurons. Accordingly, opioids have both direct (mu opioid rec
Externí odkaz:
https://doaj.org/article/1af6c1ee1f5447cab3c93906a506998a
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100268- (2020)
The lateral habenula (LHb) integrates critical information regarding aversive stimuli that shapes decision making and behavioral responses. The three major LHb outputs innervate dorsal raphe nucleus (DRN), ventral tegmental area (VTA), and the rostro
Externí odkaz:
https://doaj.org/article/f3a8de9ef1304d5083824b089e1e3a85
Publikováno v:
BioTechniques, Vol 58, Iss 6, Pp 308-317 (2015)
Primary neuronal cultures are a useful tool for measuring pharmacological- and transgene-regulated gene expression; however, accurate measurements can be confounded by heterogeneous cell types and inconsistent transfection efficiency. Here we describ
Externí odkaz:
https://doaj.org/article/391af7ec5e1543959e0c684893b264e2
Publikováno v:
bioRxiv
Opioid use disorder has become an epidemic in the United States, fueled by the widespread availability of fentanyl, which produces rapid and intense euphoria followed by severe withdrawal and emotional distress. We developed a new preclinical model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1baf0ebad67094c2dbb28b87865a5ba1
https://europepmc.org/articles/PMC10168304/
https://europepmc.org/articles/PMC10168304/
Autor:
Rachelle Tran, Antony D. Abraham, Benjamin B. Land, Phillip R. Silva, Harrison M. Fontaine, John F. Neumaier, Carlie Neiswanger, Charles Chavkin
Publikováno v:
Neuropsychopharmacology. 47:891-901
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. In male mice, we fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bc2eb371987f642bd379c4d32e63266
https://doi.org/10.1038/s41386-021-01178-0
https://doi.org/10.1038/s41386-021-01178-0
A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal
Autor:
Russell G. Marx, Gwenn A. Garden, Kevin R. Coffey, Atom J. Lesiak, John F. Neumaier, Emily K. Vo
Publikováno v:
Biol Psychiatry Glob Open Sci
Background Microglia have recently been implicated in opioid dependence and withdrawal. Mu Opioid (MOR) receptors are expressed in microglia, and microglia form intimate connections with nearby neurons. Accordingly, opioids have both direct (MOR medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09b7c72ed0e1e84d1e465395e308a61
https://pubmed.ncbi.nlm.nih.gov/35441155
https://pubmed.ncbi.nlm.nih.gov/35441155
Autor:
Marjorie R. Levinstein, David J. Bergkamp, Zoë K. Lewis, Alex Tsobanoudis, Koichi Hashikawa, Garret D. Stuber, John F. Neumaier
Publikováno v:
Genes Brain Behav
The lateral habenula (LHb) is a small, bilateral, epithalamic nucleus which processes aversive information. While primarily glutamatergic, LHb neurons express genes coding for many neuropeptides, such as Adcyap1 the gene encoding pituitary adenylate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac1600f8d73c4bcae8bc04865e3f530
https://europepmc.org/articles/PMC9444940/
https://europepmc.org/articles/PMC9444940/
Autor:
Katharine J. Liang, Charles Chavkin, Kevin R. Coffey, John F. Neumaier, Joshua H Cohen, Atom J. Lesiak
Publikováno v:
Molecular psychiatry
Serotonin is a key mediator of stress, anxiety, and depression, and novel therapeutic targets within serotonin neurons are needed to combat these disorders. To determine how stress alters the translational profile of serotonin neurons, we sequenced r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5528f46f2bce23284795fb0457d27506
https://doi.org/10.1038/s41380-020-0750-4
https://doi.org/10.1038/s41380-020-0750-4
Autor:
Benjamin B. Land, Rachelle Tran, Phillip R. Silva, Antony D. Abraham, Charles Chavkin, Carlie Neiswanger, Harrison M. Fontaine, John F. Neumaier
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in monoaminergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. We found that condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b3335943291ba42d631e06a5bac34f
https://doi.org/10.1101/2021.06.27.450100
https://doi.org/10.1101/2021.06.27.450100
Autor:
Dennis J. Sholler, Kathryn A. Cunningham, F. Gerard Moeller, Noelle C. Anastasio, John F. Neumaier, Amanda E. Price, Jonathan D. Hommel, Sonja J. Stutz, Brionna D. Davis-Reyes, Susan M. Ferguson
Publikováno v:
Neuropsychopharmacology
Food intake is essential for survival, but maladaptive patterns of intake, possibly encoded by a preexisting vulnerability coupled with the influence of environmental variables, can modify the reward value of food. Impulsivity, a predisposition towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd835f3539b8ebbdcd5aafe67affd71
https://doi.org/10.1038/s41386-019-0394-8
https://doi.org/10.1038/s41386-019-0394-8