Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John F. MacMaster"'
Autor:
Kurt R. Gregor, Kim W. McIntyre, Carl Ouellet, Francis Beaulieu, Ruediger Edward H, Xuejie Yang, Yuping Qiu, Alain Martel, Dolatrai M. Vyas, Jacques Banville, F. Christopher Zusi, James R. Burke, Makonen Belema, John F. MacMaster, Mark A. Pattoli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:1233-1237
We have recently identified BMS-345541 (1) as a highly selective and potent inhibitor of IKK-2 (IC50 = 0.30 μM), which however was considerably less potent against IKK-1 (IC50 = 4.0 μM). In order to further explore the SAR around the imidazoquinoxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db465e3a81193049682a395e7cdc426
https://doi.org/10.1016/j.bmcl.2006.12.017
https://doi.org/10.1016/j.bmcl.2006.12.017
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3591-3594
A series of unsymmetrical polar disulfide prodrugs 2-5 of paclitaxel were designed and synthesized as reductively activated prodrugs. These compounds behaved as prodrugs in vitro on L2987 lung carcinoma cells. In vivo evaluation in mice demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ce6768c471d37acd8e877ce05ea9c0
https://doi.org/10.1016/s0960-894x(02)00784-9
https://doi.org/10.1016/s0960-894x(02)00784-9
Autor:
T G Murali, Dhar, Zhongqi, Shen, Junqing, Guo, Chunjian, Liu, Scott H, Watterson, Henry H, Gu, William J, Pitts, Catherine A, Fleener, Katherine A, Rouleau, N Z, Sherbina, Kim W, McIntyre, David J, Shuster, Mark R, Witmer, Jeffrey A, Tredup, Bang-Chi, Chen, Rulin, Zhao, Mark S, Bednarz, Daniel L, Cheney, John F, MacMaster, Laura M, Miller, Karen K, Berry, Timothy W, Harper, Joel C, Barrish, Diane L, Hollenbaugh, Edwin J, Iwanowicz
Publikováno v:
Journal of Medicinal Chemistry. 45:2127-2130
Inosine monophosphate dehydrogenase (IMPDH) is a key enzyme that is involved in the de novo synthesis of purine nucleotides. Novel 2-aminooxazoles were synthesized and tested for inhibition of IMPDH catalytic activity. Multiple analogues based on thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca2aa677fef1988fcc5ec2d51e58256
https://doi.org/10.1021/jm0105777
https://doi.org/10.1021/jm0105777
Autor:
Philip M. Wallace, John F. MacMaster, Katherine A. Rouleau, T. Joseph Brown, James K. Loy, Karen L. Donaldson, Alan F. Wahl
Publikováno v:
The Journal of Immunology. 162:5547-5555
Oncostatin M (OM) is a pleiotropic cytokine produced late in the activation cycle of T cells and macrophages. In vitro it shares properties with related proteins of the IL-6 family of cytokines; however, its in vivo properties and physiological funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73dcb1d36adf8f331b20e5ab7a9fa889
https://doi.org/10.4049/jimmunol.162.9.5547
https://doi.org/10.4049/jimmunol.162.9.5547
Autor:
Philip M. Wallace, Jill Rillema, Jingpeng Peng, Samuel A. Burstein, Mohammed Shoyab, John F. MacMaster
Publikováno v:
Blood. 86:1310-1315
Oncostatin M (OM) is a 28-kD glycoprotein that exhibits a panoply of biologic effects. Based on histologic observations of increased splenic megakaryocytes in nude mice implanted with an OM-secreting cell line, the thrombocytopoietic properties of OM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9de95c50075ea28ae5f57cefeac8d341
https://doi.org/10.1182/blood.v86.4.1310.bloodjournal8641310
https://doi.org/10.1182/blood.v86.4.1310.bloodjournal8641310
Autor:
Paul Gladstone, Jennifer S. Johnson, John F. MacMaster, Karen A. Kennedy, Peter S. Linsley, Philip M. Wallace
Publikováno v:
Transplantation. 58:602-610
Graft-versus-host disease (GVHD), a pathological condition associated with BMT, results from activation of donor T lymphocytes by host tissues. CD28 and CTLA-4 are structurally related T cell receptors for members of the B7 (CD80) gene family, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6eea3a00abc45aa8f25c1fb6163192
https://doi.org/10.1097/00007890-199409150-00013
https://doi.org/10.1097/00007890-199409150-00013
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 315(1)
It has previously been shown that BMS-345541 [4(2'-aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline], a highly-selective inhibitor of IkappaB kinase (IKK), blocks both inflammation and joint destruction in murine collagen-induced arthritis. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b11a2bc5ba15091c0f011454cc9dd0
https://pubmed.ncbi.nlm.nih.gov/16009742
https://pubmed.ncbi.nlm.nih.gov/16009742
Autor:
Fred Christopher Zusi, Donna M. Dambach, James R. Burke, Yuping Qiu, K. K. Berry, D. B. Lee, John F. MacMaster
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 52(12)
Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are characterized by chronic relapsing inflammation. The transcription of many of the proteins which mediate the pathogenesis in inflammatory bowel disease (e.g., TNFalpha, IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26787df1e0dd9216985ac1030dbb792
https://pubmed.ncbi.nlm.nih.gov/14991079
https://pubmed.ncbi.nlm.nih.gov/14991079
Autor:
Kim W. McIntyre, Mark A. Pattoli, James R. Burke, Violetta Iotzova, Joann Strnad, Qiu Yuping, Patrick J. Brassil, Kurt R. Gregor, F. Christopher Zusi, Wendy Clarke, Xiaoxia Yang, John F. MacMaster
Publikováno v:
The Journal of biological chemistry. 278(3)
The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent ubiquitination and proteolysis of I kappa B alpha, which then releases NF-kappa B to promote gene transcription. The multisubunit I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f62b87cf59cb6cd6bac92c557bca08
https://pubmed.ncbi.nlm.nih.gov/12403772
https://pubmed.ncbi.nlm.nih.gov/12403772
Autor:
Karen K. Berry, Davidson Thomas J, John F. MacMaster, Bharat Danle, James Loy, Stephen K. Durham
Publikováno v:
Toxicologic pathology. 27(2)
Oncostatin M (OM) is a member of the interleukin-6 (IL-6) cytokine subfamily. The binding of OM to its receptor initiates signal transduction through JAK-signal transducers and activators of transcription (STAT) pathways and activates transcription a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19064cc5e90fe7668f9ec6508ba885ed
https://pubmed.ncbi.nlm.nih.gov/10207978
https://pubmed.ncbi.nlm.nih.gov/10207978