Zobrazeno 1 - 10
of 201
pro vyhledávání: '"John F. MacDonald"'
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 2, Pp 3003-3024 (2014)
G Protein Coupled Receptors (GPCRs) are the largest family of receptors whose ligands constitute nearly a third of prescription drugs in the market. They are widely involved in diverse physiological functions including learning and memory. NMDA recep
Externí odkaz:
https://doaj.org/article/05c567833ba147b4a257b180aa81ec58
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21970 (2011)
Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://doaj.org/article/0092b488c74a4da3af27c8d2703eb7ec
Publikováno v:
Hippocampus. 24:1601-1614
Endocannabinoids (eCBs), including AEA and 2-AG, are endogenous signaling mediators involved in many physiological and pathological events. The G protein-coupled cannabinoid receptor 1 (CB1R) is an important target for eCBs, however, additional non-C
Publikováno v:
Scientific Reports
N-methyl-D-aspartate receptors (NMDARs) are necessary for the induction of synaptic plasticity and for the consolidation of learning and memory. NMDAR function is tightly regulated by functionally opposed families of kinases and phosphatases. Herein
Autor:
Glaucia N. M. Hajj, John F. MacDonald, Ana Cathia Magalhães, Wing-Yiu Choy, Guillaume Lamour, Vilma R. Martins, Amro H. Mohammad, Pedro H. F. Hirata, Neil R. Cashman, Vania F. Prado, Valeriy G. Ostapchenko, Michael F. Jackson, Andrzej Maciejewski, Flavio H. Beraldo, Margaret Fahnestock, Sergio T. Ferreira, Hongbin Li, Yu-Feng Xie, Jillian C. Belrose, Marco A. M. Prado, Bianca Luise Teixeira
Publikováno v:
Anatomy and Cell Biology Publications
In Alzheimer's disease (AD), soluble amyloid-β oligomers (AβOs) trigger neurotoxic signaling, at least partially, via the cellular prion protein (PrPC). However, it is unknown whether other ligands of PrPCcan regulate this potentially toxic interac
Autor:
Daniela F. Goncalves, Rohit Kesarwani, John F. MacDonald, Marco A. M. Prado, Michael F. Jackson, Xavier De Jaeger, Sanda Raulic, Amanda C. Martyn, Ivan Izquierdo, Vania F. Prado, Ana C. Magalhães, Monica S. Guzman
Publikováno v:
Anatomy and Cell Biology Publications
Basal forebrain cholinergic neurons, which innervate the hippocampus and cortex, have been implicated in many forms of cognitive function. Immunolesion-based methods in animal models have been widely used to study the role of acetylcholine (ACh) neur
Autor:
Flavio H. Beraldo, Michael F. Jackson, Marco A. M. Prado, John F. MacDonald, Jue Fan, Jillian C. Belrose, Monica S. Guzman, Valeriy G. Ostapchenko, Vania F. Prado, Yasuo Mori, Amanda C. Martyn, Natalie Lavine, Megan Chen, Yu-Feng Xie
Publikováno v:
Anatomy and Cell Biology Publications
In Alzheimer's disease, accumulation of soluble oligomers of β-amyloid peptide is known to be highly toxic, causing disturbances in synaptic activity and neuronal death. Multiple studies relate these effects to increased oxidative stress and aberran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0d1d0893f2f6e438318d10d3ec5092
https://ir.lib.uwo.ca/context/anatomypub/article/1082/viewcontent/15157.full.pdf
https://ir.lib.uwo.ca/context/anatomypub/article/1082/viewcontent/15157.full.pdf
Autor:
Beverley A. Orser, Michael F. Jackson, Kai Yang, Catherine H. Trepanier, Gang Lei, Yu-Feng Xie, John F. MacDonald, Tadashi Yamamoto, Takanobu Nakazawa, Michael W. Salter, Hongbin Li, Bikram Sidhu
Publikováno v:
The EMBO Journal. 31:805-816
Metaplasticity is a higher form of synaptic plasticity that is essential for learning and memory, but its molecular mechanisms remain poorly understood. Here, we report that metaplasticity of transmission at CA1 synapses in the hippocampus is mediate
Publikováno v:
FEBS Journal. 279:12-19
The phosphorylation and trafficking of N-methyl-d-aspartate (NMDA) receptors are tightly regulated by the Src family tyrosine kinase Fyn, through dynamic interactions with various scaffolding proteins in the NMDA receptor complex. Fyn acts as a point
Publikováno v:
Journal of Molecular Neuroscience. 42:319-326
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two closely related peptides, which can activate protein kinase A (PKA). At least three receptors for PACAP and VIP have been identified. The PACAP