Zobrazeno 1 - 10
of 43
pro vyhledávání: '"John F. Lyons"'
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary tables 1-6 summarise the kinase panel screen data (1) mouse PK parameters (2) and further details of the anti-tumour activity (5) conferred by ASTX029, plus details of cell lines used in this study (3 and 4) and further details of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1
https://doi.org/10.1158/1535-7163.22521489.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
XIAP antagonism measurements in HEK293-XIAP-Caspase-9 xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cea30a6b0c9a71da2f81b77d7c229ca
https://doi.org/10.1158/1535-7163.22505335
https://doi.org/10.1158/1535-7163.22505335
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
XIAP antagonism in A375 cells in the presence or absence of TNF-α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272a919c682891395a5262d9906acd9f
https://doi.org/10.1158/1535-7163.22505338
https://doi.org/10.1158/1535-7163.22505338
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Preparation of 2-chloro-1-{6-[(4-fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1H,2H,3H-pyrrolo[3,2-b]pyridin-1-yl}ethan-1-one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2eeafc320764ac1f08c123c93107d2
https://doi.org/10.1158/1535-7163.22505329.v1
https://doi.org/10.1158/1535-7163.22505329.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Fold induction in secreted cytokine concentrations in PBMC supernatants after IAP antagonist treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e98517451841d4234f3bcbe24f80914
https://doi.org/10.1158/1535-7163.22505323.v1
https://doi.org/10.1158/1535-7163.22505323.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary figures 1-7 show the effects of AST029 on ERK signalling in RAS-mutant cell lines (1) and tumour xenograft tissue (3), ASTX029 plasma PK linearity (2), ASTX029 activity in a cell line panel showing MAPK mutation status (4) the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1
https://doi.org/10.1158/1535-7163.22521498.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Because of their roles in the evasion of apoptosis, inhibitor of apoptosis proteins (IAP) are considered attractive targets for anticancer therapy. Antagonists of these proteins have the potential to switch prosurvival signaling pathways in cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60ea6ce021ef990a70160ade83095bf
https://doi.org/10.1158/1535-7163.c.6538027.v1
https://doi.org/10.1158/1535-7163.c.6538027.v1
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Comparison of XIAP activity, cIAP1 activity and selectivity of clinical IAP antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85da46fc2c75c675307fd7bf03528177
https://doi.org/10.1158/1535-7163.22505326
https://doi.org/10.1158/1535-7163.22505326
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
IncuCyte images from neutralization of TNF-α activity with anti-TNF-α experiment in MDA-MB-231 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4c0f6b75cc6fa19875286c5f782761
https://doi.org/10.1158/1535-7163.22505344
https://doi.org/10.1158/1535-7163.22505344
Autor:
Gianni Chessari, Nicola G. Wallis, Nicola E. Wilsher, Pamela A. Williams, Neil T. Thompson, Tomoko Smyth, Sharna J. Rich, Joanne M. Munck, Vanessa Martins, John F. Lyons, Christopher N. Johnson, Jong Sook Ahn, Edward J. Lewis, George A. Ward
Additional data from ASTX669 in vivo xenograft studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b061558ab6ef8c449e79846c4d1c9e38
https://doi.org/10.1158/1535-7163.22505332
https://doi.org/10.1158/1535-7163.22505332