Zobrazeno 1 - 10
of 39
pro vyhledávání: '"John F. Kozlowski"'
Publikováno v:
Biochemistry. 37:854-866
Certain plant species belonging to the family Annonaceae produce Annonaceous acetogenins, which are a unique class of long-chain fatty acid derivatives with potent cytotoxicity. Putative protein targets of the acetogenins are membrane-associated prot
Autor:
Ankush B. Argade, Mark Cushman, John F. Kozlowski, and Phillip E. Fanwick, Rajesh Devraj, Rudiger D. Haugwitz
Publikováno v:
The Journal of Organic Chemistry. 63:273-278
The Michael addition of thiols to brefeldin A occurs with high diastereoselectivity, affording ratios of major to minor diastereomers of at least 30:1. On the basis of the X-ray structure of a crystalline dibenzoyl derivative, the major diastereomers
Autor:
Hiroko Shimada, Lingling L. Rogers, Feras Q. Alali, Lu Zeng, John F. Kozlowski, Jerry L. McLaughlin, Holly A. Johnson
Publikováno v:
Journal of Natural Products. 61:64-70
Bioactivity-directed fractionation of the root bark of Melia volkensii resulted in the isolation of two new natural products, meliavolkinin (1) and melianin C (3), together with two known compounds, 1,3-diacetylvilasinin (2) and melianin B (4). Jones
Publikováno v:
Journal of Natural Products. 60:581-586
The bark of Annona squamosa yielded three new mono-tetrahydrofuran (THF) ring acetogenins, each bearing two flanking hydroxyls and a carbonyl group at the C-9 position. These compounds were isolated using the brine shrimp lethality assay as a guide f
Autor:
Lu Zeng, Karl V. Wood, John F. Kozlowski, Jin-Feng Chao, Zhe-Ming Gu, Geng-Xian Zhao, Jerry L. McLaughlin
Publikováno v:
Tetrahedron. 51:7149-7160
Trilobacin ( 1 ) is the only previously reported Annonaceous acetogenin with the erythro relative configuration between the adjacent bis-tetrahydrofuran (THF) rings. The relative configuration in the adjacent bis-THF moiety of 1 was corrected to thre
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:473-478
A mixture of two novel cytotoxic adjacent bis-tetrahydrofuran (THF) ketolactone acetogenins, (2,4- cis and trans )-bulladecinones ( 1 and 2 ), was isolated from the bark of Annona bullata Rich. (Annonaceae). Adjacent bis-THF rings, located at C-12 an
Publikováno v:
Journal of the American Chemical Society. 115:1088-1094
Nitrogen-15 nuclear magnetic resonance spectroscopy was used to determine the structure of the active-site histidine-70 adduct formed when β-hydroxydecanoyl thiol ester dehydrase from Escherchia coli reacts with the mechanism-based inactivator S-(3-
Autor:
Jerry L. McLaughlin, J. K. Rupprecht, J. M. Saad, Geng-Xian Zhao, Jon E. Anderson, Karl V. Wood, John F. Kozlowski, Yu-Hua Hui
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
Autor:
Matthew J. Rieser, P. R. Hanson, John F. Kozlowski, T. R. Hoye, Jerry L. McLaughlin, Yu-Hua Hui, Karl V. Wood, Z. Zhuang, J. K. Rupprecht
Publikováno v:
ChemInform. 24