Zobrazeno 1 - 10
of 90
pro vyhledávání: '"John F. Kerrigan"'
Autor:
Timothy E. Green, Mark F. Bennett, Ilka Immisch, Jeremy L. Freeman, Karl Martin Klein, John F. Kerrigan, Lata Vadlamudi, Erin L. Heinzen, Ingrid E. Scheffer, A. Simon Harvey, Felix Rosenow, Michael S. Hildebrand, Samuel F. Berkovic
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100810- (2023)
Purpose: Hypothalamic hamartoma (HH) can be syndromic (eg, Pallister-Hall syndrome [PHS], HH, and mesoaxial polydactyly) or nonsyndromic. Most PHS cases have germline variants in GLI3, but a minority remain unresolved. Some nonsyndromic HH cases have
Externí odkaz:
https://doaj.org/article/939d0ee271c64f53839c1bf55c7c6650
Autor:
Jie Wu, Ming Gao, Stephen G. Rice, Candy Tsang, John Beggs, Dharshaun Turner, Guohui Li, Bo Yang, Kunkun Xia, Fenfei Gao, Shenfeng Qiu, Qiang Liu, John F. Kerrigan
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 96-102 (2016)
Human hypothalamic hamartoma (HH) is a rare subcortical lesion associated with treatment-resistant epilepsy. Cellular mechanisms responsible for epileptogenesis are unknown. We hypothesized that neuronal gap junctions contribute to epileptogenesis th
Externí odkaz:
https://doaj.org/article/0df11f70db38449cb37d5eca4c9f2c85
Publikováno v:
Frontiers in Neurology, Vol 4 (2013)
Objective: Human hypothalamic hamartomas (HH) are intrinsically epileptogenic and are associated with treatment-resistant gelastic seizures. The basic cellular mechanisms responsible for seizure onset within HH are unknown. We used intra-operative mi
Externí odkaz:
https://doaj.org/article/de97b14a4d2e49ad8425ebd071879672
Autor:
Timothy E Green, Joshua E Motelow, Mark F Bennett, Zimeng Ye, Caitlin A Bennett, Nicole G Griffin, John A Damiano, Richard J Leventer, Jeremy L Freeman, A Simon Harvey, Paul J Lockhart, Lynette G Sadleir, Amber Boys, Ingrid E Scheffer, Heather Major, Benjamin W Darbro, Melanie Bahlo, David B Goldstein, John F Kerrigan, Erin L Heinzen, Samuel F Berkovic, Michael S Hildebrand
Publikováno v:
Hum Mol Genet
Hypothalamic hamartoma with gelastic seizures is a well-established cause of drug-resistant epilepsy in early life. The development of novel surgical techniques has permitted the genomic interrogation of hypothalamic hamartoma tissue. This has reveal
Autor:
Samuel F. Berkovic, John F. Kerrigan, Dale K. Hesdorffer, Clifford B. Saper, Alexis Arzimanoglou, Andreas Schulze-Bonhage, William D. Gaillard, Lisa Soeby, Nathan T. Cohen, Ilene Miller, Erica Webster, J. Helen Cross, Barbara Kroner, Arthur Cukiert
Publikováno v:
Neurology. 97:864-873
Hypothalamic hamartomas (HH) are rare, basilar developmental lesions with widespread comorbidities often associated with refractory epilepsy and encephalopathy. Imaging advances allow for early, even prenatal, detection. Genetic studies suggest mutat
Autor:
Timothy E. Green, Mark F. Bennett, Ilka Immisch, Jeremy L. Freeman, Karl Martin Klein, John F. Kerrigan, Lata Vadlamudi, Erin L. Heinzen, Ingrid E. Scheffer, A. Simon Harvey, Felix Rosenow, Michael S. Hildebrand, Samuel F. Berkovic
Publikováno v:
Genetics in Medicine Open. :100810
Autor:
William D. Gaillard, Angus A. Wilfong, Randa Jarrar, Jennifer S Ronecker, Matthew M. Troester, Brian Appavu, Korwyn Williams, Varina L. Boerwinkle, Lucia Mirea, John F. Kerrigan, Diana Larocque, Alexandra Bonnell, Stephen T. Foldes, Bethany L Sussman, P. David Adelson
Publikováno v:
Journal of neurosurgery. Pediatrics.
OBJECTIVEThe authors’ goal was to prospectively quantify the impact of resting-state functional MRI (rs-fMRI) on pediatric epilepsy surgery planning.METHODSFifty-one consecutive patients (3 months to 20 years old) with intractable epilepsy underwen
Publikováno v:
Seminars in Pediatric Neurology. 26:115-118
We report a 10-month-old boy with treatment-resistant infantile spasms associated with hypothalamic hamartoma (HH). Electroencephalography before surgical treatment showed modified hypsarrhythmia. Transventricular endoscopic resection and disconnecti
Publikováno v:
Epilepsy & Behavior. 73:126-130
Objective We conducted a systematic review of the English-language literature to identify clinical features associated with a higher risk of psychiatric symptoms (aggression and rage behaviors) in patients with hypothalamic hamartoma (HH) and epileps
Autor:
Varina L. Boerwinkle, Lucia Mirea, Virendra R. Desai, Jeffrey S. Raskin, Daniel J. Curry, Korwyn Williams, Emilio G. Cediel, John F. Kerrigan, Sandi Lam, P. David Adelson, Angus A. Wilfong
Publikováno v:
Annals of neurologyReferences. 86(3)
OBJECTIVE Postoperative resting-state functional magnetic resonance imaging (MRI) in children with intractable epilepsy has not been quantified in relation to seizure outcome. Therefore, its value as a biomarker for epileptogenic pathology is not wel