Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John F. Kenneke"'
Autor:
Swati Rawat, Satori A. Marchitti, Christopher S. Mazur, Jason Zastre, Caleb M. Dillingham, Anshika Sharma, John F. Kenneke
Publikováno v:
Toxicological Sciences. 155:270-282
High body burdens of polybrominated diphenyl ethers (PBDEs) in infants and young children have led to increased concern over their potential impact on human development. PBDE exposure can alter the expression of genes involved in thyroid homeostasis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886466a08295eb85b6d6874f47a94a2c
https://doi.org/10.1093/toxsci/kfw209
https://doi.org/10.1093/toxsci/kfw209
Publikováno v:
Chirality. 28:633-641
Enantiomers of chiral molecules commonly exhibit differing pharmacokinetics and toxicities, which can introduce significant uncertainty when evaluating biological and environmental fates and potential risks to humans and the environment. However, rac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917de1c8eb2918596d6b49484c4f6d3d
https://doi.org/10.1002/chir.22622
https://doi.org/10.1002/chir.22622
Publikováno v:
Chirality. 28(9)
Enantiomers of chiral molecules commonly exhibit differing pharmacokinetics and toxicities, which can introduce significant uncertainty when evaluating biological and environmental fates and potential risks to humans and the environment. However, rac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::022c022895e4a0fefa65b837c8ed5fca
https://pubmed.ncbi.nlm.nih.gov/27479933
https://pubmed.ncbi.nlm.nih.gov/27479933
Publikováno v:
Environmental Health Perspectives
Background: Serum concentrations of polybrominated diphenyl ethers (PBDEs) in U.S. women are believed to be among the world’s highest; however, little information exists on the partitioning of PBDEs between serum and breast milk and how this may af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745884efb94dd29bc8662e77d6877123
https://pubmed.ncbi.nlm.nih.gov/27405099
https://pubmed.ncbi.nlm.nih.gov/27405099
Publikováno v:
Toxicology Letters. 205:154-162
A physiologically based pharmacokinetic (PBPK) model was developed for the conazole fungicide triadimefon and its primary metabolite, triadimenol. Rat tissue:blood partition coefficients and metabolic constants were measured in vitro for both compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa27a61419098958d535f3798ecacddc
https://doi.org/10.1016/j.toxlet.2011.05.1036
https://doi.org/10.1016/j.toxlet.2011.05.1036
Publikováno v:
Drug Metabolism and Disposition. 38:2232-2238
The extent to which membrane-disrupting agents, such as alamethicin, may alter cofactor transport and influence in vitro kinetic measurements of glucuronidation is a major concern regarding the characterization and extrapolation of inter- and intrasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336aa7da5f74ca012a2f9b2c3d4f8b3b
https://doi.org/10.1124/dmd.110.034819
https://doi.org/10.1124/dmd.110.034819
Publikováno v:
Toxicology Letters. 193:101-107
Understanding the potential differences in metabolic capacity and kinetics between various common laboratory species as well as between genders is an important facet of chemical risk assessment that is often overlooked, particularly for chemicals whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59cdebbfb17219cb5a7a043848527c6
https://doi.org/10.1016/j.toxlet.2009.12.011
https://doi.org/10.1016/j.toxlet.2009.12.011
Publikováno v:
Drug Metabolism and Disposition. 37:1801-1805
Carbonyl containing xenobiotics may be susceptible to NADPH-dependent cytochrome P450 (P450) and carbonyl-reduction reactions. In vitro hepatic microsome assays are routinely supplied NADPH either by direct addition of NADPH or via an NADPH-regenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e1499ede783b8a7f1c0226489af1ff
https://doi.org/10.1124/dmd.109.027615
https://doi.org/10.1124/dmd.109.027615
Publikováno v:
Environmental Science & Technology. 43:5507-5513
Mechanistic and stereoselective based in vitro metabolism assays were utlilized to gain insight into the toxic mode of action of the 1,2,4-triazole fungicide, triadimefon, with black fly (Diptera: Simuliidae) larvae. Based on results from enzyme inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493b5a069d3f0b6882d86f071a696adb
https://doi.org/10.1021/es900351w
https://doi.org/10.1021/es900351w
Autor:
Christopher S. Mazur, John F. Kenneke
Publikováno v:
Environmental Science & Technology. 42:947-954
Ecological risk assessment frequently relies on cross-species extrapolation to predict acute toxicity from chemical exposures. A major concern for environmental risk characterization is the degree of uncertainty in assessing xenobiotic biotransformat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b6539186cd9cd612c243bf23eb801c
https://doi.org/10.1021/es072049b
https://doi.org/10.1021/es072049b