Zobrazeno 1 - 10
of 42
pro vyhledávání: '"John F. Rogers"'
Autor:
Charles William Mann, Lloyd M. Garrick, Matthew D. Vera, Linda Shanno, Jeffrey C. Pelletier, John F. Rogers, Diane B. Hauze, Jay E. Wrobel, Daniel M. Green, Irene Feingold, Murty Chengalvala, John F. Mehlmann, Joseph T. Lundquist, Joshua E. Cottom
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2512-2515
Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists ba
Autor:
Lloyd M. Garrick, John F. Mehlmann, Diane B. Hauze, Joshua E. Cottom, Daniel M. Green, Jeffrey C. Pelletier, Murty Chengalvala, Irene Feingold, Joseph T. Lundquist, John F. Rogers, Charles William Mann, Linda Shanno, Jay E. Wrobel, Christine Huselton, Wenling Kao, Kees Kenneth L
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1986-1990
A previous report described the serum LH suppression pharmacology of the 2-phenyl-4-piperazinyl-benzimidazole N-ethyluracil GnRH receptor antagonist 1 following oral administration in rats. A series of small heterocycles were appended to the 2-(4-ter
Autor:
William R. Adams, Irene Feingold, John F. Mehlmann, Cesario O Tio, Joshua E. Cottom, Jay E. Wrobel, Jeffrey C. Pelletier, Daniel M. Green, John F. Rogers, James W. Jetter, Murty Chengalvala, Joseph T. Lundquist, Charles William Mann, Linda Shanno, Ronald L. Magolda, Diane B. Hauze, Gregory S. Kopf, Christine Huselton
Publikováno v:
Journal of Medicinal Chemistry. 52:2148-2152
A potent, highly insoluble, GnRH antagonist with a 2-phenyl-4-piperazinylbenzimidazole template and a quinoxaline-2,3-dione pharmacophore was modified to maintain GnRH antagonist activity and improve in vitro pharmaceutical properties. Structural cha
Autor:
John F. Rogers, Daniel M. Green
Publikováno v:
Tetrahedron Letters. 43:3585-3587
Useful yields are achieved in the synthesis of phenols from aryl fluorides via a mild one-pot procedure using commercially available 2-(methylsulfonyl)ethanol. Examples and representative yields are shown.
Autor:
John F. Rogers, Daniel M. Green
Publikováno v:
ChemInform. 33
Useful yields are achieved in the synthesis of phenols from aryl fluorides via a mild one-pot procedure using commercially available 2-(methylsulfonyl)ethanol. Examples and representative yields are shown.
Autor:
Jeffrey C. Pelletier, Murty V. Chengalvala, Joshua E. Cottom, Irene B. Feingold, Daniel M. Green, Diane B. Hauze, Christine A. Huselton, James W. Jetter, Gregory S. Kopf, Joseph T. Lundquist, Ronald L. Magolda, Charles W. Mann, John F. Mehlmann, John F. Rogers, Linda K. Shanno, William R. Adams, Cesario O. Tio, Jay E. Wrobel
Publikováno v:
Journal of Medicinal Chemistry; Apr2009, Vol. 52 Issue 7, p2148-2152, 5p
Publikováno v:
Journal of the American Chemical Society. 98:5135-5144
Autor:
John F. Rogers, Luigi X. Cubeddu
Publikováno v:
Clinical Pharmacology and Therapeutics. 34:68-73
Reports on spontaneously hypertensive rats suggested that naloxone blocked the antihypertensive effects of clonidine. We compared the effects of an 8-hr intravenous naloxone infusion (6 micrograms/kg/hr) or 5% dextrose in water (D5/W) begun 2 hr befo
Publikováno v:
Journal of Toxicology: Clinical Toxicology. 19:865-869
Deferoxamine, a specific chelator of ferric iron, has recognized efficacy in the treatment of acute iron overdosage. Toxicological references, however, vary in the preferred route of administration and recommended maximum dosage. A 19-year-old female
Autor:
John F. Rogers, Dennis E. Creasy
Publikováno v:
Journal of Applied Chemistry and Biotechnology. 24:171-180