Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John F Mulvey"'
Autor:
Fenna E M van de Leemkolk, M Letizia Lo Faro, Sadr Shaheed, John F Mulvey, Volkert A L Huurman, Ian P J Alwayn, Hein Putter, Ina Jochmans, Jan H N Lindeman, Rutger J Ploeg, COMPARE Trial Collaboration and the Consortium for Organ Preservation in Europe (COPE)
Publikováno v:
PLoS ONE, Vol 18, Iss 6, p e0287713 (2023)
Hypothermic machine perfusion (HMP) provides preservation superior to cold storage and may allow for organ assessment prior to transplantation. Since flavin mononucleotide (FMN) in perfusate has been proposed as a biomarker of organ quality during HM
Externí odkaz:
https://doaj.org/article/4607a144b8e7400999816a3cc32ebf7c
Autor:
Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102429- (2022)
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administratio
Externí odkaz:
https://doaj.org/article/f01616a12f704ac39a2ca4515711e427
Autor:
Hiran A. Prag, Dunja Aksentijevic, Andreas Dannhorn, Abigail V. Giles, John F. Mulvey, Olga Sauchanka, Luping Du, Georgina Bates, Johannes Reinhold, Duvaraka Kula-Alwar, Zhelong Xu, Luc Pellerin, Richard J. A. Goodwin, Michael P. Murphy, Thomas Krieg
Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for translation to the clinic is understanding the mechanism of malonate entry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0649d78a1a07a97d5d9a744cd65a28
https://eprints.gla.ac.uk/277333/1/277333.pdf
https://eprints.gla.ac.uk/277333/1/277333.pdf
Autor:
James P. Hunter, Letizia Lo Faro, Kaithlyn Rozenberg, Fungai Dengu, Anne Ogbemudia, Annemarie Weissenbacher, John F. Mulvey, Laura Knijff, Kishore Gopalakrishnan, Rutger J. Ploeg
Publikováno v:
Transplant International. 35
Donor kidney assessment may improve organ utilisation. Normothermic Machine Perfusion (NMP) has the potential to facilitate this advance. The mechanism of action is not yet determined and we aimed to assess mitochondrial function during NMP. Anaesthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09064728f94f3385e0a95cecf5d08c32
https://doi.org/10.3389/ti.2022.10420
https://doi.org/10.3389/ti.2022.10420
Autor:
Richard C. Hartley, Marta Loureiro-López, Shujing Ding, Sabine Arndt, Michael P. Murphy, John F. Mulvey, Nils Burger, Abigail A.I. Norman, Kurt Hoogewijs, Olga Sauchanka, Andrew M. James, Ian M. Fearnley, Thomas Krieg, Amin Mottahedin
Publikováno v:
Cell chemical biology. 29(4)
Mammalian complex I can adopt catalytically active (A-) or deactive (D-) states. A defining feature of the reversible transition between these two defined states is thought to be exposure of the ND3 subunit Cys39 residue in the D-state and its occlus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dd32f91e621ba7068e974d8fec5a56
https://pubmed.ncbi.nlm.nih.gov/34739852
https://pubmed.ncbi.nlm.nih.gov/34739852
Autor:
Thomas Krieg, Tim M. Young, Michael J. Shattock, Andrew M. James, Luc Pellerin, Dunja Aksentijevic, John F. Mulvey, Hiran A. Prag, Margaret M. Huang, Christian Frezza, Kourosh Saeb-Parsy, Efterpi Nikitopoulou, Michael P. Murphy, Raimondo Ascione, Timothy E. Beach, Laura Tronci, Anna Hadjihambi, Anja V. Gruszczyk
Publikováno v:
Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2021, 117 (4), pp.1188-1201. ⟨10.1093/cvr/cvaa148⟩
Prag, H A, Gruszczyk, A V, Huang, M M, Beach, T E, Young, T, Tronci, L, Nikitopoulou, E, Mulvey, J F, Ascione, R, Hadjihambi, A, Shattock, M J, Pellerin, L, Saeb-Parsy, K, Frezza, C, James, A M, Krieg, T, Murphy, M P & Aksentijević, D 2020, ' Mechanism of succinate efflux upon reperfusion of the ischemic heart ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvaa148
Cardiovascular Research, Oxford University Press (OUP), 2021, 117 (4), pp.1188-1201. ⟨10.1093/cvr/cvaa148⟩
Prag, H A, Gruszczyk, A V, Huang, M M, Beach, T E, Young, T, Tronci, L, Nikitopoulou, E, Mulvey, J F, Ascione, R, Hadjihambi, A, Shattock, M J, Pellerin, L, Saeb-Parsy, K, Frezza, C, James, A M, Krieg, T, Murphy, M P & Aksentijević, D 2020, ' Mechanism of succinate efflux upon reperfusion of the ischemic heart ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvaa148
Aims Succinate accumulates several-fold in the ischaemic heart and is then rapidly oxidized upon reperfusion, contributing to reactive oxygen species production by mitochondria. In addition, a significant amount of the accumulated succinate is releas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5795a484c5081eead9896f803809cb6
https://hal-cnrs.archives-ouvertes.fr/hal-03366637/document
https://hal-cnrs.archives-ouvertes.fr/hal-03366637/document
Autor:
Moises Di Sante, Fabio Di Lisa, Richard C. Hartley, Thomas Krieg, Anja V. Gruszczyk, Andrew R. Hall, Nils Burger, John F. Mulvey, Elizabeth C. Hinchy, Michael P. Murphy, Stuart T. Caldwell, Nina Kaludercic, Soni Deshwal, Salvatore Antonucci
Publikováno v:
Free Radical Biology & Medicine
Reactive oxygen species (ROS) have an equivocal role in myocardial ischaemia reperfusion injury. Within the cardiomyocyte, mitochondria are both a major source and target of ROS. We evaluate the effects of a selective, dose-dependent increase in mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df404c5f48b6843945815be65fb4b02d
https://www.repository.cam.ac.uk/handle/1810/289661
https://www.repository.cam.ac.uk/handle/1810/289661
Autor:
Amin Mottahedin, Nils Burger, Thomas Krieg, Bijan Ghaleh, Christian Frezza, John F. Mulvey, Renaud Tissier, Matthias Kohlhauer, Ana-Mishel Spiroski, Anja V. Gruszczyk, Michael P. Murphy, Ana S. H. Costa, Victoria R. Pell
Publikováno v:
Basic Research in Cardiology. 114
Hypothermia induced at the onset of ischemia is a potent experimental cardioprotective strategy for myocardial infarction. The aim of our study was to determine whether the beneficial effects of hypothermia may be due to decreasing mitochondria-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26b13f45a879dfed1ebb8a6301d73da6
https://doi.org/10.1007/s00395-019-0727-0
https://doi.org/10.1007/s00395-019-0727-0
Autor:
Michael P. Murphy, Andrew M. James, Nils Burger, Victoria R. Pell, Ana-Mishel Spiroski, Tiziana Rosa, Thomas Krieg, Anja V. Gruszczyk, Christian Frezza, John F. Mulvey, Ana S. H. Costa, Angela Logan
Publikováno v:
Pell, V R, Spiroski, A-M, Mulvey, J, Burger, N, Costa, A S H, Logan, A, Gruszczyk, A V, Rosa, T, James, A M, Frezza, C, Murphy, M P & Krieg, T 2018, ' Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation ', Journal of Molecular and Cellular Cardiology, vol. 123 . https://doi.org/10.1016/j.yjmcc.2018.08.010
Ischemia-reperfusion (IR) injury occurs when blood supply to an organ is disrupted and then restored, and underlies many disorders, notably myocardial infarction and stroke. While reperfusion of ischemic tissue is essential for survival, it also init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5faaaf64930463caf5e8b6c8ad5fea2e
https://pubmed.ncbi.nlm.nih.gov/30118790
https://pubmed.ncbi.nlm.nih.gov/30118790
Autor:
Alina Hanf, Alberto Bindoli, Miloš Mojović, David A. Bernlohr, Yuliya Mikhed, Paula M. Brito, Agnes Görlach, João G. Costa, Vladimír Křen, Rui M. Barbosa, Jose Viña, Khrystyna Semen, María Monsalve, Opeyemi S Ademowo, Andreas Petry, Jingjing Huang, Balaraman Kalyanaraman, Ioanna Andreadou, Javier Egea, Kateryna Kubaichuk, Antonio Martínez-Ruiz, Mutay Aslan, Helen R. Griffiths, Pietro Ghezzi, S. Ilikay, Rashid Giniatullin, Melanie Hillion, Shlomo Sasson, Verónica Miguel, John F. Mulvey, Huige Li, Nuno Saraiva, Kemal Sami Korkmaz, Brandán Pedre, Isabel T.N. Nguyen, Katrin Schröder, Maria Pia Rigobello, Holger Steinbrenner, João Laranjinha, Nikoletta Papaevgeniou, Péter Ferdinandy, Kateřina Valentová, Andrew R. Pitt, Nuno G. Oliveira, Amanda J. Edson, Gratiela Gradisteanu Pircalabioru, Paul G. Winyard, Matthias Oelze, Irundika H.K. Dias, Thomas Krieg, Joris Messens, Pidder Jansen-Dürr, Vaclav Hampl, Fernando Antunes, Yves Frapart, Thierry Soldati, Bilge Debelec-Butuner, Anabela P. Rolo, Tilman Grune, Jan Vacek, Thomas Münzel, Kahina Abbas, Marina Kleanthous, Anastasia Shakirzyanova, Neven Žarković, Belma Turan, Olga Vajnerova, F. Di Lisa, Irina Milisav, Thomas Kietzmann, Rhian M. Touyz, Lidija Milkovic, Antonio Cuadrado, Pierre-Alexis Mouthuy, Serge P. Bottari, Karl-Heinz Krause, Francis Rousset, Reiko Matsui, Catarina B. Afonso, Danylo Kaminskyy, Bebiana C. Sousa, F. Van Breusegem, Ana Sofia Fernandes, Antigone Lazou, Marcus Conrad, Isabel Fabregat, Bato Korac, Pablo Hernansanz-Agustín, Aleksandra Pavićević, Jaap A. Joles, Erkan Tuncay, Fabienne Peyrot, Anikó Görbe, Sebastian Steven, Harald H.H.W. Schmidt, Martina Zatloukalová, Jan Herget, Santiago Lamas, Kari E. Fladmark, Markus Bachschmid, Afroditi Chatzi, Geoffrey L. Smith, Fulvio Ursini, Joe Dan Dunn, Kostas Tokatlidis, Rafal Koziel, Andreas Papapetropoulos, Antonio Miranda-Vizuete, Jamel El-Benna, Vincent Jaquet, B. De Smet, Vladimir R. Muzykantov, Elizabeth A. Veal, Esther Bertran, Guia Carrara, Olha Yelisyeyeva, Haike Antelmann, Ana Stancic, A. S. Yalçin, M. El Assar, Ulla G. Knaus, Marcus S. Cooke, Vsevolod V. Belousov, Leocadio Rodríguez-Mañas, Lars-Oliver Klotz, Marios Phylactides, Manuela G. López, Marie José Stasia, Tatjana Ruskovska, Stuart P. Meredith, Lokman Varisli, Niki Chondrogianni, Mahsa Karbaschi, Rainer Schulz, Henrik E. Poulsen, Andreas Daiber, Natalia Robledinos-Antón, Corinne M. Spickett, Ulrich Förstermann, Višnja Stepanić, Tamara Seredenina, Carlos M. Palmeira, Gloria Olaso-Gonzalez, Ana I. Casas, Ignacio Prieto, Gethin J. McBean, Damir Kračun, P. My-Chan Dang, Jacek Zielonka, Zoltán Giricz, Carsten Berndt
Publikováno v:
Redox Biology
Redox Biology, Vol 14, Iss, Pp 694-696 (2018)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox biology, 14, 694. Elsevier BV
Redox Biology, Vol 14, Iss, Pp 694-696 (2018)
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox biology, 14, 694. Elsevier BV
The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7922a8fee818046981b1246741e4ea