Zobrazeno 1 - 10
of 243
pro vyhledávání: '"John F Hunt"'
Autor:
Ryan G Thomas, Brenda M Rivera Reyes, Benjamin M Gaston, Nelki B Rivera Acosta, Ilya R Bederman, Laura A Smith, Morgan T Sutton, Benlian Wang, John F Hunt, Tracey L Bonfield
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188614 (2017)
BACKGROUND:An association of acetaminophen use and asthma was observed in the International Study of Asthma and Allergies in Childhood study. However there are no clear mechanisms to explain an association between acetaminophen use and immunologic pa
Externí odkaz:
https://doaj.org/article/54d6df6766d446e29c11747a3118758c
Autor:
Indigo Chris King, James Gleixner, Lindsey Doyle, Alexandre Kuzin, John F Hunt, Rong Xiao, Gaetano T Montelione, Barry L Stoddard, Frank DiMaio, David Baker
Publikováno v:
eLife, Vol 4 (2015)
Design of complex alpha-beta protein topologies poses a challenge because of the large number of alternative packing arrangements. A similar challenge presumably limited the emergence of large and complex protein topologies in evolution. Here, we dem
Externí odkaz:
https://doaj.org/article/57fd6a24295a4b37807755b9fec17224
Publikováno v:
Materials, Vol 10, Iss 2, p 185 (2017)
This paper presents experimental results of both quasi-static compression and low-velocity impact behavior for tri-axial bio-composite structural panels using a spherical load head. Panels were made having different core and face configurations. The
Externí odkaz:
https://doaj.org/article/2ab9f0ca8eb84c3f92a604d93d305f28
Autor:
Andrew E Bruno, Amanda M Ruby, Joseph R Luft, Thomas D Grant, Jayaraman Seetharaman, Gaetano T Montelione, John F Hunt, Edward H Snell
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100782 (2014)
Many bioscience fields employ high-throughput methods to screen multiple biochemical conditions. The analysis of these becomes tedious without a degree of automation. Crystallization, a rate limiting step in biological X-ray crystallography, is one o
Externí odkaz:
https://doaj.org/article/dde777582b5349c8a764b52b92a6b7a4
Autor:
Dipak N. Patil, Shikha Singh, Thibaut Laboute, Timothy S. Strutzenberg, Xingyu Qiu, Di Wu, Scott J. Novick, Carol V. Robinson, Patrick R. Griffin, John F. Hunt, Tina Izard, Appu K. Singh, Kirill A. Martemyanov
Publikováno v:
Science
Not your typical GPCR Among the large family of G protein–coupled receptors (GPCRs) are many orphans, so called because their signaling reactions remain poorly understood. Among these is GPR158 which is highly expressed in the nervous system and im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493ed2eac91bdbd9a1a19a0ab84f5be4
https://pubmed.ncbi.nlm.nih.gov/34793198
https://pubmed.ncbi.nlm.nih.gov/34793198
Autor:
Lingwei Zhu, Jinrang Kim, Kun Leng, John E. Ramos, Colin D. Kinz-Thompson, Nathan K. Karpowich, Ruben L. Gonzalez, John F. Hunt
ATP-BindingCassette (ABC) Transporters employ homologous ATPase domains to drive transmembrane transport of diverse substrates ranging from small molecules to large polymers. Bacterial ABC importers require an extramembranoussubstratebindingprotein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429dead4a09dd83983e6f77076a83b53
https://doi.org/10.1101/2022.12.02.518933
https://doi.org/10.1101/2022.12.02.518933
Autor:
Lingwei Zhu, Jinrang Kim, Kun Leng, John E. Ramos, Colin D. Kinz-Thompson, Nathan K. Karpowich, Ruben L. Gonzalez, John F. Hunt
ATP-BindingCassette (ABC) Transporters use ATP binding and hydrolysis to power transmembrane transport of chemically diverse substrates. Current knowledge of their mechanism comes primarily from static structures of stable intermediates along the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bebadc1e4918e4c609b254eb55e78e9
https://doi.org/10.1101/2022.12.02.518935
https://doi.org/10.1101/2022.12.02.518935
Autor:
Chi Wang, Zhengrong Yang, Blaine J. Loughlin, Haijin Xu, Guido Veit, Sergey Vorobiev, Oliver B. Clarke, Fan Jiang, Yaohui Li, Shikha Singh, Zachary Rich, Elizabeth R. Menten, Robert A. Grassucci, Wei Wang, Allison Mezzell, Ziao Fu, Kam-Ho Wong, Jing Wang, Diana R. Wetmore, R. Bryan Sutton, Christie G. Brouillette, Ina L. Urbatsch, John C. Kappes, Gergely L. Lukacs, Joachim Frank, John F. Hunt
Cystic fibrosis (CF) is caused by mutations in a chloride channel called the human Cystic Fibrosis Transmembrane Conductance Regulator (hCFTR). We used cryo-EM global conformational ensemble reconstruction to characterize the mechanism by which the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8099769d8252d91e0952af46cc5ab09
https://doi.org/10.1101/2022.10.10.510913
https://doi.org/10.1101/2022.10.10.510913
Autor:
Yaohui Li, Rongzhen Zhang, Chi Wang, Farhad Forouhar, Oliver B Clarke, Sergey Vorobiev, Shikha Singh, Gaetano T Montelione, Thomas Szyperski, Yan Xu, John F Hunt
Publikováno v:
The EMBO Journal. 41
The evolutionary benefit accounting for widespread conservation of oligomeric structures in proteins lacking evidence of intersubunit cooperativity remains unclear. Here, crystal and cryo-EM structures, and enzymological data, demonstrate that a cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5a269fa81a57b8afd93d3b8c14835e
https://doi.org/10.15252/embj.2021108368
https://doi.org/10.15252/embj.2021108368
Autor:
Malkeet Singh Bahia, Eric J. Sorscher, Andras Rab, Jeong S. Hong, Hanoch Senderowitz, Netaly Khazanov, John F. Hunt, Zhengrong Yang, Chi Wang, Qingxian Zhou, Christie G. Brouillette
Publikováno v:
Journal of Chemical Information and Modeling. 61:1762-1777
Cystic Fibrosis (CF) is caused by mutations to the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel. CFTR is composed of two membrane spanning domains, two cytosolic nucleotide-binding domains (NBD1 and NBD2) and a largely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1225adc881ac1257c61d8141da3a6901
https://doi.org/10.1021/acs.jcim.0c01207
https://doi.org/10.1021/acs.jcim.0c01207