Zobrazeno 1 - 10
of 255
pro vyhledávání: '"John F Hancock"'
Autor:
Maja Šolman, Alessio Ligabue, Olga Blaževitš, Alok Jaiswal, Yong Zhou, Hong Liang, Benoit Lectez, Kari Kopra, Camilo Guzmán, Harri Härmä, John F Hancock, Tero Aittokallio, Daniel Abankwa
Publikováno v:
eLife, Vol 4 (2015)
Hotspot mutations of Ras drive cell transformation and tumorigenesis. Less frequent mutations in Ras are poorly characterized for their oncogenic potential. Yet insight into their mechanism of action may point to novel opportunities to target Ras. He
Externí odkaz:
https://doaj.org/article/a84df42c6ba14fc0a17e36dc361c148f
Autor:
Yann Gambin, Nicholas Ariotti, Kerrie-Ann McMahon, Michele Bastiani, Emma Sierecki, Oleksiy Kovtun, Mark E Polinkovsky, Astrid Magenau, WooRam Jung, Satomi Okano, Yong Zhou, Natalya Leneva, Sergey Mureev, Wayne Johnston, Katharina Gaus, John F Hancock, Brett M Collins, Kirill Alexandrov, Robert G Parton
Publikováno v:
eLife, Vol 3 (2014)
In mammalian cells three closely related cavin proteins cooperate with the scaffolding protein caveolin to form membrane invaginations known as caveolae. Here we have developed a novel single-molecule fluorescence approach to directly observe interac
Externí odkaz:
https://doaj.org/article/3222892030ff4bd78593681b9cee2d10
Autor:
Michelle M Hill, Noor Huda Daud, Cho Sanda Aung, Dorothy Loo, Sally Martin, Samantha Murphy, Debra M Black, Rachael Barry, Fiona Simpson, Libin Liu, Paul F Pilch, John F Hancock, Marie-Odile Parat, Robert G Parton
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43041 (2012)
Caveolin-1 and caveolae are differentially polarized in migrating cells in various models, and caveolin-1 expression has been shown to quantitatively modulate cell migration. PTRF/cavin-1 is a cytoplasmic protein now established to be also necessary
Externí odkaz:
https://doaj.org/article/f55dfb02b458465fb7e9fce071638f91
Autor:
Barak Rotblat, Liron Belanis, Hong Liang, Roni Haklai, Galit Elad-Zefadia, John F Hancock, Yoel Kloog, Sarah J Plowman
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e11991 (2010)
H-Ras is a binary switch that is activated by multiple co-factors and triggers several key cellular pathways one of which is MAPK. The specificity and magnitude of downstream activation is achieved by the spatio-temporal organization of the active H-
Externí odkaz:
https://doaj.org/article/fbdd193deaeb46c6887ac1cbb7e04925
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8811 (2010)
The nonsteroidal anti-inflammatory drug (NSAID), indomethacin (Indo), has a large number of divergent biological effects, the molecular mechanism(s) for which have yet to be fully elucidated. Interestingly, Indo is highly amphiphilic and associates s
Externí odkaz:
https://doaj.org/article/ad87abd67f7c44f39cd64a043a93622a
Autor:
Junchen Liu, Ransome van der Hoeven, Walaa E. Kattan, Jeffrey T. Chang, Dina Montufar-Solis, Wei Chen, Maurice Wong, Yong Zhou, Carlito B. Lebrilla, John F. Hancock
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
KRAS is a small GTPase that regulates cell proliferation. Here, the authors show that a subset of cell surface glycosphingolipids regulate KRAS plasma membrane localization by modulating inner leaflet lipid composition, uncovering a requirement for K
Externí odkaz:
https://doaj.org/article/7c042b78ee0049b58df0d81f70b376de
Publikováno v:
European Medical Journal, Pp 127-133 (2022)
Neratinib was developed as an irreversible catalytic inhibitor of ERBB2, which also acts to inhibit ERBB1 and ERBB4. Neratinib is U.S. Food and Drug Administration (FDA)-approved as a neo-adjuvant therapy for use in HER2+ breast cancer. More recently
Externí odkaz:
https://doaj.org/article/cdacbc83be84411aa1963794eeb48ed3
Autor:
Jewon Jung, Han Liao, Shannon A. Coker, Hong Liang, John F. Hancock, Catherine Denicourt, Kartik Venkatachalam
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102701- (2021)
Summary: Inhibition of TRPML1, which is encoded by MCOLN1, is known to deter cell proliferation in various malignancies. Here, we report that the tumor suppressor, p53, represses MCOLN1 in the urothelium such that either the constitutive loss or ecto
Externí odkaz:
https://doaj.org/article/95fdf0922c1f4d27bd5efa42a122fd59
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
RAS proteins are lipid-anchored small GTPases that switch between the GTP-bound active and GDP-bound inactive states. RAS isoforms, including HRAS, NRAS and splice variants KRAS4A and KRAS4B, are some of the most frequently mutated proteins in cancer
Externí odkaz:
https://doaj.org/article/d8efe9971a0047c0a523a692998e094a
Publikováno v:
Molecular Cell. 83:1210-1215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56ddbecd88dbadc1b6abc82df18ebbfe
https://doi.org/10.1016/j.molcel.2023.03.008
https://doi.org/10.1016/j.molcel.2023.03.008