Zobrazeno 1 - 10
of 389
pro vyhledávání: '"John F Engelhardt"'
Publikováno v:
PLoS Pathogens, Vol 12, Iss 1, p e1005399 (2016)
Human bocavirus 1 (HBoV1) belongs to the genus Bocaparvovirus of the Parvoviridae family, and is an emerging human pathogenic respiratory virus. In vitro, HBoV1 infects well-differentiated/polarized primary human airway epithelium (HAE) cultured at a
Externí odkaz:
https://doaj.org/article/dcb1020c3c924bbdbab97a96858a26d2
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116756 (2015)
Airway submucosal glands contribute to innate immunity and protect the lungs by secreting mucus, which is required for mucociliary clearance and which also contains antimicrobial, anti-inflammatory, anti-proteolytic and anti-oxidant proteins. We stim
Externí odkaz:
https://doaj.org/article/6626ede845eb43dfb7a8bdcc507ef5d3
Autor:
Hongshu Sui, Yaling Yi, Jianrong Yao, Bo Liang, Xingshen Sun, Shanming Hu, Aliye Uc, Deborah J Nelson, Katie Larson Ode, Louis H Philipson, John F Engelhardt, Andrew W Norris
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90519 (2014)
Ferrets are an important emerging model of cystic fibrosis related diabetes. However, there is little documented experience in the use of advanced techniques to quantify aspects of diabetes pathophysiology in the ferret. Glycemic clamps are the gold
Externí odkaz:
https://doaj.org/article/bb25f996055e47678ff1fd0d26ef77c4
Autor:
Yinghua Tang, Mehrnoosh Ebadi, Junying Lei, Zehua Feng, Shahab Fakhari, Peipei Wu, Mark D. Smith, Maria P. Limberis, Roland Kolbeck, Katherine J. Excoffon, Ziying Yan, John F. Engelhardt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101244- (2024)
The dosing interval for effective recombinant adeno-associated virus (rAAV)-mediated gene therapy of cystic fibrosis lung disease remains unknown. Here, we assessed the durability of rAAV2.5T-fCFTRΔR-mediated transgene expression and neutralizing an
Externí odkaz:
https://doaj.org/article/27a6b1d9b32d4d5fbd5e3361073b18ed
Autor:
Yoko Nakano, Israt Jahan, Gregory Bonde, Xingshen Sun, Michael S Hildebrand, John F Engelhardt, Richard J H Smith, Robert A Cornell, Bernd Fritzsch, Botond Bánfi
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1002966 (2012)
Sensory hair cells are essential for hearing and balance. Their development from epithelial precursors has been extensively characterized with respect to transcriptional regulation, but not in terms of posttranscriptional influences. Here we report o
Externí odkaz:
https://doaj.org/article/4395de36243a4f22b30171381a962a14
Autor:
Dawne N Shelton, Hubert Fornalik, Traci Neff, Soo Yeun Park, David Bender, Koen DeGeest, Xiaoming Liu, Weiliang Xie, David K Meyerholz, John F Engelhardt, Michael J Goodheart
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40312 (2012)
Endometrial carcinoma is the most common gynecologic cancer, yet the mechanisms underlying this disease process are poorly understood. We hypothesized that Lef1 is required for endometrial gland formation within the uterus and is overexpressed in end
Externí odkaz:
https://doaj.org/article/f478f668d4dc464a96e50da2e8a98216
Autor:
Qinfeng Huang, Xuefeng Deng, Ziying Yan, Fang Cheng, Yong Luo, Weiran Shen, Diana C M Lei-Butters, Aaron Yun Chen, Yi Li, Liang Tang, Maria Söderlund-Venermo, John F Engelhardt, Jianming Qiu
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002899 (2012)
Human bocavirus 1 (HBoV1) has been identified as one of the etiological agents of wheezing in young children with acute respiratory-tract infections. In this study, we have obtained the sequence of a full-length HBoV1 genome (including both termini)
Externí odkaz:
https://doaj.org/article/a46440730cea47b983b307413a4c7d74
Autor:
David K. Meyerholz, Mariah R. Leidinger, J. Adam Goeken, Thomas R. Businga, Sebastian Vizuett, Allison Akers, Idil Evans, Yan Zhang, John F. Engelhardt
Publikováno v:
BMC Research Notes, Vol 16, Iss 1, Pp 1-7 (2023)
Abstract Objective Cystic fibrosis (CF) is a genetic condition that causes abnormal mucus secretions in affected organs. MUC5AC and MUC5B are gel-forming mucins and frequent targets for investigations in CF tissues. Our objective was to qualify MUC5A
Externí odkaz:
https://doaj.org/article/174b53258e0b4b63aa26194e516729bd
Autor:
Yinghua Tang, Shahab Fakhari, Eric D. Huntemann, Zehua Feng, Peipei Wu, William Y. Feng, Junying Lei, Feng Yuan, Katherine J. Excoffon, Kai Wang, Maria P. Limberis, Roland Kolbeck, Ziying Yan, John F. Engelhardt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 70-80 (2023)
The efficacy of redosing the recombinant adeno-associated virus (rAAV) vector rAAV2.5T to ferret lung is limited by AAV neutralizing antibody (NAb) responses. While immunosuppression strategies have allowed for systemic rAAV repeat dosing, their util
Externí odkaz:
https://doaj.org/article/1cbaa351bc964c2ea2b39626805cbbeb
Autor:
Weam S. Shahin, Shima O. Ebed, Scott R. Tyler, Branko Miljkovic, Soon H. Choi, Yulong Zhang, Weihong Zhou, Idil A. Evans, Charles Yeaman, John F. Engelhardt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
How reactive oxygen species regulate neuronal stem cell (NSC) behavior is poorly understood. Here, the authors report that Ncf1-dependent oxidation of Igfbp2 cystines represses DNA repair networks to regulate NSC self-renewal and cell fate decisions.
Externí odkaz:
https://doaj.org/article/985d4b05b2564aa19e3260b66b59d420