Zobrazeno 1 - 10
of 238
pro vyhledávání: '"John F Disterhoft"'
Publikováno v:
eLife, Vol 9 (2020)
Whether and how persistent firing in lateral entorhinal cortex layer III (LEC III) supports temporal associative learning is still unknown. In this study, persistent firing was evoked in vitro from LEC III neurons from young and aged rats that were b
Externí odkaz:
https://doaj.org/article/55d9ef25823c40a1b8c0055f66d17466
Publikováno v:
eLife, Vol 6 (2017)
The molecular mechanisms underlying age-related cognitive deficits are not yet fully elucidated. In aged animals, a decrease in the intrinsic excitability of CA1 pyramidal neurons is believed to contribute to age-related cognitive impairments. Increa
Externí odkaz:
https://doaj.org/article/4298f30a45ca434e9c54ba53de1905da
Autor:
Craig eWeiss, John F Disterhoft
Publikováno v:
Frontiers in Psychiatry, Vol 6 (2015)
Analysis of data collected from behavioral paradigms has provided important information for understanding the etiology and progression of diseases that involve neural regions mediating abnormal behavior. The trace eyeblink conditioning (EBC) paradigm
Externí odkaz:
https://doaj.org/article/d0c01635345a43e8b988e76368e62e37
Autor:
Kevin T Gobeske, Sunit Das, Michael A Bonaguidi, Craig Weiss, Jelena Radulovic, John F Disterhoft, John A Kessler
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7506 (2009)
Exposure to exercise or to environmental enrichment increases the generation of new neurons in the adult hippocampus and promotes certain kinds of learning and memory. While the precise role of neurogenesis in cognition has been debated intensely, co
Externí odkaz:
https://doaj.org/article/0e52294ec51d4b37a42a60e409ad8a2c
Autor:
Craig Weiss, Nicola Bertolino, Daniele Procissi, Grazia Aleppo, Quinn C. Smith, Kirsten L. Viola, Samuel C. Bartley, William L. Klein, John F. Disterhoft
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Although mouse models of Alzheimer's disease (AD) have increased our understanding of the molecular basis of the disease, none of those models represent late‐onset Alzheimer's Disease which accounts for >90% of AD cases, and n
Externí odkaz:
https://doaj.org/article/4cd0d89d401245cc9ddee8795292d543
Autor:
Birsu Bac, Cheima Hicheri, Craig Weiss, Amelia Buell, Natalia Vilcek, Claudia Spaeni, Changiz Geula, Jeffrey N. Savas, John F. Disterhoft
Publikováno v:
Neurobiology of Aging. 123:98-110
Publikováno v:
Hippocampus. 32:776-794
Because the dentate gyrus serves as the first site for information processing in the hippocampal trisynaptic circuit, it an important structure for the formation of associative memories. Previous findings in rabbit had recorded populations of cells w
Publikováno v:
J Neurosci
Calcium imaging using GCaMP indicators and miniature microscopes has been used to image cellular populations during long timescales and in different task phases, as well as to determine neuronal circuit topology and organization. Because the hippocam
Autor:
Yuliya Voskobiynyk, Timothy F. Musial, Gary X. D'Souza, Daniel A. Nicholson, Viviana Jimenez, Natividad Ybarra, Annalise E. Rogalsky, Loreece G. Haddad, John F. Disterhoft, Elizabeth Molina-Campos, Matthew L. Russo, Dane M. Chetkovich, Gabriel Carballo, M. Matthew Oh, Krystina M. Neuman
Publikováno v:
Neurobiology of Aging. 106:207-222
The hippocampus is vulnerable to deterioration in Alzheimer's disease (AD). It is, however, a heterogeneous structure, which may contribute to the differential volumetric changes along its septotemporal axis during AD progression. Here, we investigat
Publikováno v:
HippocampusREFERENCES.
A challenge in both modern and historic neuroscience has been achieving an understanding of neuron circuits, and determining the computational and organizational principles that underlie these circuits. Deeper understanding of the organization of bra