Výsledky vyhledávání - "John F Boylan"

Akademický článek

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.

Autor: Brenden Chen, Christine Tardell, Brian Higgins, Kathryn Packman, John F Boylan, Huifeng Niu

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42598 (2012)

Cross-feedback activation of MAPK and AKT pathways is implicated as a resistance mechanism for cancer therapeutic agents targeting either RAF/MEK or PI3K/AKT/mTOR. It is thus important to have a better understanding of the molecular resistance mechan

Externí odkaz: https://doaj.org/article/f977105d31fa4f8f9f44e379c7007545

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Akademický článek

The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.

Autor: Chanh Huynh, Laura Poliseno, Miguel F Segura, Ratna Medicherla, Adele Haimovic, Silvia Menendez, Shulian Shang, Anna Pavlick, Yongzhao Shao, Farbod Darvishian, John F Boylan, Iman Osman, Eva Hernando

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25264 (2011)

Several reports have demonstrated a role for aberrant NOTCH signaling in melanoma genesis and progression, prompting us to explore if targeting this pathway is a valid therapeutic approach against melanoma. We targeted NOTCH signaling using RO4929097

Externí odkaz: https://doaj.org/article/9d30d0ca44aa4f2587ae02ce7501142d

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