Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism

Autor: John F. Dou, Rebecca J. Schmidt, Heather E. Volk, Manon M. Nitta, Jason I. Feinberg, Craig J. Newschaffer, Lisa A. Croen, Irva Hertz-Picciotto, M. Daniele Fallin, Kelly M. Bakulski

Publikováno v: Environmental Health, Vol 23, Iss 1, Pp 1-13 (2024)

Abstract Background Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder. Risk is attributed to genetic and prenatal environmental factors, though the environmental agents are incompletely characterized. Methods

Externí odkaz: https://doaj.org/article/e7f2c5eee2224464bfb40be04f6ac34b

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autor: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melén, Gemma C. Sharp, Matt J. Silver, Faisal I. Rezwan, John W. Holloway

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)

Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms under

Externí odkaz: https://doaj.org/article/d655547609c94f51b01a2521002c970a

Sex-specific DNA methylation in saliva from the multi-ethnic Future of Families and Child Wellbeing Study

Autor: Allison Reiner, Kelly M. Bakulski, Jonah D. Fisher, John F Dou, Lisa Schneper, Colter Mitchell, Daniel A. Notterman, Matthew Zawistowski, Erin B. Ware

Publikováno v: Epigenetics, Vol 18, Iss 1 (2023)

The prevalence and severity of many diseases differs by sex, potentially due to sex-specific patterns in DNA methylation. Autosomal sex-specific differences in DNA methylation have been observed in cord blood and placental tissue but are not well stu

Externí odkaz: https://doaj.org/article/f8c8a016d4844733a5bd7e324d0e2d75

A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health

Autor: Nora Fernandez-Jimenez, Ruby Fore, Ariadna Cilleros-Portet, Johanna Lepeule, Patrice Perron, Tuomas Kvist, Fu-Ying Tian, Corina Lesseur, Alexandra M. Binder, Manuel Lozano, Jordi Martorell-Marugán, Yuk J. Loke, Kelly M. Bakulski, Yihui Zhu, Anne Forhan, Sara Sammallahti, Todd M. Everson, Jia Chen, Karin B. Michels, Thalia Belmonte, Pedro Carmona-Sáez, Jane Halliday, M. Daniele Fallin, Janine M. LaSalle, Jorg Tost, Darina Czamara, Mariana F. Fernández, Antonio Gómez-Martín, Jeffrey M. Craig, Beatriz Gonzalez-Alzaga, Rebecca J. Schmidt, John F. Dou, Evelyne Muggli, Marina Lacasaña, Martine Vrijheid, Carmen J. Marsit, Margaret R. Karagas, Katri Räikkönen, Luigi Bouchard, Barbara Heude, Loreto Santa-Marina, Mariona Bustamante, Marie-France Hivert, Jose Ramon Bilbao

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)

A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic

Externí odkaz: https://doaj.org/article/25f6e68216ef415aa23b5efa7f8762a9

Maternal blood metal concentrations and whole blood DNA methylation during pregnancy in the Early Autism Risk Longitudinal Investigation (EARLI)

Autor: Max T. Aung, Kelly M. Bakulski, Jason I. Feinberg, John F. Dou, John D. Meeker, Bhramar Mukherjee, Rita Loch-Caruso, Christine Ladd-Acosta, Heather E. Volk, Lisa A. Croen, Irva Hertz-Picciotto, Craig J. Newschaffer, M. Daniele Fallin

Publikováno v: Epigenetics, Vol 17, Iss 3, Pp 253-268 (2022)

The maternal epigenome may be responsive to prenatal metals exposures. We tested whether metals are associated with concurrent differential maternal whole blood DNA methylation. In the Early Autism Risk Longitudinal Investigation cohort, we measured

Externí odkaz: https://doaj.org/article/6ab337b726944212b28dba1b8fe8089f