Zobrazeno 1 - 10
of 280
pro vyhledávání: '"John F, Atkins"'
Autor:
Simon A. Fromm, Kate M. O’Connor, Michael Purdy, Pramod R. Bhatt, Gary Loughran, John F. Atkins, Ahmad Jomaa, Simone Mattei
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Developments in cryo-EM sample preparation and data collection are pivotal for structure determination. Fromm et al. present a 1.55 Å structure of the translating bacterial ribosome that provides new insights on its function and may allow for more p
Externí odkaz:
https://doaj.org/article/8b19dbac922a48bb8c1937b73fc110d6
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Altered mito-ribosomal fidelity is an important and insufficiently understood causative agent of mitochondrial dysfunction. Its pathogenic effects are particularly well-known in the case of mitochondrially induced deafness, due to the existence of th
Externí odkaz:
https://doaj.org/article/b007bea67dea44718b4113efbed4a61a
Autor:
Christophe Penno, Mary O’Connell Motherway, Yuan Fu, Virag Sharma, Fiona Crispie, Paul D. Cotter, Benoit Houeix, Lokesh Joshi, Francesca Bottacini, Aoife O’Dwyer, Gary Loughran, John F. Atkins, Douwe van Sinderen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The human gut microbiome, of which the genus Bifidobacterium is a prevalent and abundant member, is thought to sustain and enhance human health. Several surface-exposed structures, including so-called sortase-dependent pili, represent import
Externí odkaz:
https://doaj.org/article/bc3969c2a76447c09958da50179cacdf
Publikováno v:
Wellcome Open Research, Vol 5 (2022)
Abstract Background: Previously we reported the discovery of stop codon readthrough in AMD1 mRNA followed by ribosome stalling at the end of a conserved Open Reading Frame (ORF) that we termed AMD1. To explain the severe suppression of reporters fuse
Externí odkaz:
https://doaj.org/article/26be2f3e6da746988e14f013438efe8c
Publikováno v:
Nucleic Acids Research. 51:304-314
A stop codon entering the ribosome A-site is normally decoded by release factors that induce release of the polypeptide. Certain factors influence the efficiency of the termination which is in competition with elongation in either the same (readthrou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e38c109a836d75764ec69a9b1adc6e
https://doi.org/10.1093/nar/gkac1180
https://doi.org/10.1093/nar/gkac1180
Publikováno v:
Biology Direct, Vol 12, Iss 1, Pp 1-16 (2017)
Abstract Background Programmed ribosomal frameshifting (PRF) is a gene expression mechanism which enables the translation of two N-terminally coincident, C-terminally distinct protein products from a single mRNA. Many viruses utilize PRF to control o
Externí odkaz:
https://doaj.org/article/feb71a3b52da47038a2c0377e4d6d023
Autor:
Sofya A. Gaydukova, Mikhail A. Moldovan, Adriana Vallesi, Stephen M. Heaphy, John F. Atkins, Mikhail S. Gelfand, Pavel V. Baranov
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The triplet nature of the genetic code is considered a universal feature of known organisms. However, frequent stop codons at internal mRNA positions in Euplotes ciliates ultimately specify ribosomal frameshifting by one or two nucleotides depending
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27cb6f8090e8a738261756ca676784cc
https://doi.org/10.1073/pnas.2221683120
https://doi.org/10.1073/pnas.2221683120
Publikováno v:
Viruses, Vol 13, Iss 7, p 1251 (2021)
Many viruses, especially RNA viruses, utilize programmed ribosomal frameshifting and/or stop codon readthrough in their expression, and in the decoding of a few a UGA is dynamically redefined to specify selenocysteine. This recoding can effectively i
Externí odkaz:
https://doaj.org/article/b2b4e0e5c92c4c7dbc75d8752c6fbc4a
Autor:
Yousuf A. Khan, Gary Loughran, Anna-Lena Steckelberg, Katherine Brown, Stephen J. Kiniry, Hazel Stewart, Pavel V. Baranov, Jeffrey S. Kieft, Andrew E. Firth, John F. Atkins
Publikováno v:
Nature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11200417a01e04a71938b7f37b10a568
https://doi.org/10.1038/s41586-022-04627-y
https://doi.org/10.1038/s41586-022-04627-y
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192648 (2018)
The efficiency of start codon selection during ribosomal scanning in eukaryotic translation initiation is influenced by the context or flanking nucleotides surrounding the AUG codon. The levels of eukaryotic translation initiation factors 1 (eIF1) an
Externí odkaz:
https://doaj.org/article/ec785573cb3b4b33b8aea214646794ba