Zobrazeno 1 - 10
of 204
pro vyhledávání: '"John F, Andersen"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract Salivary complement inhibitors occur in many of the blood feeding arthropod species responsible for transmission of pathogens. During feeding, these inhibitors prevent the production of proinflammatory anaphylatoxins, which may interfere wit
Externí odkaz:
https://doaj.org/article/b90498de10f84314bc4a918c6c91e3cc
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract The salivary glands of hematophagous arthropods contain pharmacologically active molecules that interfere with host hemostasis and immune responses, favoring blood acquisition and pathogen transmission. Exploration of the salivary gland comp
Externí odkaz:
https://doaj.org/article/63992e6fd03e42efbf89cc440b693f22
Autor:
Anderson B. Guimaraes-Costa, John P. Shannon, Ingrid Waclawiak, Jullyanna Oliveira, Claudio Meneses, Waldione de Castro, Xi Wen, Joseph Brzostowski, Tiago D. Serafim, John F. Andersen, Heather D. Hickman, Shaden Kamhawi, Jesus G. Valenzuela, Fabiano Oliveira
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Immune mimicry has been shown in chemokine like moieties from bacteria and viruses. Here, the authors characterise a sand fly salivary protein that induces neutrophil chemotaxis and explore its impact in a model of parasitic infection.
Externí odkaz:
https://doaj.org/article/6c6f9032af8240ea805203e2fd59b3d5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15613 (2022)
Hard ticks feed for several days or weeks on their hosts and their saliva contains thousands of polypeptides belonging to dozens of families, as identified by salivary transcriptomes. Comparison of the coding sequences to protein databases helps to i
Externí odkaz:
https://doaj.org/article/01d792c0c29143bbb23bfa9be46f0f08
Publikováno v:
Biology, Vol 12, Iss 1, p 39 (2022)
Each time an insect bites a vertebrate host, skin and vascular injury caused by piercing triggers a series of responses including hemostasis, inflammation and immunity. In place, this set of redundant and interconnected responses would ultimately cau
Externí odkaz:
https://doaj.org/article/ce8f7f34345c43858c208ba8e36197a0
Autor:
Il Hwan Kim, Julio César Castillo, Azadeh Aryan, Inés Martin-Martin, Marcela Nouzova, Fernando G Noriega, Ana Beatriz F Barletta, Eric Calvo, Zachary N Adelman, José M C Ribeiro, John F Andersen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008288 (2020)
Insects rely on the innate immune system for defense against pathogens, some aspects of which are under hormonal control. Here we provide direct experimental evidence showing that the juvenile hormone-binding protein (mJHBP) of Aedes aegypti is requi
Externí odkaz:
https://doaj.org/article/fdfdbedddb8645bfb9b68a5acd84e301
Autor:
John F Andersen, Haotian Lei, Ethan C. Strayer, Tapan Kanai, Van Pham, Xiang-Zuo Pan, Patricia Hessab Alvarenga, Gloria F Gerber, Oluwatoyin A Asojo, Ivo M Francischetti, Robert A. Brodsky, Jesus G Valenzuela, Jose Ribeiro
Publikováno v:
Blood.
Inhibitors of complement and coagulation are present in the saliva of a variety of blood feeding arthropods that transmit parasitic and viral pathogens. Here we describe the structure and mechanism of action of the sand fly salivary protein lufaxin,
Autor:
Seong-Kyun, Lee, Leanne M, Low, John F, Andersen, Lee M, Yeoh, Paola Carolina, Valenzuela Leon, Damien R, Drew, Johannes S P, Doehl, Eric, Calvo, Louis H, Miller, James G, Beeson, Karthigayan, Gunalan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 120(1)
We used a transgenic parasite in which
Autor:
Antonio F. Mendes-Sousa, Vladimir Fazito do Vale, Naylene C. S. Silva, Anderson B. Guimaraes-Costa, Marcos H. Pereira, Mauricio R. V. Sant’Anna, Fabiano Oliveira, Shaden Kamhawi, José M. C. Ribeiro, John F. Andersen, Jesus G. Valenzuela, Ricardo N. Araujo
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inh
Externí odkaz:
https://doaj.org/article/62f679289333404d9f3a5edfbda1bda2
Autor:
Eric Calvo, Alvaro Molina-Cruz, John F. Andersen, Carolina Barillas-Mury, Adeline E. Williams, Thiago Luiz Alves e Silva, Lampouguin Yenkoidiok-Douti, Bianca M. Nagata, Gaspar E. Canepa, Martin J. Boulanger, Simardeep Nagyal
Publikováno v:
Proceedings of the National Academy of Sciences. 117:2597-2605
The surface protein Pfs47 allows Plasmodium falciparum parasites to survive and be transmitted by making them "undetectable" to the mosquito immune system. P. falciparum parasites express Pfs47 haplotypes compatible with their sympatric vectors, whil