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pro vyhledávání: '"John E.M. Midgley"'
Publikováno v:
Journal of Clinical & Translational Endocrinology, Vol 19, Iss , Pp - (2020)
Background: Subclinical hyperthyroidism/thyrotoxicosis originates from different causes and clinical conditions, sharing the laboratory constellation of a suppressed TSH in the presence of thyroid hormone concentrations within the reference range. Ai
Externí odkaz:
https://doaj.org/article/f3ac61de449a4a7aa604e85ca7f04325
Autor:
John E.M. Midgley
Publikováno v:
Clinical Biochemistry. 44:151-153
Objective To examine the merits of measuring free analytes by ultrafiltration using either diluted or undiluted serum. Results Confidence in the accuracy of measurements is affected both by problems identified in current systems using semipermeable m
Autor:
John E.M. Midgley
Publikováno v:
Clinical Chemistry. 47:1353-1363
Background: For the diagnosis of thyroid disease, measurement of “free hormone” is generally accepted as an appropriate measure. However, valid assays measuring the free fraction of thyroxine (FT4) ideally must perform without bias, despite large
Autor:
John E.M. Midgley, N D Christofides
Publikováno v:
Clinical Chemistry. 55:439-441
In the history of clinical immunoassay, even up to the present day, no group of tests has been subjected to more scrutiny and controversy than analog-type free-analyte assays (1)(2)(3)(4). Unfortunately, inappropriate design of many experiments has l
Autor:
N D Christofides, John E.M. Midgley
Publikováno v:
Clinical Chemistry. 55:2228-2229
We have read with interest recent reports of the measurement of free thyroxine and free triiodothyronine by ultrafiltration and tandem mass spectrometry (1)(2)(3)(4). There is, however, a fundamental flaw in these studies that we wish to bring to gen
Autor:
N D Christofides, John E.M. Midgley
Publikováno v:
American Journal of Obstetrics and Gynecology. 202:e6
Autor:
John E.M. Midgley
Publikováno v:
Clinical Chemistry. 53:1714-1714
I read with misgivings the recent communication by Fritz et al. (1) alleging that because under some circumstances an analog free thyroxine (FT4) immunoassay correlates total T4 and FT4 values, it does not measure FT4 but something akin to T4. I have