Zobrazeno 1 - 10
of 17
pro vyhledávání: '"John E.H. Tattersall"'
Autor:
Lindy Holden-Dye, A. Christopher Green, Vincent O'Connor, John E.H. Tattersall, Patricia G. Izquierdo
Publikováno v:
NeuroToxicology. 82:50-62
Inhibition of acetylcholinesterase by either organophosphates or carbamates causes anti-cholinesterase poisoning. This arises through a wide range of neurotoxic effects triggered by the overstimulation of the cholinergic receptors at synapses and neu
Publikováno v:
Toxicology Mechanisms and Methods. 30:703-710
Therapeutic efficacy of antidotal treatment of acute poisoning by nerve agents is generally assessed by the evaluation of LD50 values of nerve agents over 24 h following poisoning without or with a...
Autor:
A. Christopher Green, Helen Rice, Samuel J. Gore, John E.H. Tattersall, Mike Bird, Charlotte Whitmore, Christopher D. Lindsay, Christopher M. Timperley
Publikováno v:
Toxicology Letters. 325:67-76
Racemic 3-quinuclidinyl-α-methoxydiphenylacetate (MB266) was synthesised. Its activity at muscarinic acetylcholine receptors (mAChRs), and muscle and neuronal nicotinic acetylcholine receptors (nAChRs), was compared to that of atropine and racemic 3
Autor:
A. Christopher Green, Fernando Calahorro, Vincent O'Connor, Patricia G. Izquierdo, John E.H. Tattersall, Thibana Thisainathan, James H. Atkins, Lindy Holden-Dye, Christian J. Lewis, Johanna Haszczyn
Publikováno v:
The Journal of Biological Chemistry
Complex biological functions within organisms are frequently orchestrated by systemic communication between tissues. In the model organism Caenorhabditis elegans, the pharyngeal and body wall neuromuscular junctions are two discrete structures that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6d265e083609634265400ec051cc6b
https://eprints.soton.ac.uk/455897/
https://eprints.soton.ac.uk/455897/
Autor:
Patricia G. Izquierdo, Claude L. Charvet, Cedric Neveu, A. Christopher Green, John E.H. Tattersall, Lindy Holden-Dye, Vincent O’Connor
Plasticity is a reactive mechanism that allows the adaptation of organisms to changing environmental cues. The exploitation of this physiological process has a clear benefit to promote the recovery from a wide range of neurological disorders. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::523fdbcd9633d8edde4f6a07c0993634
https://doi.org/10.1101/2021.05.01.442241
https://doi.org/10.1101/2021.05.01.442241
Autor:
Patricia G. Izquierdo, Thibana Thisainathan, James H. Atkins, Christian J. Lewis, John E.H. Tattersall, A. Christopher Green, Lindy Holden-Dye, Vincent O’Connor
Complex biological functions within organisms are frequently orchestrated by systemic communication between tissues. In the model organismC. elegans, the pharyngeal and body wall neuromuscular junctions are two discrete structures that control feedin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::059c1be3c915211271bdc2e7568085f4
https://doi.org/10.1101/2021.02.12.430967
https://doi.org/10.1101/2021.02.12.430967
Autor:
John E.H. Tattersall, Max Epstein, Christopher M. Timperley, A. Christopher Green, Isabel Bermudez, Karan Bali, Philip C. Biggin, Thomas J. Piggot, Mike Bird
Publikováno v:
Toxicology letters. 340
Organophosphorus nerve agents (NAs) are the most lethal chemical warfare agents and have been used by state and non-state actors since their discovery in the 1930s. They covalently modify acetylcholinesterase, preventing the breakdown of acetylcholin
Autor:
Lindy Holden-Dye, A. Christopher Green, John E.H. Tattersall, Patricia G. Izquierdo, Vincent O'Connor
Inhibition of acetylcholinesterase by either organophosphates or carbamates causes anti-cholinesterase poisoning. This arises through a wide range of neurotoxic effects triggered by the overstimulation of the cholinergic receptors at synapses and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e41a33a583144113f6506471cd4f29e7
https://doi.org/10.1101/2020.06.03.131490
https://doi.org/10.1101/2020.06.03.131490
Autor:
Christopher M. Timperley, A. Christopher Green, Jiri Kassa, John E.H. Tattersall, Rebecca L. Williams, Mike Bird
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 122:429-435
The influence of three newly-developed bispyridinium antinicotinic compounds (the non-oximes MB408, MB442 and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with an oxime) of acute poisoning by the organ
Autor:
Helen Rice, Sarah J. Fairhall, John E.H. Tattersall, Cerys J. Docx, Luke Whiley, Daniel P. Flint, Christopher M. Timperley, Sarah J.C. Poole, A. Christopher Green, Michael Bird, Matthew E. Price
Publikováno v:
Toxicology Letters. 244:154-160
Current organophosphorus nerve agent medical countermeasures do not directly address the nicotinic effects of poisoning. A series of antinicotinic bispyridinium compounds has been synthesized in our laboratory and screened in vitro. Their actions can