Zobrazeno 1 - 10
of 152
pro vyhledávání: '"John E. Wilkinson"'
Autor:
Dongyan Song, Jose M. Adrover, Christy Felice, Lisa N. Christensen, Xue-Yan He, Joseph R. Merrill, John E. Wilkinson, Tobias Janowitz, Scott K. Lyons, Mikala Egeblad, Nicholas K. Tonks
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
Acute lung injury (ALI) can cause acute respiratory distress syndrome (ARDS), a lethal condition with limited treatment options and currently a common global cause of death due to COVID-19. ARDS secondary to transfusion-related ALI (TRALI) has been r
Externí odkaz:
https://doaj.org/article/9a755f6522ea47d481f935c94edc60d1
Autor:
Mary J. Feigman, Matthew A. Moss, Chen Chen, Samantha L. Cyrill, Michael F. Ciccone, Marygrace C. Trousdell, Shih-Ting Yang, Wesley D. Frey, John E. Wilkinson, Camila O. dos Santos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mammary epithelial cells are epigenetically modified during pregnancy, these changes can influence the pre-disposition to cancer. Here, the authors examine the epigenetic landscape of mammary epithelial cells pre and post pregnancy and identify chang
Externí odkaz:
https://doaj.org/article/be6daa3b32964ca8879edb8c33935d36
Autor:
Julian Taranda, Grinu Mathew, Kaitlin Watrud, Nour El-Amine, Matthew F. Lee, Corey Elowsky, Anastasiia Bludova, Sintia Escobar Avelar, Dawid G. Nowak, Tse-Luen Wee, John E. Wilkinson, Lloyd C. Trotman, Pavel Osten
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110027- (2021)
Summary: Early steps of cancer initiation and metastasis, while critical for understanding disease mechanisms, are difficult to visualize and study. Here, we describe an approach to study the processes of initiation, progression, and metastasis of pr
Externí odkaz:
https://doaj.org/article/89cbad6d853b4185be074d68ba31ccb4
Autor:
Jonathan J. Herrera, Sean Louzon, Kaitlyn Pifer, Danielle Leander, Gennifer E. Merrihew, Jea H. Park, Kate Szczesniak, Jeremy Whitson, John E. Wilkinson, Oliver Fiehn, Michael J. MacCoss, Sharlene M. Day, Richard A. Miller, Michael Garratt
Publikováno v:
JCI Insight, Vol 5, Iss 21 (2020)
With an expanding aging population burdened with comorbidities, there is considerable interest in treatments that optimize health in later life. Acarbose (ACA), a drug used clinically to treat type 2 diabetes mellitus (T2DM), can extend mouse life sp
Externí odkaz:
https://doaj.org/article/ca141dd254714c9a82f00d412aa7bfea
Autor:
Teng Han, Emma M. Schatoff, Charles Murphy, Maria Paz Zafra, John E. Wilkinson, Olivier Elemento, Lukas E. Dow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Recent evidence suggests thatEIF3E–RSPO2 and PTPRK–RSPO3gene fusions promote colorectal cancer. Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome rearrangements result in intestinal tumours ext
Externí odkaz:
https://doaj.org/article/1723273cb2e14f359f103ef93504189d
Autor:
Jessica E. Bolden, Nilgun Tasdemir, Lukas E. Dow, Johan H. van Es, John E. Wilkinson, Zhen Zhao, Hans Clevers, Scott W. Lowe
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1919-1929 (2014)
BET family proteins are novel therapeutic targets for cancer and inflammation and represent the first chromatin readers against which small-molecule inhibitors have been developed. First-generation BET inhibitors have shown therapeutic efficacy in pr
Externí odkaz:
https://doaj.org/article/b64a8a75a4e34fd083c4ffef2869b78e
Autor:
Anthony Mazurek, Youngkyu Park, Cornelius Miething, John E. Wilkinson, Jesse Gillis, Scott W. Lowe, Christopher R. Vakoc, Bruce Stillman
Publikováno v:
Cell Reports, Vol 7, Iss 6, Pp 1887-1899 (2014)
Acute myeloid leukemia (AML) therapy involves compounds that are cytotoxic to both normal and cancer cells, and relapsed AML is resistant to subsequent chemotherapy. Thus, agents are needed that selectively kill AML cells with minimal toxicity. Here,
Externí odkaz:
https://doaj.org/article/acde7eed177e4d9d99d495f30b082d15
Autor:
Timothy J. Bauler, Nobuhiro Kamiya, Philip E. Lapinski, Eric Langewisch, Yuji Mishina, John E. Wilkinson, Gen-Sheng Feng, Philip D. King
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 2, Pp 228-239 (2011)
SUMMARY SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome
Externí odkaz:
https://doaj.org/article/b478d071549b45198fb0ece0f4744796
Autor:
Stefan Taube, Abimbola O. Kolawole, Marina Höhne, John E. Wilkinson, Scott A. Handley, Jeffrey W. Perry, Larissa B. Thackray, Ramesh Akkina, Christiane E. Wobus
Publikováno v:
mBio, Vol 4, Iss 4 (2013)
ABSTRACT Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since “humanized” mice have been successfully used to st
Externí odkaz:
https://doaj.org/article/d7a2d9876efd4f31931c45525e64de71
Autor:
Haiwei Mou, Onur Eskiocak, Kadir A. Özler, Megan Gorman, Junjiayu Yue, Ying Jin, Zhikai Wang, Ya Gao, Tobias Janowitz, Hannah V. Meyer, Tianxiong Yu, John E Wilkinson, Alper Kucukural, Deniz M. Ozata, Semir Beyaz
Publikováno v:
The Journal of Pathology. 259:415-427