Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John E. Trombley"'
Autor:
Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108062- (2020)
Summary: Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key
Externí odkaz:
https://doaj.org/article/b804d5f73aa147ecb872b34cc558199e
Publikováno v:
Diabetes. 70
Insulin secretion from pancreatic β-cells occurs in a biphasic manner. The loss of the early phase of insulin secretion, which occurs due to the inability of insulin granules to fuse with the plasma membrane (PM) via the formation of the SNARE compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45b4c4fd67872b42d277b7fea0bd1a30
https://doi.org/10.2337/db21-125-or
https://doi.org/10.2337/db21-125-or
Publikováno v:
Diabetes. 70
Insulin secretion from beta-cells of pancreatic islets is essential for regulating whole-blood glucose homeostasis. Impaired insulin secretion is an early event in the development of obesity-linked type 2 diabetes (T2D). However, underlying molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64893df9ba045645bfa60806ce5ac013
https://doi.org/10.2337/db21-1255-p
https://doi.org/10.2337/db21-1255-p
Publikováno v:
Diabetes. 70
Secreted proteins are important metabolic regulators in the healthy and disease states. Using network biology approaches, our laboratory identified that complement-1q like-3 (C1ql3) secreted protein has a role in affecting pancreatic islet function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f7af125cdda8145cf7280a10afaf9b
https://doi.org/10.2337/db21-1251-p
https://doi.org/10.2337/db21-1251-p
Autor:
Larry E. Bowen, Katie eRivers, John E. Trombley, Jeremy A. Boydstion, J. Kyle Bohannon, Shixiong X. Li, Maryna C. Eichelberger
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Influenza continues to cause widespread disease and death during winter months. In preclinical studies to evaluate the potential efficacy of drugs and vaccines, influenza challenge virus is usually instilled into the noses of animals in the form of l
Externí odkaz:
https://doaj.org/article/e3c1b179cd104a779a8ff8d15356eb1c
Autor:
John E. Trombley, Pitchaimani Kandasamy, James Mitchell, Kevin S. Harrod, Yoji Nagashima, Jennifer L. Tipper, Mari Numata, Hong Wei Chu, Dennis R. Voelker, Jeffrey D. Brand
Publikováno v:
J Biol Chem
The influenza A (H1N1)pdm09 outbreak in 2009 exemplified the problems accompanying the emergence of novel influenza A virus (IAV) strains and their unanticipated virulence in populations with no pre-existing immunity. Neuraminidase inhibitors (NAIs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed719866b8e816a7017bfe68a929e90
https://pubmed.ncbi.nlm.nih.gov/31882535
https://pubmed.ncbi.nlm.nih.gov/31882535
Autor:
Niroop Kaza, Vivian Y. Lin, Denise Stanford, Shah S. Hussain, Emily Falk Libby, Harrison Kim, Monica Borgonovi, Katja Conrath, Venkateshwar Mutyam, Stephen A. Byzek, Li Ping Tang, John E. Trombley, Lawrence Rasmussen, Trenton Schoeb, Hui Min Leung, Guillermo J. Tearney, S. Vamsee Raju, Steven M. Rowe
Publikováno v:
Eur Respir J
RationaleThe majority of chronic obstructive pulmonary disease (COPD) patients have chronic bronchitis, for which specific therapies are unavailable. Acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction is observed in chron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b367ca79d9cb487c3dcf714048e05599
https://doi.org/10.1183/13993003.01581-2021
https://doi.org/10.1183/13993003.01581-2021
Autor:
Amit R. Ashtekar, Jennifer L. Tipper, John E. Trombley, Jeffrey D. Brand, A. Timothy Adewale, Ren-Jay Shei, Ahmed Lazrak, Kevin S. Harrod, Zhihong Yu, Steven M. Rowe, Sadis Matalon
Publikováno v:
JCI Insight. 3
Severe influenza (IAV) infection can develop into bronchopneumonia and edema, leading to acquired respiratory distress syndrome (ARDS) and pathophysiology. Underlying causes for pulmonary edema and aberrant fluid regulation largely remain unknown, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c70067aa65a0bd0016a110ffcb4c3b
https://doi.org/10.1172/jci.insight.123467
https://doi.org/10.1172/jci.insight.123467
Autor:
George M. Solomon, Steven M. Rowe, John E. Trombley, Cecilia W. Lo, George C. Gabriel, Kristi Lemke, Brett Turner, Susan E. Birket, Nikolai Klena, Kengyeh K. Chu, Richard Francis, Guillermo J. Tearney
Publikováno v:
JCI Insight. 2
Ciliary motion defects cause defective mucociliary transport (MCT) in primary ciliary dyskinesia (PCD). Current diagnostic tests do not assess how MCT is affected by perturbation of ciliary motion. In this study, we sought to use micro-optical cohere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166f0e48fe1c400b7db970e9e3648ecc
https://doi.org/10.1172/jci.insight.91702
https://doi.org/10.1172/jci.insight.91702
Autor:
Hyunki Kim, Kurt R. Zinn, Sharon Samuel, J. Michael Wells, Patricia L. Jackson, Lawrence Rasmussen, Emily Falk Libby, Erik D. Dohm, Lindy Winter, S. Vamsee Raju, John E. Trombley, Li Ping Tang, J. Edwin Blalock, Steven M. Rowe, Mark T. Dransfield, Stephen A. Byzek, Trenton R. Schoeb
Publikováno v:
JCI insight. 1(15)
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the US. The majority of COPD patients have symptoms of chronic bronchitis, which lacks specific therapies. A major impediment to therapeutic development has been the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306c1f57cf1ccb25343b46843c898ee7
https://pubmed.ncbi.nlm.nih.gov/27699245
https://pubmed.ncbi.nlm.nih.gov/27699245