Zobrazeno 1 - 10
of 23
pro vyhledávání: '"John E. Schurig"'
Publikováno v:
Journal of Medicinal Chemistry. 33:2184-2188
The antitumor and DNA-binding properties of a group of oligomeric platinum(II) and platinum(IV) complexes are described. The compounds, having the stoichiometry [cis-Pt II (X) 2 (μ-OH] 2 (NO 3 ) 2 , where X is NH 3 , NH 2 CH 2 CH 3 , and NH 2 CH(CH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31aebc8f2673a44e294c54ccdc1f6f0a
https://doi.org/10.1021/jm00170a022
https://doi.org/10.1021/jm00170a022
Publikováno v:
The Journal of Antibiotics. 43:125-127
Although rebeccamycin exhibits significant in vivo antitumor activity against P388 leukemia and B16 melanoma, its limited solubility in aqueous media posed some problems in further evaluation. In order to find more water-soluble analogues wa have car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582a43645f213661b1c1f6582d705961
https://doi.org/10.7164/antibiotics.43.125
https://doi.org/10.7164/antibiotics.43.125
Autor:
Dale A. Stringfellow, Hideo Kamei, John E. Schurig, Yuji Nishiyama, William C. Rose, William T. Bradner
Publikováno v:
Investigational new drugs. 8(1)
BMY-28175 is a novel antitumor antibiotic produced in fermentation by Actinomadura verrucosospora. The cytotoxic effects of BMY-28175 were determined using murine and human tumor cell lines in vitro. Following 72 hour exposure, the drug had IC50 valu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276f5334f9c3a64bfafc6d3c923650df
https://pubmed.ncbi.nlm.nih.gov/2345072
https://pubmed.ncbi.nlm.nih.gov/2345072
Publikováno v:
Investigational new drugs. 8
BMY-25067, N-7[2-(4-nitrophenyldithio)-ethyl] mitomycin C was selected from a number of disulfide derivatives of the highly active compound RR150, N-7(thioethyl) mitomycin C for further study. BMY-25067 had tumor inhibitory effects equivalent to mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3166c8d2c8b82ccd25a49275d722ae0
https://pubmed.ncbi.nlm.nih.gov/2380013
https://pubmed.ncbi.nlm.nih.gov/2380013
Publikováno v:
International Archives of Allergy and Immunology. 67:101-108
BL-5255 exhibited potent activity in several models of antigen-induced immediate hypersensitivity reactions in rats and guinea pigs. The compound was effective whether administered by oral or parenteral routes and in passively and actively sensitized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de2a632f10d2e8a4911124dc692d97d4
https://doi.org/10.1159/000232998
https://doi.org/10.1159/000232998
Publikováno v:
Investigational New Drugs. 7:173-178
BMY-28090 is a novel actinomycete fermentation derived antitumor agent. The cytotoxic effect of BMY-28090 was evaluated in two murine and eight human tumor cell lines in vitro. Following 72-hour exposures, BMY-28090 was cytotoxic for all of these cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487453a78764ac2905a08692996e302c
https://doi.org/10.1007/bf00170854
https://doi.org/10.1007/bf00170854
Publikováno v:
Journal of Medicinal Chemistry. 30:716-719
The synthesis and characterization of a group of platinum(IV) compounds containing the various isomeric forms of 1,2-diaminocyclohexane (DACH) are described. Antitumor tests with the new complexes, as well as with other platinum(II) compounds contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dec0f6c4f0b8610d29c3c8c633e9c50
https://doi.org/10.1021/jm00387a023
https://doi.org/10.1021/jm00387a023
Autor:
John E. Schurig, William C. Rose
Publikováno v:
Cancer Treatment Reviews. 12:1-19
Carboplatin, an analog of the antitumor drug Platinol, was selected for clinical evaluation on the basis of its experimental antitumor and toxicologic profile in animal models. Described in this review is a detailed summary of selected preclinical da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96349f0d6b140b1dbea42712d8f9f2a1
https://doi.org/10.1016/0305-7372(85)90014-3
https://doi.org/10.1016/0305-7372(85)90014-3
Autor:
William T. Bradner, John E. Schurig
Publikováno v:
Cancer Treatment Reviews. 8:93-102
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b0bc2035de4af27e7dee1c4c5caa6
https://doi.org/10.1016/s0305-7372(81)80029-1
https://doi.org/10.1016/s0305-7372(81)80029-1
Autor:
William C. Rose, Robert S. Hirth, William T. Bradner, John E. Schurig, Abraham Schlein, J B Huftalen, Alexander P. Florczyk
Publikováno v:
Cancer Chemotherapy and Pharmacology. 13:164-170
Tallysomycin S10b (TLM S10b), a structural analog of bleomycin (BLM), was evaluated and compared with BLM for antitumor activity in several murine tumor systems and for toxic effects in mice and rats. Neither TLM S10b nor BLM was effective against IP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300ad78ea0ba89f7031ce46cbe9366ff
https://doi.org/10.1007/bf00269022
https://doi.org/10.1007/bf00269022