Zobrazeno 1 - 10
of 47
pro vyhledávání: '"John E. Pak"'
Autor:
Scott B. Biering, Francielle Tramontini Gomes de Sousa, Laurentia V. Tjang, Felix Pahmeier, Chi Zhu, Richard Ruan, Sophie F. Blanc, Trishna S. Patel, Caroline M. Worthington, Dustin R. Glasner, Bryan Castillo-Rojas, Venice Servellita, Nicholas T. N. Lo, Marcus P. Wong, Colin M. Warnes, Daniel R. Sandoval, Thomas Mandel Clausen, Yale A. Santos, Douglas M. Fox, Victoria Ortega, Anders M. Näär, Ralph S. Baric, Sarah A. Stanley, Hector C. Aguilar, Jeffrey D. Esko, Charles Y. Chiu, John E. Pak, P. Robert Beatty, Eva Harris
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction, however, the molecular pathways resulting in endothelial barrier dysfunction and vascular leakage are only sparsely understood. Here, Biering et al. show that SARS-CoV
Externí odkaz:
https://doaj.org/article/4d267ba8c95f4d14abd51985e3d493fd
Autor:
Isobel Routledge, Adrienne Epstein, Saki Takahashi, Owen Janson, Jill Hakim, Elias Duarte, Keirstinne Turcios, Joanna Vinden, Kirk Sujishi, Jesus Rangel, Marcelina Coh, Lee Besana, Wai-Kit Ho, Ching-Ying Oon, Chui Mei Ong, Cassandra Yun, Kara Lynch, Alan H. B. Wu, Wesley Wu, William Karlon, Edward Thornborrow, Michael J. Peluso, Timothy J. Henrich, John E. Pak, Jessica Briggs, Bryan Greenhouse, Isabel Rodriguez-Barraquer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Population-based surveys are the gold standard for estimating seroprevalence but are expensive and often only capture a small geographic area or window of time. This study describes a new platform, SCALE-IT, for serosurveillance based on algorithmic
Externí odkaz:
https://doaj.org/article/2c73ad75f25940cfa9325487cf55c8e4
Autor:
Janie R. Byrum, Eric Waltari, Owen Janson, Syuan-Ming Guo, Jenny Folkesson, Bryant B. Chhun, Joanna Vinden, Ivan E. Ivanov, Marcus L. Forst, Hongquan Li, Adam G. Larson, Lena Blackmon, Ziwen Liu, Wesley Wu, Vida Ahyong, Cristina M. Tato, Krista M. McCutcheon, Rebecca Hoh, J. Daniel Kelly, Jeffrey N. Martin, Michael J. Peluso, Timothy J. Henrich, Steven G. Deeks, Manu Prakash, Bryan Greenhouse, Shalin B. Mehta, John E. Pak
Publikováno v:
Pathogens, Vol 12, Iss 5, p 671 (2023)
A multiplexed enzyme-linked immunosorbent assay (ELISA) that simultaneously measures antibody binding to multiple antigens can extend the impact of serosurveillance studies, particularly if the assay approaches the simplicity, robustness, and accurac
Externí odkaz:
https://doaj.org/article/d7bd915e61c04e7fb73fcb2422aa49e0
Autor:
Abigail E. Powell, Kaiming Zhang, Mrinmoy Sanyal, Shaogeng Tang, Payton A. Weidenbacher, Shanshan Li, Tho D. Pham, John E. Pak, Wah Chiu, Peter S. Kim
Publikováno v:
ACS Central Science, Vol 7, Iss 1, Pp 183-199 (2021)
Externí odkaz:
https://doaj.org/article/cd75c0c545ba4c0b85ff1f88d2d104d3
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010052 (2022)
The sequencing of antibody repertoires of B-cells at increasing coverage and depth has led to the identification of vast numbers of immunoglobulin heavy and light chains. However, the size and complexity of these Adaptive Immune Receptor Repertoire s
Externí odkaz:
https://doaj.org/article/e3763f3c7aec427981046b60a21567e4
Autor:
Natasha D Durham, Aditi Agrawal, Eric Waltari, Derek Croote, Fabio Zanini, Mallorie Fouch, Edgar Davidson, Olivia Smith, Esteban Carabajal, John E Pak, Benjamin J Doranz, Makeda Robinson, Ana M Sanz, Ludwig L Albornoz, Fernando Rosso, Shirit Einav, Stephen R Quake, Krista M McCutcheon, Leslie Goo
Publikováno v:
eLife, Vol 8 (2019)
Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4) that are spreading into new territories is an important goal of vaccine design. To define bNAb targets, we characterized 28 antibodies belonging to ex
Externí odkaz:
https://doaj.org/article/ccae0927312e48c899d2a400f15ffaf6
Autor:
Brian L. Hie, Varun R. Shanker, Duo Xu, Theodora U. J. Bruun, Payton A. Weidenbacher, Shaogeng Tang, Wesley Wu, John E. Pak, Peter S. Kim
Publikováno v:
Nature Biotechnology.
Natural evolution must explore a vast landscape of possible sequences for desirable yet rare mutations, suggesting that learning from natural evolutionary strategies could guide artificial evolution. Here we report that general protein language model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fb6b62a9f8f2d6ca47ab61260b6c6d
https://doi.org/10.1038/s41587-023-01763-2
https://doi.org/10.1038/s41587-023-01763-2
Autor:
Alan H.B. Wu, Wesley Wu, Isobel Routledge, Saki Takahashi, Chui Mei Ong, Edward Thornborrow, Lee Besana, Jessica Briggs, Michael J. Peluso, Kirk Sujishi, Timothy J. Henrich, Ching Ying Oon, Keirstinne Turcios, Cassandra Yun, Marcelina Coh, Wai Kit Ho, Joanna Vinden, Owen Janson, Elias Duarte, Jill Hakim, Kara L. Lynch, Isabel Rodriguez-Barraquer, Adrienne Epstein, John E. Pak, William J. Karlon, Jesus Rangel, Bryan Greenhouse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
Serosurveillance provides a unique opportunity to quantify the proportion of the population that has been exposed to pathogens. Here, we developed and piloted Serosurveillance for Continuous, ActionabLe Epidemiologic Intelligence of Transmission (SCA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2930edb1a467a7475c3da3872460df0d
https://doaj.org/article/2c73ad75f25940cfa9325487cf55c8e4
https://doaj.org/article/2c73ad75f25940cfa9325487cf55c8e4
Autor:
John E. Pak, Sanghwa Jeong, Hung Yu Sun, Lili Kuo, Markita P. Landry, Nicole Navarro, Francis Ledesma, Yung Chun Chuang, Darwin Yang, Rebecca L. Pinals, Yu Wei Cheng
Publikováno v:
medRxiv
To effectively track and eliminate COVID-19, it is critical to develop tools for rapid and accessible diagnosis of actively infected individuals. Here, we introduce a single-walled carbon nanotube (SWCNT)-based optical sensing approach towards these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f60854628c9f4185b01f790b325e37b
https://doi.org/10.1021/acs.nanolett.1c00118
https://doi.org/10.1021/acs.nanolett.1c00118
Autor:
Payton A-B, Weidenbacher, Eric, Waltari, Izumi, de Los Rios Kobara, Benjamin N, Bell, Mary Kate, Morris, Ya-Chen, Cheng, Carl, Hanson, John E, Pak, Peter S, Kim
Publikováno v:
Nature chemical biology. 18(11)
Omicron and its subvariants have rendered most authorized monoclonal antibody-based treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ineffective, highlighting the need for biologics capable of overcoming SARS-CoV-2 evolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1b84a40a365f86121a0d2b6ff796dc0
https://pubmed.ncbi.nlm.nih.gov/36076082
https://pubmed.ncbi.nlm.nih.gov/36076082