Zobrazeno 1 - 10
of 53
pro vyhledávání: '"John E. Oakes"'
Publikováno v:
Journal of Leukocyte Biology. 83:401-408
IL-17 has been associated with selected inflammatory and autoimmune diseases. We characterized the expression of this proinflammatory cytokine following HSV-1 corneal infection and investigated whether IL-17R signaling modulated the host response to
Publikováno v:
Ocular Immunology and Inflammation. 15:295-302
The purpose of this study was to characterize the synthesis of alpha-chemokines IP-10, MIG, and I-TAC by human corneal epithelial cells (HCE) following exposure to proinflammatory mediators. Supernatants were collected from HCE cultures stimulated wi
Autor:
Sara Molesworth-Kenyon, A. Mates, Rong Yin, Robert N. Lausch, John E. Oakes, Robert M. Strieter
Publikováno v:
Virology. 333:1-9
Sensitized CD4+ T cells play an essential role in delayed type hypersensitivity (DTH) elicited by HSV-1 antigen. As activated CD4+ T cells express CXCR3, we investigated whether this chemokine receptor was involved in their recruitment. Antibody bloc
Publikováno v:
Journal of Leukocyte Biology. 77:552-559
Analogous to CD4+ T cells, neutrophils are essential participants in delayed-type hypersensitivity (DTH) to Herpes simplex virus type 1 antigen. However, what role they play in this cellular immune response is unclear. The recent recognition that neu
Autor:
Robert N. Lausch, John E. Oakes, Allison Troupe, Sara J Molesworth-Kenyon, Ashley Milam, Amanda Rockette
Publikováno v:
Current eye research. 40(8)
To investigate the production of monokine induced by gamma-interferon (MIG) during a primary Herpes simplex virus type 1 (HSV-1) infection of the cornea. We hypothesize that multiple CXCR3 ligands are involved in T cell recruitment during HSV-1 corne
Publikováno v:
Experimental Eye Research. 73:403-407
Publikováno v:
Journal of Leukocyte Biology. 69:149-157
We investigated whether IL-10 produced endogenously would influence the development of HSV-1-induced acute corneal disease. Murine corneal epithelial cells and fibroblasts cultured in vitro expressed IL-10 mRNA and protein constitutively and also IL-
Publikováno v:
Journal of Leukocyte Biology. 63:486-492
Herpes simplex virus type 1 (HSV-1) infection of the murine cornea results in a tissue-destructive inflammatory response. In this study we show that virus infection induces the synthesis of macrophage inflammatory protein-2 (MIP-2), MIP-1α, and mono
Publikováno v:
Virology. 244(1):74-78
Nanogram amounts of the proinflammatory cytokine interleukin-1alpha (IL-1alpha) were detected in uninfected cultures of human corneal epithelial cells (HCEC). Although HSV-1 replicated >10(4)-fold in these cells and caused extensive cytopathic effect
Publikováno v:
Journal of Virology. 70:1277-1281
Herpes simplex virus type 1 (HSV-1) infection on the murine cornea induces an intense inflammatory response which can lead to blindness. This disease, known as herpes stromal keratitis, can be prevented by the timely passive transfer of monoclonal an