Zobrazeno 1 - 10
of 165
pro vyhledávání: '"John E. Mcdonough"'
Autor:
Tobias Heigl, Janne Kaes, Celine Aelbrecht, Jef Serré, Yoshito Yamada, Vincent Geudens, Anke Van Herck, Arno Vanstapel, Annelore Sacreas, Sofie Ordies, Anna Frick, Berta Saez Gimenez, Jan Van Slambrouck, Hanne Beeckmans, Nilüfer A. Acet Oztürk, Michaela Orlitova, Annemie Vaneylen, Sandra Claes, Dominique Schols, Greetje Vande Velde, Jonas Schupp, Naftali Kaminski, Markus Boesch, Hannelie Korf, Schalk van der Merwe, Lieven Dupont, Jeroen Vanoirbeek, Laurent Godinas, Dirk E. Van Raemdonck, Wim Janssens, Ghislaine Gayan-Ramirez, Laurens J. Ceulemans, John E. McDonough, Erik K. Verbeken, Robin Vos, Bart M. Vanaudenaerde
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChronic rejection is a major complication post-transplantation. Within lung transplantation, chronic rejection was considered as airway centred. Chronic Lung Allograft Dysfunction (CLAD), defined to cover all late chronic complications, m
Externí odkaz:
https://doaj.org/article/523cb3938ed14de6b83dbb256d799395
Autor:
Pieterjan Kerckhof, Gene P.L. Ambrocio, Hanne Beeckmans, Janne Kaes, Vincent Geudens, Saskia Bos, Lynn Willems, Astrid Vermaut, Marie Vermant, Tinne Goos, Charlotte De Fays, Lucia Aversa, Yousry Mohamady, Arno Vanstapel, Michaela Orlitová, Jan Van Slambrouck, Xin Jin, Vimi Varghese, Iván Josipovic, Matthieu N. Boone, Lieven J. Dupont, Birgit Weynand, Adriana Dubbeldam, Dirk E. Van Raemdonck, Laurens J. Ceulemans, Ghislaine Gayan-Ramirez, Laurens J. De Sadeleer, John E. McDonough, Bart M. Vanaudenaerde, Robin Vos
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105030- (2024)
Summary: Background: Chronic lung allograft dysfunction (CLAD) encompasses three main phenotypes: bronchiolitis obliterans syndrome (BOS), restrictive allograft syndrome (RAS) and a Mixed phenotype combining both pathologies. How the airway structure
Externí odkaz:
https://doaj.org/article/74c39f4f6a8f4b25a9a6b0237861612e
iDESC: identifying differential expression in single-cell RNA sequencing data with multiple subjects
Autor:
Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang, Xiting Yan
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Single-cell RNA sequencing (scRNA-seq) technology has enabled assessment of transcriptome-wide changes at single-cell resolution. Due to the heterogeneity in environmental exposure and genetic background across subjects, subject e
Externí odkaz:
https://doaj.org/article/98bb000233a34cca8225fba23b3cf131
Autor:
Charlotte de Fays, Vincent Geudens, Iwein Gyselinck, Pieterjan Kerckhof, Astrid Vermaut, Tinne Goos, Marie Vermant, Hanne Beeckmans, Janne Kaes, Jan Van Slambrouck, Yousry Mohamady, Lynn Willems, Lucia Aversa, Emanuela E. Cortesi, Charlotte Hooft, Gitte Aerts, Celine Aelbrecht, Stephanie Everaerts, John E. McDonough, Laurens J. De Sadeleer, Sophie Gohy, Jerome Ambroise, Wim Janssens, Laurens J. Ceulemans, Dirk Van Raemdonck, Robin Vos, Tillie L. Hackett, James C. Hogg, Naftali Kaminski, Ghislaine Gayan-Ramirez, Charles Pilette, Bart M. Vanaudenaerde
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
RationaleCOPD is characterized by chronic airway inflammation, small airways changes, with disappearance and obstruction, and also distal/alveolar destruction (emphysema). The chronology by which these three features evolve with altered mucosal immun
Externí odkaz:
https://doaj.org/article/101061ce7f3f4ec7b9919abd90367f9a
Autor:
Yunqing Liu, Jiayi Zhao, Taylor S. Adams, Ningya Wang, Jonas C. Schupp, Weimiao Wu, John E. McDonough, Geoffrey L. Chupp, Naftali Kaminski, Zuoheng Wang, Xiting Yan
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/3da99a1637a2445db9e02f0e0409547c
Autor:
Farida Ahangari, Nathan L. Price, Shipra Malik, Maurizio Chioccioli, Thomas Bärnthaler, Taylor S. Adams, Jooyoung Kim, Sai Pallavi Pradeep, Shuizi Ding, Carlos Cosmos Jr., Kadi-Ann S. Rose, John E. McDonough, Nachelle R. Aurelien, Gabriel Ibarra, Norihito Omote, Jonas C. Schupp, Giuseppe DeIuliis, Julian A. Villalba Nunez, Lokesh Sharma, Changwan Ryu, Charles S. Dela Cruz, Xinran Liu, Antje Prasse, Ivan Rosas, Raman Bahal, Carlos Fernández-Hernando, Naftali Kaminski
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent findings have shown a marked metabolic reprogramming associated with changes in mitochondrial homeostasis and autophagy during pulmonary fibrosis. The microRNA-
Externí odkaz:
https://doaj.org/article/8e344ceda710493a941fd128cb400f5b
Autor:
Maor Sauler, John E. McDonough, Taylor S. Adams, Neeharika Kothapalli, Thomas Barnthaler, Rhiannon B. Werder, Jonas C. Schupp, Jessica Nouws, Matthew J. Robertson, Cristian Coarfa, Tao Yang, Maurizio Chioccioli, Norihito Omote, Carlos Cosme, Sergio Poli, Ehab A. Ayaub, Sarah G. Chu, Klaus H. Jensen, Jose L. Gomez, Clemente J. Britto, Micha Sam B. Raredon, Laura E. Niklason, Andrew A. Wilson, Pascal N. Timshel, Naftali Kaminski, Ivan O. Rosas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Chronic obstructive pulmonary disease is a leading cause of death worldwide, while our understanding of cell-specific mechanisms underlying its pathobiology remains incomplete. Here the authors perform scRNA-seq of human lung tissue to identify trans
Externí odkaz:
https://doaj.org/article/3579d31a63b3485fb4b3e87914915625
Autor:
Feng Xu, Naoya Tanabe, Dragos M. Vasilescu, John E. McDonough, Harvey O. Coxson, Kohei Ikezoe, Daisuke Kinose, Kevin W. Ng, Stijn E. Verleden, Wim A. Wuyts, Bart M. Vanaudenaerde, Johny Verschakelen, Joel D. Cooper, Marc E. Lenburg, Katrina B. Morshead, Alexander R. Abbas, Joseph R. Arron, Avrum Spira, Tillie-Louise Hackett, Thomas V. Colby, Christopher J. Ryerson, Raymond T. Ng, James C. Hogg
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103325- (2021)
Background: The transition from normal lung anatomy to minimal and established fibrosis is an important feature of the pathology of idiopathic pulmonary fibrosis (IPF). The purpose of this report is to examine the molecular and cellular mechanisms as
Externí odkaz:
https://doaj.org/article/26f5a885d9724d8aa67297d80c625a69
Autor:
John E. McDonough, Dries S. Martens, Naoya Tanabe, Farida Ahangari, Stijn E. Verleden, Karen Maes, Geert M. Verleden, Naftali Kaminski, James C. Hogg, Tim S. Nawrot, Wim A. Wuyts, Bart M. Vanaudenaerde
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-8 (2018)
Abstract Background Idiopathic pulmonary fibrosis is a fatal lung disease characterized by a progressive formation of fibroblastic foci in the interstitium. This disease is strongly associated with telomere dysfunction but the extent of telomere shor
Externí odkaz:
https://doaj.org/article/ae124e68ffdb4984ba61b81e738b688f
Autor:
Stephanie Everaerts, Elise J. Lammertyn, Dries S. Martens, Laurens J. De Sadeleer, Karen Maes, Aernoud A. van Batenburg, Roel Goldschmeding, Coline H. M. van Moorsel, Lieven J. Dupont, Wim A. Wuyts, Robin Vos, Ghislaine Gayan-Ramirez, Naftali Kaminski, James C. Hogg, Wim Janssens, Geert M. Verleden, Tim S. Nawrot, Stijn E. Verleden, John E. McDonough, Bart M. Vanaudenaerde
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Telomere shortening has been associated with several lung diseases. However, telomere length is generally measured in peripheral blood leucocytes rather than in lung tissue, where disease occurs. Consequently, telomere dynamics ha
Externí odkaz:
https://doaj.org/article/a693c3a6ae3247f2b062f7f17bd4090c