Zobrazeno 1 - 10
of 34
pro vyhledávání: '"John E. McLaughlin"'
Trichothecene Mycotoxins Inhibit Mitochondrial Translation—Implication for the Mechanism of Toxicity
Publikováno v:
Toxins, Vol 3, Iss 12, Pp 1484-1501 (2011)
Fusarium head blight (FHB) reduces crop yield and results in contamination of grains with trichothecene mycotoxins. We previously showed that mitochondria play a critical role in the toxicity of a type B trichothecene. Here, we investigated the direc
Externí odkaz:
https://doaj.org/article/3091cd1310e043739e0de622e9dcb20b
Autor:
John E. Mclaughlin
Publikováno v:
International Journal of Intelligence and CounterIntelligence. 34:787-794
This is an assessment of the Trump administration’s dealings with the Intelligence Community (IC) in the context of the presidential administrations’ interaction with intelligence in recent decades...
Autor:
Harold N. Trick, Neerja Tyagi, Nilgun E. Tumer, Noura I. Darwish, Jeffrey Garcia-Sanchez, Ruth Dill-Macky, John E. McLaughlin, Susan P. McCormick
Publikováno v:
Phytopathology®. 111:671-683
Trichothecene mycotoxins such as deoxynivalenol (DON) are virulence factors of Fusarium graminearum, which causes Fusarium head blight, one of the most important diseases of small grain cereals. We previously identified a nonspecific lipid transfer p
Autor:
John E. McLaughlin
Publikováno v:
The 2007 Iran Nuclear Estimate Revisited ISBN: 9781003251163
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9102c19e33a708c5b236cc92b82d6e8a
https://doi.org/10.4324/9781003251163-7
https://doi.org/10.4324/9781003251163-7
Publikováno v:
Journal of Biological Chemistry. 294:17848-17862
Ricin undergoes retrograde transport to the endoplasmic reticulum (ER), and ricin toxin A chain (RTA) enters the cytosol from the ER. Previous reports indicated that RTA inhibits activation of the unfolded protein response (UPR) in yeast and in mamma
Autor:
John E. McLaughlin
Publikováno v:
Intelligence and National Security. 36:208-210
The 2007 NIE on Iran was controversial with and condemned by many policymakers, but – in a not untypical irony – shown ultimately to be correct. The controversy stemmed more from form than substanc...
Autor:
John E. McLaughlin
Publikováno v:
International Journal of American Linguistics. 84:359-381
The Central Numic (Uto-Aztecan) dual number marking system on nouns and pronouns is of interest because even though most of the component morphemes involved in the system are reconstructible to Pro...
Autor:
Yuan-Ping Pang, Jewn Giew Park, Shaohua Wang, Anuradha Vummenthala, Rajesh K Mishra, John E McLaughlin, Rong Di, Jennifer Nielsen Kahn, Nilgun E Tumer, Laszlo Janosi, Jon Davis, Charles B Millard
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17883 (2011)
Ribosome-inactivating proteins (RIPs) are toxic because they bind to 28S rRNA and depurinate a specific adenine residue from the α-sarcin/ricin loop (SRL), thereby inhibiting protein synthesis. Shiga-like toxins (Stx1 and Stx2), produced by Escheric
Externí odkaz:
https://doaj.org/article/53849408323445f0af51c1cb09d5cbd0
Publikováno v:
Bioscience Reports
Ricin interacts with the ribosomal P stalk to cleave a conserved adenine from the α-sarcin/ricin loop (SRL) of the rRNA. Ricin toxin A chain (RTA) uses Arg235 as the most critical arginine for binding to the P stalk through electrostatic interaction
Publikováno v:
J Biol Chem
Ricin undergoes retrograde transport to the endoplasmic reticulum (ER), and ricin toxin A chain (RTA) enters the cytosol from the ER. Previous reports indicated that RTA inhibits activation of the unfolded protein response (UPR) in yeast and in mamma