Zobrazeno 1 - 10
of 95
pro vyhledávání: '"John E. Maggio"'
Publikováno v:
Data in Brief, Vol 18, Iss , Pp 1400-1409 (2018)
The formation of the bilirubin oxidation products (BOXes), BOX A ([4-methyl-5-oxo-3-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide]) and BOX B (3-methyl-5-oxo-4-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide), as well as MVM (4-methyl-3-vinylmaleimide) w
Externí odkaz:
https://doaj.org/article/9ddf9870933b430092342c93e32c4d99
Publikováno v:
Data in Brief
Data in Brief, Vol 18, Iss, Pp 1400-1409 (2018)
Data in Brief, Vol 18, Iss, Pp 1400-1409 (2018)
The formation of the bilirubin oxidation products (BOXes), BOX A ([4-methyl-5-oxo-3-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide]) and BOX B (3-methyl-5-oxo-4-vinyl-(1,5-dihydropyrrol-2-ylidene)acetamide), as well as MVM (4-methyl-3-vinylmaleimide) w
Autor:
Dennis J. Selkoe, Igor Klyubin, Dominic M. Walsh, Peter A. Seubert, Alfred T. Welzel, Michael J. Rowan, Beth L. Ostaszewski, John E. Maggio, Shaomin Li, Donald Walker, Ganesh M. Shankar
Publikováno v:
Biochemistry
Evidence for a central role of amyloid β-protein (Aβ) in the genesis of Alzheimer’s disease (AD) has led to advanced human trials of Aβ-lowering agents. The “amyloid hypothesis” of AD postulates deleterious effects of small, soluble forms of
Autor:
Ashima Gupta, Mario Medvedovic, Jerry B. Lingrel, Mary Beth Genter, Ryan R. Walsh, Sarah S. Williams, Linda M. Parysek, Ming Xu, David P. Witte, John E. Maggio, Lique M. Coolen, Anil G. Jegga, Michael N. Lehman, Jianhua Zhang, Bruce J. Aronow, Gregory F. Egnaczyk, Cathy Ley-Ebert, Maureen A. Sartor, Amy E. Moseley
Publikováno v:
Physiological Genomics. 18:167-183
To understand the commitment of the genome to nervous system differentiation and function, we sought to compare nervous system gene expression to that of a wide variety of other tissues by gene expression database construction and mining. Gene expres
Autor:
James D. Pomonis, Gregory F. Egnaczyk, John E. Maggio, Joseph R. Ghilardi, Julie A Schmidt, Patrick W. Mantyh, Christopher M. Peters, Scott D. Rogers
Publikováno v:
PROTEOMICS. 3:689-698
Reactive gliosis is an invariant feature of the pathology of central nervous system (CNS) injury and a major determinant of neuronal survival and regeneration. To begin to understand the alterations in astrocyte protein expression that drive glial ch
Autor:
Christopher M, Peters, Scott D, Rogers, James D, Pomonis, Gregory F, Egnaczyk, Cathy P, Keyser, Julie A, Schmidt, Joseph R, Ghilardi, John E, Maggio, Patrick W, Mantyh, Greg F, Egnazyck
Publikováno v:
Experimental Neurology. 180:1-13
The endothelins (ETs) are a family of peptides that exert their biological effects via two distinct receptors, the endothelin A receptor (ET(A)R) and the endothelin B receptor (ET(B)R). To more clearly define the potential actions of ETs following sp
Autor:
Joseph R. Ghilardi, John E. Maggio, William P. Esler, Patrick W. Mantyh, Joan M. Jennings, Evelyn R. Stimson
Publikováno v:
Journal of Neurochemistry. 66:723-732
The major pathological feature of Alzheimer's disease is the presence of a high density of amyloid plaques in the brain tissue of patients. The plaques are predominantly composed of human beta-amyloid peptide (A beta), a 39-43-mer peptide the neuroto
Autor:
John E. Maggio, Oliver Jonas, Gary R. Strichartz, Douglas E. Raines, Lawrence P. Cogswell, Sonali Parekh
Publikováno v:
Journal of Pharmaceutical Sciences. 90:1407-1423
A novel probe was developed to measure drug association with the F1*S variant of the human serum protein alpha 1‐acid glycoprotein (AGP). The molecule 2‐hydroxy‐3,5‐diiodo‐ N ‐[2(diethylamino)ethyl]benzamide (DEDIC) binds to AGP, quenchin
Autor:
Harry V. Vinters, Yi An Lu, Marcel J. Lachenmann, William P. Esler, Jonathan P. Lee, Patrick W. Mantyh, Joseph R. Ghilardi, Arthur M. Felix, John E. Maggio, Evelyn R. Stimson
Publikováno v:
Journal of Structural Biology. 130:174-183
Brain amyloid composed of the approximately 40-amino-acid human beta-amyloid peptide A beta is integral to Alzheimer's disease pathology. To probe the importance of a conformational transition in Abeta during amyloid growth, we synthesized and examin
Autor:
Arthur Felix, J. W. Peng, Y.-a. Lu, S S. Zhang, M.J. Lachenmann, Shuwei Li, K. Iwata, John E. Maggio, Jongsoon Lee, E.R. Stimson
Publikováno v:
Journal of Structural Biology. 130:130-141
The self-assembly of the soluble peptide Abeta into Alzheimer's disease amyloid is believed to involve a conformational change. Hence the solution conformation of Abeta is of significant interest. In contrast to studies in other solvents, in water Ab