Zobrazeno 1 - 10
of 113
pro vyhledávání: '"John E. Lennard-Jones"'
Publikováno v:
Alimentary Pharmacology & Therapeutics. 3:367-373
Six patients with short intestine (jejunal length 25-70 cm) on long-term parenteral nutrition, needing 4-5 L of intravenous fluid daily, were given octreotide (a somatostatin analogue, SMS 201-995) to investigate whether it would reduce beneficially
Improved maintenance of remission in ulcerative colitis by balsalazide 4 g/day compared with 2 g/day
Autor:
C. A. Rodrigues, C. D. Holdsworth, J. H. Baron, A. M. Hoare, R. J. Polson, Peter McIntyre, S. Manjunatha, M. H. Giaffer, I. G. Barrison, P. C. Thornton, John E. Lennard-Jones, G. S. R. Davies
Publikováno v:
Alimentary Pharmacology & Therapeutics. 6:479-485
The efficacy of two doses of balsalazide for the maintenance of remission in patients with ulcerative colitis was compared in a double-blind multicentre trial. Sixty-five patients received a 2 g daily dose, and 68 a 4 g dose. The patient groups were
Autor:
John E. Lennard-Jones, Stefan Schreiber, Christopher G. Mathew, A Macpherson, Jochen Hampe, Mark E. Curran, Cathryn M. Lewis, Sheila A. Fisher, Alastair Forbes
Publikováno v:
European Journal of Human Genetics. 10:259-265
Inflammatory bowel disease (IBD) is a multifactorial disorder, with both genetic and environmental factors contributing to the two clinical phenotypes of Crohn's disease (CD) and ulcerative colitis (UC). The underlying genetic model is thought to inv
Autor:
John E. Lennard-Jones, Stefan Schreiber, Christopher G. Mathew, Nicolas J. Lynch, Stephen Bridger, Jochen Hampe, Andrew J. Macpherson, Pieter C. F. Stokkers, Mark E. Curran, Susan Daniels, Alastair Forbes
Publikováno v:
Gut, 48(2), 191-197. BMJ Publishing Group
BACKGROUND AND AIMS—Genetic predisposition for inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic linkage studies. Genetic linkage of IBD to chromosome 3 has been observed previously. A high density analysis of ch
Autor:
Robert Saiz, Stefan Schreiber, Silvia Mascheretti, Pieter C. F. Stokkers, Sarah H. Shaw, Nancy J. Leysens, Nicholas J. Lynch, Annette Lantermann, Mark E. Curran, John E. Lennard-Jones, Christopher G. Mathew, Phil Morin, Alastair Forbes, Stephen Bridger, Mudassar M. Mirza, Sander J. H. van Deventer, A Macpherson, Jochen Hampe
Publikováno v:
American journal of human genetics, 65(6), 1647-1655. Cell Press
Inflammatory bowel disease (IBD) is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease and ulcerative colitis phenotypes. Given the immunologic dysregulation in IBD, the human-leukocyte-antigen region o
Autor:
S. Shivananda, John E. Lennard-Jones
Publikováno v:
European Journal of Gastroenterology & Hepatology. 9:353-359
Objective:To compare the methods used for diagnosis and the clinical features of non-specific inflammatory bowel disease (IBD) in the north and south of Europe.Design:A prospective study over 2 years in 1991-3 at eight centres in the north and 12 in
Autor:
John E. Lennard-Jones
Publikováno v:
Gastroenterology. 109:1388-1391
Publikováno v:
Gut. 37:95-99
Training to contract the abdominal muscles effectively and to relax the pelvic floor during defecation straining helps some patients with severe constipation. Hitherto all such training has used a visible or audible signal of sphincter muscle activit
Publikováno v:
Gastroenterology. 108:428-433
Background/Aims: Antineutrophil cytoplasmic antibodies have been reported to occur more frequently in healthy first-degree relatives of patients with ulcerative colitis than in healthy controls. The aim of this study was to determine their prevalence
Autor:
William Connell, Kay H. Wilkinson, Ian C. Talbot, Christopher B. Williams, John E. Lennard-Jones, Ashley B. Price
Publikováno v:
Gastroenterology. 107:934-944
Background/Aims: Cancer surveillance in patients with ulcerative colitis is of unproven benefit. This study assesses the efficacy and analyzes factors limiting the success of a surveillance program during a 21-year period in 332 patients with ulcerat