Zobrazeno 1 - 10
of 56
pro vyhledávání: '"John E. Leet"'
High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.
Autor:
Michael J Wichroski, Jie Fang, Betsy J Eggers, Ronald E Rose, Charles E Mazzucco, Kevin A Pokornowski, Carl J Baldick, Monique N Anthony, Craig J Dowling, Lauren E Barber, John E Leet, Brett R Beno, Samuel W Gerritz, Michele L Agler, Mark I Cockett, Daniel J Tenney
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42609 (2012)
The recent development of a Hepatitis C virus (HCV) infectious virus cell culture model system has facilitated the development of whole-virus screening assays which can be used to interrogate the entire virus life cycle. Here, we describe the develop
Externí odkaz:
https://doaj.org/article/c696c60727114ef3a6359c336e98b64f
Autor:
Xiaohua Stella Huang, Dieter M. Drexler, Xiaoliang Zhuo, John E. Leet, Benjamin M. Johnson, Kyle Parcella, Joseph L. Cantone, Matthew G. Soars, Kathleen W. Mosure, Kap-Sun Yeung, Kyle J. Eastman, Yingzi Wang, John F. Kadow
Publikováno v:
Drug Metabolism and Disposition. 44:1332-1340
During a medicinal chemistry campaign to identify inhibitors of the hepatitis C virus nonstructural protein 5B (RNA-dependent RNA polymerase), a bicyclo[1.1.1]pentane was introduced into the chemical scaffold to improve metabolic stability. The inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b7011e0ca07188f4028e1a99e2be88
https://doi.org/10.1124/dmd.115.069062
https://doi.org/10.1124/dmd.115.069062
Publikováno v:
SLAS Discovery. 19:1409-1414
Plastic labware is used in all processes of modern pharmaceutical research, including compound storage and biological assays. The use of these plastics has created vast increases in productivity and cost savings as experiments moved from glass test t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c2e5f1af768f632b7a5d2e9aefbc36
https://doi.org/10.1177/1087057114551523
https://doi.org/10.1177/1087057114551523
Autor:
Yue-Zhong Shu, Li Ma, Goodrich Jason, R. Marcus Fancher, Makonen Belema, Mingshe Zhu, John E. Leet, W. Griffith Humphreys, Yang Hong, Min Gao, Lopez Omar D, Van N. Nguyen, Benjamin M. Johnson, Weiping Zhao, Wenying Li, Janet Caceres-Cortes, John A. Easter, Shu Y Chang, Xiaohong Liu, Xiaohua Huang, Lawrence G. Hamann
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 44(6)
Daclatasvir is a first-in-class, potent, and selective inhibitor of the hepatitis C virus nonstructural protein 5A replication complex. In support of nonclinical studies during discovery and exploratory development, liquid chromatography-tandem mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d362b783dbf18d775d89ed92b157ad
https://pubmed.ncbi.nlm.nih.gov/27029743
https://pubmed.ncbi.nlm.nih.gov/27029743
Autor:
Donald R. O'Boyle, Denis R. St. Laurent, Nicholas A. Meanwell, Peter T. Nower, Xiaohua Stella Huang, Jeffrey L. Romine, Michael H. Serrano-Wu, Julie A. Lemm, John E. Leet, Milind Deshpande, Scott W. Martin, Lawrence B. Snyder, Min Gao, Jin-Hua Sun, Fukang Yang
Publikováno v:
ACS Medicinal Chemistry Letters. 2:224-229
The iminothiazolidinone BMS-858 (2) was identified as a specific inhibitor of HCV replication in a genotype 1b replicon assay via a high-throughput screening campaign. A more potent analogue, BMS-824 (18), was used in resistance mapping studies, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9796a71c68af7d3ff8dfd38d20920b35
https://doi.org/10.1021/ml1002647
https://doi.org/10.1021/ml1002647
Autor:
John E. Leet, Ravindra W. Tejwani, Louis J. Lombardo, Yueping Zhang, Benjamin M. Johnson, Xiaohong Liu, Rajeev S. Bhide, Donna D. Wei, Ligang Qian, Yue-Zhong Shu, Amrita Kamath
Publikováno v:
Drug Metabolism and Disposition. 36:2475-2483
5-Isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737) is a potent and selective vascular endothelial growth factor receptor-2 antagonist. In this study, liquid chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17763d5d13428db66d51fa223de43d54
https://doi.org/10.1124/dmd.108.022624
https://doi.org/10.1124/dmd.108.022624
Autor:
Xiaohong Liu, Raouf Hussain, David J. Newman, John E. Leet, Craig R. Fairchild, Stella Huang, Dieter M. Drexler, Stephen W. Mamber, David G. I. Kingston, Joseph L. Cantone
Publikováno v:
Journal of Natural Products. 71:460-463
Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc2a0f3d0747f047ecc0c41fb57479
https://doi.org/10.1021/np070523l
https://doi.org/10.1021/np070523l
Publikováno v:
Magnetic Resonance in Chemistry. 45:447-450
We report here the observation of OH…N hydrogen-bond 1hJN, OH scalar coupling in a biologically active natural product. The intramolecular hydrogen bond between the threonine hydroxyl (Thr-OH) group and the thiazolyl nitrogen at the second thiazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54061bfe855b49e2e0e617883b845d02
https://doi.org/10.1002/mrc.1986
https://doi.org/10.1002/mrc.1986
Autor:
Clotilde Bourin, John F. McElroy, John E. Leet, David A. Stock, John B. Hogan, Frederic Machet, Ping Chen, Mark D. Lindner
Publikováno v:
Experimental and Clinical Psychopharmacology. 14:42-51
Amitriptyline and gabapentin are the primary treatments for painful diabetic neuropathy (PDN), and it is clear that they produce beneficial effects, but there are questions about these treatments that have not been adequately addressed. For example,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3570560a395b118212cfd61dc42d80
https://doi.org/10.1037/1064-1297.14.1.42
https://doi.org/10.1037/1064-1297.14.1.42
Autor:
Michael J. Pucci, Goodrich Jason, Junius M. Clark, Alicia Regueiro-Ren, Timothy P. Connolly, Joanne J. Bronson, Dane M. Springer, Xiaohua Stella Huang, John E. Leet, Yasutsugu Ueda
Publikováno v:
Journal of Natural Products. 68:550-553
Nocathiacin I (1) was converted to its deoxy indole analogue, nocathiacin II (2), another natural product, by a unique and facile chemical process. This process was applied to nocathiacin IV (4), generating the lactone analogue of glycothiohexide alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f5d3f6364b12aa4d40c3c1dfaee450
https://doi.org/10.1021/np040225d
https://doi.org/10.1021/np040225d