Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John E. Lallaman"'
Autor:
John E. Lallaman, Jianguo Ji, Wenke Li, Howard E. Morton, Ji Zhang, Francis A. J. Kerdesky, M. Robert Leanna
Publikováno v:
Organic Process Research & Development. 10:512-517
An efficient chemical process for the multikilogram synthesis of ABT-963 (3) is described. The potent and selective COX-2 inhibitor was prepared in four steps in 36% overall isolated yield from commercially available 3,4-difluoroaniline (4). The chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::337a8c24dfdafd064fcba98fe007c78e
https://doi.org/10.1021/op060016v
https://doi.org/10.1021/op060016v
Autor:
Gregory S. Wayne, John E. Lallaman, Lakshmi Bhagavatula, Jonathan P. Pease, Ramiya H. Premchandran, Steven A. King, William H. Arnold, Francis A. J. Kerdesky, Howard E. Morton, Sou-Jen Chang
Publikováno v:
Organic Process Research & Development. 6:869-875
An efficient and practical synthesis of 2‘-O-benzoyl-3-keto-6-O-propargyl-11,12-carbamoyl erythromycin A (4) is described. The semisynthetic macrolide was prepared on large scale in seven steps in 38% overall isolated yield from the readily availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b69503992080c905ff0b708a26f8db0a
https://doi.org/10.1021/op025535m
https://doi.org/10.1021/op025535m
Autor:
Patel Ketan M, Jien-Heh J. Tien, Lawrence Kolaczkowski, Joseph B. Paterson, Arthur J. Cooper, and Peter J. Stengel, Jih-Hua Liu, Daniel J. Plata, Patricia A. Oliver-Shaffer, David A. Riley, Daniel A. Dickman, H. L. Sham, Eric J. Stoner, John E. Lallaman
Publikováno v:
Organic Process Research & Development. 4:264-269
A large scale process for the synthesis of HIV protease inhibitor candidate ABT-378 has been developed which utilizes an intermediate common to the synthesis of ritonavir, Abbott's first generation compound. The synthesis relies on the sequential acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ee1d1cf451e53c6ebab1944c57cf71
https://doi.org/10.1021/op990202j
https://doi.org/10.1021/op990202j
Publikováno v:
The Journal of Organic Chemistry. 71:1725-1727
Ketoester 1 is cyclized to give pyran-3,5-dione 2 in 78% yield using a parallel addition of ketoester 1 and base NaO(t)Bu in refluxing THF. Compared to the previously reported procedures, these optimized conditions have significantly increased the yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f8848c813ef7fe7417168f9b762707
https://doi.org/10.1021/jo052226w
https://doi.org/10.1021/jo052226w