Zobrazeno 1 - 10
of 214
pro vyhledávání: '"John E. Ladbury"'
Autor:
Christopher M. Jones, Arndt Rohwedder, Kin Man Suen, Safoura Zahed Mohajerani, Antonio N. Calabrese, Sabine Knipp, Mark T. Bedford, John E. Ladbury
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35480- (2024)
Receptor tyrosine kinase (RTK) overexpression is linked to the development and progression of multiple cancers. RTKs are classically considered to initiate cytoplasmic signalling pathways via ligand-induced tyrosine phosphorylation, however recent ev
Externí odkaz:
https://doaj.org/article/756db033cc9a4969828da63cff6be9ba
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The absence of early diagnosis contributes to oesophageal cancer being the sixth most common cause of global cancer-associated deaths, with a 5-year survival rate of
Externí odkaz:
https://doaj.org/article/2b42123cac1448689595e1ccc6a4c804
Autor:
Chi-Chuan Lin, Lukasz Wieteska, Guillaume Poncet-Montange, Kin Man Suen, Stefan T. Arold, Zamal Ahmed, John E. Ladbury
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Receptor tyrosine kinases (RTKs) are typically activated through a precise sequence of intracellular phosphorylation events starting with a tyrosine residue on the activation loop (A-loop) of the kinase domain (KD). From this point the mono-
Externí odkaz:
https://doaj.org/article/1eb049e9217d4b42a3ef681bf1ba97aa
Autor:
Amy K. Stainthorp, Chi-Chuan Lin, Dapeng Wang, Ragini Medhi, Zamal Ahmed, Kin Man Suen, Eric A. Miska, Adrian Whitehouse, John E. Ladbury
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Protein interactions with the microRNA (miRNA)-mediated gene silencing protein Argonaute 2 (AGO2) control miRNA expression. miRNA biogenesis starts with the production of precursor transcripts and culminates with the loading of mature miRNA
Externí odkaz:
https://doaj.org/article/756e1110262445a7a318ca1ffe0841ca
Autor:
Caroline Seiler, Amy K. Stainthorp, Sophie Ketchen, Christopher M. Jones, Kate Marks, Philip Quirke, John E. Ladbury
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
The Grb2 splice variant Grb3-3 results in decreased activation of the Ras-MAPK pathway due competition with Grb2 for SOS binding, with reduced Grb3-3 levels observed in tumour tissue suggestive of a mechanism for enhancing Ras pathway activity.
Externí odkaz:
https://doaj.org/article/cfc96b6f633f437e925d3d36fc562c13
Autor:
Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John E. Ladbury
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of
Externí odkaz:
https://doaj.org/article/edb9c4facda0446e8198cbaac3dd988c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcome
Externí odkaz:
https://doaj.org/article/da6ab08961324858bf419780f90c8fa2
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 8, Iss 10, Pp n/a-n/a (2020)
Abstract Background Repressor element 1‐silencing transcription factor (REST) acts as a transcriptional repressor by recruiting several chromatin modifiers, including histone deacetylase (HDAC). Elevated REST expression in medulloblastoma has been
Externí odkaz:
https://doaj.org/article/898621f0f88f4816a828de520e833e11
Autor:
Sophie E. Ketchen, Filomena O. Gamboa-Esteves, Sean E. Lawler, Michal O. Nowicki, Arndt Rohwedder, Sabine Knipp, Sally Prior, Susan C. Short, John E. Ladbury, Anke Brüning-Richardson
Publikováno v:
Biomedicines, Vol 10, Iss 1, p 9 (2021)
Cancer cell invasion is a precondition for tumour metastasis and represents one of the most devastating characteristics of cancer. The development of drugs targeting cell migration, known as migrastatics, may improve the treatment of highly invasive
Externí odkaz:
https://doaj.org/article/b3ae45dc331647029ff3446020ce20a5
Autor:
Gareth W. Fearnley, Izma Abdul-Zani, Antony M. Latham, Monica C. Hollstein, John E. Ladbury, Stephen B. Wheatcroft, Adam F. Odell, Sreenivasan Ponnambalam
Publikováno v:
Biology Open, Vol 8, Iss 5 (2019)
New blood vessel sprouting (angiogenesis) and vascular physiology are fundamental features of metazoan species but we do not fully understand how signal transduction pathways regulate diverse vascular responses. The vascular endothelial growth factor
Externí odkaz:
https://doaj.org/article/ef45472a0e93452798833e10eec2a677