Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John E. Hengeveld"'
Autor:
Thaddeus S. Franczyk, Lawrence Kolaczkowski, James C. Marek, Donna K. Montavon, Maureen A. McLaughlin, Guangxin Liang, Anthony R. Haight, Vincent S. Chan, Travis B. Dunn, John E. Hengeveld, David M. Barnes, Jufang Barkalow, Shashank Shekhar, Brian J. Kotecki, James J. Napier
Publikováno v:
The Journal of Organic Chemistry. 84:4873-4892
Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed
Autor:
David M. Barnes, Jufang Barkalow, Yong Chen, Francis A. J. Kerdesky, John E. Hengeveld, Anthony R. Haight, Bryan Macri, Ashok K. Gupta, Agnes Pal, Brian J. Kotecki
Publikováno v:
Organic Process Research & Development. 13:225-229
The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine is described. We have found that the crystallization of a racemic mixture of the base with tartaric acid led to a salt in which the undesired enantiomer is incorpo
Publikováno v:
Tetrahedron. 36:2701-2710
A reaction sequence has been developed for preparing hydroazulenones suitable for total synthesis of pseudoguaiane sesquiterpenes (→1 →2 →4). The relative configuration of bicyclic ketone 2 at three chiral centers was established by its convers
Publikováno v:
Tetrahedron Letters. 24:139-142
The total synthesis of the title compound via an intramolecular aldol condensation, and the novel use of the trimethylsilylethyl ester as a carboxyl protecting group in carbapenem systems, are reported.