Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John E. Froberg"'
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 112995- (2023)
Summary: Investigation of translation in rare cell types or subcellular contexts is challenging due to large input requirements for standard approaches. Here, we present “nanoRibo-seq” an optimized approach using 102- to 103-fold less input mater
Externí odkaz:
https://doaj.org/article/42a16162a3e542219ca4125af0ae847e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest
Externí odkaz:
https://doaj.org/article/f77d839a60d344f6adff030162be5749
Publikováno v:
SSRN Electronic Journal.
While increasingly powerful approaches enable investigation of transcription using small samples of RNA, approaches to investigate translational regulation in small populations of specific cell types, and/or (sub)-cellular contexts are lacking. Compr
Publikováno v:
Proceedings of the National Academy of Sciences. 114:10654-10659
X chromosome inactivation is an epigenetic dosage compensation mechanism in female mammals driven by the long noncoding RNA, Xist. Although recent genomic and proteomic approaches have provided a more global view of Xist's function, how Xist RNA loca
Autor:
Barry Kesner, John E. Froberg, Hyun Jung Oh, Fei Ji, Hsueh-Ping Chu, Ruslan I. Sadreyev, Stefan F. Pinter, Jeannie T. Lee
Publikováno v:
Nature structural & molecular biology
In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a require
Publikováno v:
Trends in Biochemical Sciences. 39:35-43
Large scale mapping of transcriptomes has revealed significant levels of transcriptional activity within both unannotated and annotated regions of the genome. Interestingly, many of the novel transcripts demonstrate tissue-specific expression and som
Publikováno v:
Science (New York, N.Y.). 356(6343)
Chen et al . (Reports, 28 October 2016, p. 468) proposed that an interaction between Xist RNA and Lamin B receptor (LBR) is necessary and sufficient for Xist spreading during X-chromosome inactivation. We reanalyzed their data and found that reported
Publikováno v:
Journal of Molecular Biology. 425:3698-3706
The recent revolution in sequencing technology has helped to reveal a large transcriptome of long non-coding RNAs (lncRNAs). A major challenge in the years to come is to determine what biological functions, if any, they serve. Although the purpose of
Autor:
Bernhard Payer, Myriam Boukhali, Hongjae Sunwoo, Jeannie T. Lee, Barry Kesner, Derek Lessing, Anand Minajigi, David Colognori, John E. Froberg, Chunyao Wei, Wilhelm Haas
Publikováno v:
Science. 349
INTRODUCTION The mammal has evolved an epigenetic mechanism to silence one of two X chromosomes in the XX female to equalize gene dosages with the XY male. Once established, the inactivated X chromosome (Xi) is extremely stable and is maintained thro