Zobrazeno 1 - 10
of 111
pro vyhledávání: '"John E. Folk"'
Publikováno v:
Pain Research and Treatment
Pain Research and Treatment, Vol 2012 (2012)
Pain Research and Treatment, Vol 2012 (2012)
Delta opioid agonists enhance antinociceptive effects of mu-opioid agonists in many preclinical assays of acute nociception, but delta/mu interactions in preclinical models of inflammation-associated pain have not been examined. This study examined i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a343b2ba2bde268c3c8cc4a1f39c8d89
https://doi.org/10.1155/2012/867067
https://doi.org/10.1155/2012/867067
Autor:
Feng Li, Jason A. Deck, Arthur E. Jacobson, Jeffrey R. Deschamps, Kenner C. Rice, Kejun Cheng, Christina M. Dersch, Richard B. Rothman, John E. Folk, Muneaki Kurimura
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:4330-4337
N-Phenethyl-substituted ortho-a and para-a oxide-bridged phenylmorphans have been obtained through an improved synthesis and their binding affinity examined at the various opioid receptors. Although the N-phenethyl substituent showed much greater aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6651c4304b3c787d2961ed9a14e34620
https://doi.org/10.1016/j.bmc.2011.05.035
https://doi.org/10.1016/j.bmc.2011.05.035
Autor:
Masaaki Sokabe, John E. Folk, Jong Hwan Park, Seung Bum Lee, Jason A. Deck, Christopher S. Fraser, Anthony E. Pegg, Myung Hee Park
Publikováno v:
Biochemical Journal. 433:205-213
eIF5A (eukaryotic translation initiation factor 5A) is the only cellular protein containing hypusine [Nϵ-(4-amino-2-hydroxybutyl)lysine]. eIF5A is activated by the post-translational synthesis of hypusine and the hypusine modification is essential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c93a37af38b430a5054ac197e956300
https://doi.org/10.1042/bj20101322
https://doi.org/10.1042/bj20101322
Publikováno v:
Pharmacology Biochemistry and Behavior. 97:205-212
Mu-opioid receptor agonists such as fentanyl are effective analgesics, but their clinical use is limited by untoward effects. Adjunct medications may improve the effectiveness and/or safety of opioid analgesics. This study compared interactions betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44047920c8bc4f29e7695deeaa7bdd9c
https://doi.org/10.1016/j.pbb.2010.07.019
https://doi.org/10.1016/j.pbb.2010.07.019
Publikováno v:
Life Sciences. 86:385-392
Aims Repeated treatment with morphine increases antinociceptive effects of delta opioid agonists in rodents by a mechanism that may involve increased cell-surface expression of delta receptors. The present study evaluated effects of repeated morphine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241059390f3c45cbe63879e1c4d88b69
https://doi.org/10.1016/j.lfs.2010.01.006
https://doi.org/10.1016/j.lfs.2010.01.006
Autor:
Kenner C. Rice, Gail Pereira Do Carmo, William A. Carlezon, Elena H. Chartoff, S. Stevens Negus, John E. Folk
Publikováno v:
European Journal of Pharmacology. 604:58-65
Delta opioid receptor agonists are under development for a variety of clinical applications, and some findings in rats raise the possibility that agents with this mechanism have abuse liability. The present study assessed the effects of the non-pepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae83af459ec71d4990ee983988aec50
https://doi.org/10.1016/j.ejphar.2008.12.021
https://doi.org/10.1016/j.ejphar.2008.12.021
Autor:
Arthur J.L. Cooper, John E. Folk, John P. Blass, Wayne R. Matson, Marc Yudkoff, Susan E. Browne, Mikhail B. Bogdanov, Lawrence Steinman, Thomas M. Jeitner, Yevgeny Daikhin, M. Flint Beal
Publikováno v:
Journal of Neurochemistry. 79:1109-1112
Pathological-length polyglutamine (Q(n)) expansions, such as those that occur in the huntingtin protein (htt) in Huntington's disease (HD), are excellent substrates for tissue transglutaminase in vitro, and transglutaminase activity is increased in p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f794cece61434315ae4dc8da4a36ff7f
https://doi.org/10.1046/j.1471-4159.2001.00673.x
https://doi.org/10.1046/j.1471-4159.2001.00673.x
Publikováno v:
Journal of Neurochemistry. 106:37-44
Transglutaminases (TGases) catalyze several reactions with protein substrates, including formation of gamma-glutamyl-epsilon-lysine cross-links and gamma-glutamylpolyamine residues. The resulting gamma-glutamylamines are excised intact during proteol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d5063551ad8d5d3daea2fd5490a8fa
https://doi.org/10.1111/j.1471-4159.2008.05350.x
https://doi.org/10.1111/j.1471-4159.2008.05350.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 324:714-724
The nonpeptidic delta-opioid agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] produces many stimulant-like behavioral effects in rodents and monkeys, such as locomotor stimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d8fdad4fb993eda0868d3ad8413778
https://doi.org/10.1124/jpet.107.123844
https://doi.org/10.1124/jpet.107.123844
Publikováno v:
Synthesis. 2007:1547-1553
A new synthesis that eliminates the need for chromatographic separation in order to obtain multigram quantities of J-113397, a competitive antagonist of the N/OFQ-NOP receptor system, is reported. N-Benzyl protected 4-oxopiperidinecarboxylate was use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19643b5dde94b0143a570b7c0d37be59
https://doi.org/10.1055/s-2007-966037
https://doi.org/10.1055/s-2007-966037