Extracellular application of the N-methyl-D-aspartate receptor allosteric modulator rapastinel acts remotely to regulate Ca2+ inactivation at an intracellular locus

Autor: Xiao-lei Zhang, Nils A. Berglund, Jeffrey S. Burgdorf, John E. Donello, Joseph R. Moskal, Patric K. Stanton

Publikováno v: Zhang, X L, Berglund, N A, Burgdorf, J S, Donello, J E, Moskal, J R & Stanton, P K 2022, ' Extracellular application of the N-methyl-D-aspartate receptor allosteric modulator rapastinel acts remotely to regulate Ca 2+ inactivation at an intracellular locus ', NeuroReport, vol. 33, no. 7, pp. 312-319 . https://doi.org/10.1097/WNR.0000000000001787

Background A novel N-methyl-D-aspartate receptor (NMDAR) allosteric modulator, rapastinel (RAP, formerly GLYX-13), elicits long-lasting antidepressant-like effects by enhancing long-term potentiation (LTP) of synaptic transmission. RAP elicits these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857d7e1097f3ea8cd8e86e4ca126be02
https://pubmed.ncbi.nlm.nih.gov/35594441

Rapastinel, an NMDAR positive modulator, produces distinct behavioral, sleep, and EEG profiles compared with ketamine

Autor: Brendan D. Hare, Ronald S. Duman, John E. Donello, Pradeep Banerjee

Publikováno v: Behavioural brain research. 391

Rapastinel, a positive NMDAR modulator, produces rapid-acting and long-lasting antidepressant-like effects; however, unlike ketamine, the abuse potential for rapastinel is minimal. Ketamine has also been shown to induce psychotomimetic/dissociative s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bcf75b52ab9347a8f7158667836d1f
https://pubmed.ncbi.nlm.nih.gov/32461133

A2E and lipofuscin distributions in macaque retinal pigment epithelium are similar to human

Autor: John E. Donello, Rosalie K. Crouch, Patrick Pallitto, Yiannis Koutalos, Julia E Herrmann, E. Ellen Jones, Zsolt Ablonczy, Richard R. Drake

Publikováno v: Photochemical & Photobiological Sciences. 14:1888-1895

The accumulation of lipofuscin, an autofluorescent aging marker, in the retinal pigment epithelium (RPE) has been implicated in the development of age-related macular degeneration (AMD). Lipofuscin contains several visual cycle byproducts, most notab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45014d8d425af9a384c18b42c7f8c4f
https://doi.org/10.1039/c5pp00170f

Transient allodynia pain models in mice for early assessment of analgesic activity

Autor: John E. Donello, D. W. Gil, Cynthia V. Cheevers

Publikováno v: British Journal of Pharmacology. 153:769-774

Background and purpose: The most common preclinical models of neuropathic pain involve surgical ligation of sensory nerves, which is especially difficult in mice. Transient models of chemically sensitized allodynia are potentially useful for rapidly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67a3d481f30657d792809e077cb65397
https://doi.org/10.1038/sj.bjp.0707412

Broad modulation of neuropathic pain states by a selective estrogen receptor beta agonist

Autor: Daniel W. Gil, Cindy Cheevers, Andria L. Del Tredici, Birgitte W. Lund, Carsten B. Andersen, Luis R. Gardell, John E. Donello, Hans H. Schiffer, Roger Olsson, Luke C. Fairbairn, Magnus Gustafsson, Fabrice Piu, Lene Hyldtoft, Mark R. Brann

Publikováno v: European journal of pharmacology. 590(1-3)

The effects of estrogens on pain perception remain controversial. In animal models, both beneficial and detrimental effects of non-selective estrogens have been reported. ERb-131 a non-steroidal estrogen receptor beta ligand was evaluated in several

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3919ff3da06fc074f3d60f8e3321bc10
https://pubmed.ncbi.nlm.nih.gov/18559275