Zobrazeno 1 - 10
of 33
pro vyhledávání: '"John E. Dominy"'
Autor:
Mark P. Jedrychowski, Steven P. Gygi, Marta Isasa, Patrick R. Griffin, Jose M. Orozco, Yoonjin Lee, Kfir Sharabi, John E. Dominy, Clint D.J. Tavares, Pere Puigserver, Theodore M. Kamenecka
Publikováno v:
Journal of Biological Chemistry. 291:10635-10645
Methionine is an essential sulfur amino acid that is engaged in key cellular functions such as protein synthesis and is a precursor for critical metabolites involved in maintaining cellular homeostasis. In mammals, in response to nutrient conditions,
Autor:
Kyle L. Hoehn, Brandon M. Kenwood, Valeria R. Mas, Robert T. Lawrence, David S. Breen, Frances L. Byrne, Gregory J. Cooney, Pere Puigserver, David E. James, Stephen H. Caldwell, Jenny D.Y. Chow, Jason A. Liao, Carolin Lackner, Saeko Okutsu, Jose L. Tomsig, John E. Dominy, Marin E. Healy, Nigel Turner, Judit Villén
Publikováno v:
Molecular Metabolism
Lipid deposition in the liver is associated with metabolic disorders including fatty liver disease, type II diabetes, and hepatocellular cancer. The enzymes acetyl-CoA carboxylase 1 (ACC1) and ACC2 are powerful regulators of hepatic fat storage; ther
Autor:
Pere Puigserver, Joao Paulo Camporez, Xiaoyong Yang, Michael J. Jurczak, Ji Hong Lim, Yoonjin Lee, Helen Chim, Francisca Vazquez, Gerald I. Shulman, Piotr Sicinski, Nicola Tolliday, John E. Dominy, Hai Bin Ruan, Yoon Jong Choi
Publikováno v:
Nature
Insulin constitutes a principal evolutionarily conserved hormonal axis for maintaining glucose homeostasis; dysregulation of this axis causes diabetes. PGC-1α (peroxisome-proliferator-activated receptor-γ coactivator-1α) links insulin signalling t
Publikováno v:
Journal of Clinical Investigation. 123:973-979
The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and c
Autor:
Sungjin Kim, Pere Puigserver, John E. Dominy, Zachary Gerhart-Hines, Yoonjin Lee, Yang Kevin Xiang, Mitsuhisa Tabata, Ji Hong Lim
Publikováno v:
Journal of Biological Chemistry. 288:7117-7126
Fatty acids are essential components of the dynamic lipid metabolism in cells. Fatty acids can also signal to intracellular pathways to trigger a broad range of cellular responses. Oleic acid is an abundant monounsaturated omega-9 fatty acid that imp
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 293:E62-E69
Cysteine levels are carefully regulated in mammals to balance metabolic needs against the potential for cytotoxicity. It has been postulated that one of the major regulators of intracellular cysteine levels in mammals is cysteine dioxygenase (CDO). H
Autor:
Martha H. Stipanuk, John E. Dominy
Publikováno v:
Amino Acids. 30:251-256
The modeling of whole organism sulfur amino acid flux control has been aided in recent years by advancements in proteomics and mass spectroscopy-based metabolite analysis. The convergence of these two fields and their respective techniques, as demons
Publikováno v:
Biochemical Journal. 394:267-273
Mammalian metabolism of ingested cysteine is conducted principally within the liver. The liver tightly regulates its intracellular cysteine pool to keep levels high enough to meet the many catabolic and anabolic pathways for which cysteine is needed,
Autor:
John E. Dominy, Martha H. Stipanuk
Publikováno v:
Nutrition Reviews. 62:348-353
Autor:
John E. Dominy, Martha H. Stipanuk
Publikováno v:
Nutrition Reviews. 62:348-353
The enzymes of the transsulfuration pathway also have the capacity to catalyze the desulfhydration of cysteine. Recent studies demonstrate a role of the transsulfuration enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, in catalyzin