Zobrazeno 1 - 10
of 11
pro vyhledávání: '"John E. DeLorbe"'
Publikováno v:
ACS Medicinal Chemistry Letters. 1:448-452
The thermodynamic and structural effects of macrocyclization as a tactic for stabilizing the biologically active conformation of Grb2 SH2 binding peptides were investigated using isothermal titration calorimetry and X-ray crystallography. 23-Membered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42daf4081cdeac9b2ae9eade8de272a3
https://doi.org/10.1021/ml100142y
https://doi.org/10.1021/ml100142y
Autor:
John H. Clements, Laura E. Millspaugh, Stephen F. Martin, Aaron P. Benfield, John E. DeLorbe, Hilary R. Plake, Martin G. Teresk
Publikováno v:
Journal of the American Chemical Society. 131:16758-16770
Succinate- and cyclopropane-derived phosphotyrosine (pY) replacements were incorporated into a series of Grb2 SH2 binding ligands wherein the pY+1 residue was varied to determine explicitly how variations in ligand preorganization affect binding ener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8833ad65be12cd6ebf909b19c4abbd5
https://doi.org/10.1021/ja904698q
https://doi.org/10.1021/ja904698q
Publikováno v:
ACS medicinal chemistry letters. 4(11)
Thermodynamic parameters were determined for complex formation between the Grb2 SH2 domain and tripeptides of the general form Ac-pTyr-Xaa-Asn in which the Xaa residue bears a linear alkyl chain varying in length from 1–5 carbon atoms. Binding affi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d144b9f033ce12d4317b411af7d918
https://pubmed.ncbi.nlm.nih.gov/24349642
https://pubmed.ncbi.nlm.nih.gov/24349642
Autor:
Steven M. Mennen, Sangkil Nam, Fang-Li Zhang, David Horne, Richard Jove, Larry E. Overman, John E. DeLorbe
A common strategy for preparing tryptophan-derived epidithiodioxopiperazine (ETP) natural products containing a hydroxyl substituent adjacent to a quaternary carbon stereocenter is reported. This strategy is exemplified by enantioselective total synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c417ebb215d0c235a0c0cb7eed2f3783
https://europepmc.org/articles/PMC3640572/
https://europepmc.org/articles/PMC3640572/
Thermodynamic parameters were determined for complex formation between the Grb2 SH2 domain and Ac-pTyr-Xaa-Asn derived tripeptides in which the Xaa residue is an α,α-cycloaliphatic amino acid that varies in ring size from three- to seven-membered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e977614d1c0a9b551455c589802fadbd
https://europepmc.org/articles/PMC3218293/
https://europepmc.org/articles/PMC3218293/
A concise second-generation total synthesis of the fungal-derived alkaloid (+)-gliocladin C (11) in 10 steps and 11% overall yield from isatin is reported. In addition, the epipolythiodioxopiperazine (ETP) natural product (+)-gliocladine C (6) has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad2b436a06f0cfc98f77f53cc05937a
https://europepmc.org/articles/PMC3090078/
https://europepmc.org/articles/PMC3090078/
Publikováno v:
ACS medicinal chemistry letters. 1(8)
The thermodynamic and structural effects of macrocyclization as a tactic for stabilizing the biologically-active conformation of Grb2 SH2 binding peptides were investigated using isothermal titration calorimetry and x-ray crystallography. 23-Membered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a720145dbda7b89436002c2b51ad1c61
https://pubmed.ncbi.nlm.nih.gov/21116482
https://pubmed.ncbi.nlm.nih.gov/21116482
Publikováno v:
ChemInform. 41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e88d3f57bf4ea76cf848d94f14d80cc6
https://doi.org/10.1002/chin.201032202
https://doi.org/10.1002/chin.201032202
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 66(Pt 10)
Structures of the Grb2 SH2 domain complexed with a series of pseudopeptides containing flexible (benzyl succinate) and constrained (aryl cyclopropanedicarboxylate) replacements of the phosphotyrosine (pY) residue in tripeptides derived from Ac-pYXN-N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6731f06ece7cdda91bc5dcc0091a9d
https://pubmed.ncbi.nlm.nih.gov/20944243
https://pubmed.ncbi.nlm.nih.gov/20944243
Publikováno v:
Organic letters. 12(7)
A concise total synthesis of the Lycopodium alkaloid lycopladine A (1) is described that features sequential conjugate addition and enolate arylation reactions to construct the tricyclic core in two steps.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96858ea758e22eb43ce3f87141908ee8
https://pubmed.ncbi.nlm.nih.gov/20196615
https://pubmed.ncbi.nlm.nih.gov/20196615