Zobrazeno 1 - 10
of 18
pro vyhledávání: '"John E. Creange"'
Publikováno v:
Fertility and Sterility. 30:86-90
Azastene (4,4,17α-trimethylandrost-5-eno [2,3-d]isoxazol-17-ol), when given orally to rats at a dose of 12 mg/kg once on day 10 of pregnancy, induced resorption of all fetuses and a precipitous decline of circulating progesterone levels in all test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ba6e7dcb6e4ba9b076aee76b7b51435
https://doi.org/10.1016/s0015-0282(16)43401-1
https://doi.org/10.1016/s0015-0282(16)43401-1
Publikováno v:
Endocrinology. 114:1983-1989
The synthetic steroid nivazol lacks three of the substituents considered to be important for glucocorticoid activity, i.e. the 3-keto, the 11-hydroxy, and the 20-keto groups. Nevertheless, in the rat, nivazol has the activity profile of a glucocortic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a99dc39c6bc6114a05e0a002b87eec8
https://doi.org/10.1210/endo-114-6-1983
https://doi.org/10.1210/endo-114-6-1983
Publikováno v:
Fertility and Sterility. 30:343-347
Azastene is an orally effective "luteolytic" agent in rhesus monkeys. In nonpregnant monkeys it reverses the human chorionic gonadotropin-stimulated increase in progesterone production and delay in the onset of menstruation, and in inseminated monkey
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::258bd4274eac43327228e039b81b682a
https://doi.org/10.1016/s0015-0282(16)43523-5
https://doi.org/10.1016/s0015-0282(16)43523-5
Publikováno v:
Contraception. 24:289-299
Win 32,729 [(2 alpha, 4 alpha, 5 alpha, 17 beta)-4,5-epoxy-17-hydroxy-4,17-dimethyl-3-oxoandrostane-2-carbonitrile] is an orally active interceptive agent in rats and rhesus monkeys (M mulatta). A single oral dose of 48 mg/kg terminated gestation whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd598501da4b4db473d23aa2cb8d7f74
https://doi.org/10.1016/0010-7824(81)90042-1
https://doi.org/10.1016/0010-7824(81)90042-1
Publikováno v:
Endocrinology. 88:427-432
Estrone and estradiol-17β were shown to displace 3H-estradiol-17β from binding sites in plasma of the pregnant rat. The ligand specificity of this plasma differed from that of human pregnancy plasma. In the rat preparation, neither testosterone nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8036a7f7b32b5ab9b8aa7b5544cff871
https://doi.org/10.1210/endo-88-2-427
https://doi.org/10.1210/endo-88-2-427
Autor:
Clara M. Szego, John E. Creange
Publikováno v:
Biochemical Journal. 102:898-904
1. Aerobic incubation of [(14)C]oestradiol, in the presence of surviving gut tissue of the sea urchin Strongylocentrotus franciscanus, or a soluble enzyme system prepared therefrom, resulted in rapid formation of a water-soluble metabolite, identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856c76267f4f5809a5255f17bb563fe3
https://doi.org/10.1042/bj1020898
https://doi.org/10.1042/bj1020898
Autor:
John E. Creange, Sidney Roberts
Publikováno v:
Biochemical and Biophysical Research Communications. 19:73-78
Cyclic 3′,5′-adenosine monophosphate (cyclic 3′,5′-AMP) has recently been shown to stimulate selectively steroid C-11β hydroxylase activity in rat adrenal homogenates fortified with glucose-6-phosphate (G-6-P) and NADP + (Roberts, Creange an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d26ec7ad7319697684db3f4b59078ab
https://doi.org/10.1016/0006-291x(65)90121-x
https://doi.org/10.1016/0006-291x(65)90121-x
Publikováno v:
Nature. 207:188-190
ADENOSINE-3′,5′-monophosphate (cyclic 3 ′,5′-AMP) has been shown to stimulate steroid C–11β hydroxylations in rat adrenal homogenates1 as well as the production of corticosterone from endogenous precursors in surviving rat adrenal sections
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a4960beb2d3c1d6635235f29ad54a8
https://doi.org/10.1038/207188a0
https://doi.org/10.1038/207188a0
Autor:
A. J. Anzalone, Gordon O. Potts, H. C. Neumann, Malcolm R. Bell, Robert G. Christiansen, John E. Creange, H. P. Schane, U. J. Salvador
Publikováno v:
Journal of medicinal chemistry. 27(7)
Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9588fb490e6c2d5d8119c6339a6c5fa
https://pubmed.ncbi.nlm.nih.gov/6330362
https://pubmed.ncbi.nlm.nih.gov/6330362
Publikováno v:
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 177(3)
In rats treated with furosemide, urinary losses of water, sodium and potassium were accompanied by increased circulating levels of aldosterone. Trilostane, an inhibitor of adrenal 3 beta-hydroxysteroid dehydrogenase activity, prevented furosemide-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e897cbed0009a302b85255670e21d7
https://pubmed.ncbi.nlm.nih.gov/6595676
https://pubmed.ncbi.nlm.nih.gov/6595676