Zobrazeno 1 - 10
of 53
pro vyhledávání: '"John E. Chandler"'
Autor:
Scott Gladstein, Luay M. Almassalha, Lusik Cherkezyan, John E. Chandler, Adam Eshein, Aya Eid, Di Zhang, Wenli Wu, Greta M. Bauer, Andrew D. Stephens, Simona Morochnik, Hariharan Subramanian, John F. Marko, Guillermo A. Ameer, Igal Szleifer, Vadim Backman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Methods to track molecular motion in eukaryotic cells mostly rely on fluorescent labels, transfection or photobleaching. Here the authors use multimodal partial wave spectroscopy to perform label-free live cell measurements of nanoscale structure and
Externí odkaz:
https://doaj.org/article/0c957e1c9b824bd39ac73359f6e497aa
Autor:
Greta M. Bauer, Aya Eid, John F. Marko, Luay M. Almassalha, Hariharan Subramanian, Simona Morochnik, Di Zhang, Wenli Wu, John E. Chandler, Guillermo A. Ameer, Scott Gladstein, Vadim Backman, Andrew D. Stephens, Igal Szleifer, Adam Eshein, Lusik Cherkezyan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
Understanding the relationship between intracellular motion and macromolecular structure remains a challenge in biology. Macromolecular structures are assembled from numerous molecules, some of which cannot be labeled. Most techniques to study motion
Autor:
Nicholas M. Anthony, David VanDerway, Reiner Bleher, John E. Chandler, Adam Eshein, Anne R. Shim, Vadim Backman, Wenli Wu, Aya Eid, Surbhi Jain, Greta M. Bauer, Vinayak P. Dravid, Luay M. Almassalha, Igal Szleifer, The-Quyen Nguyen, Emily M. Pujadas, Vasundhara Agrawal, George Esteve, Yue Li, Kai Huang, Xiang Zhou, Juan J. de Pablo, Ranya Virk, Scott Gladstein, Jane Frederick
Publikováno v:
Science Advances
nano-ChIA combines multiple nanoimaging modalities to uncover 4D chromatin organization and its relationship to molecular function.
Extending across multiple length scales, dynamic chromatin structure is linked to transcription through the regul
Extending across multiple length scales, dynamic chromatin structure is linked to transcription through the regul
Autor:
Wenli Wu, Vadim Backman, Igal Szleifer, Vinayak P. Dravid, Kai Huang, Vasundhara Agrawal, The-Quyen Nguyen, Ranya Virk, Yue Li, Adam Eshein, Emily M. Pujadas, Juan J. de Pablo, Aya Eid, Xiang Zhou, Reiner Bleher, Luay M. Almassalha, Greta M. Bauer, Nick Anthony, Scott Gladstein, David VanDerway, Jane Frederick, John E. Chandler
In eukaryotic cells, chromatin structure is linked to transcription processes through the regulation of genome organization. Extending across multiple length-scales - from the nucleosome to higher-order three-dimensional structures - chromatin is a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b20f6b68ece369b07711d8e0dc12ca
Autor:
The-Quyen Nguyen, Sebastian Thompson, Di Zhang, Vadim Backman, Graham Spicer, Ignacio Martínez, Hariharan Subramanian, Ronald Ellis, Luay M. Almassalha, John E. Chandler, Roberto de la Rica, Seth Feder, Scott Gladstein
Publikováno v:
Nanoscale. 10:19125-19130
Gold nanoparticles (GNPs) have become essential tools used in nanobiotechnology due to their tunable plasmonic properties and low toxicity in biological samples. Among the available approaches for imaging GNPs internalized by cells, hyperspectral tec
Autor:
Shohreh Shahabi, Vadim Backman, Di Zhang, Daniel D. Billadeau, Greta M. Bauer, Thomas V. O'Halloran, Igal Szleifer, Andrew P. Mazar, Hemant K. Roy, Wenli Wu, David VanDerway, Alexis Kendra, Lusik Cherkezyan, John E. Chandler, Luay M. Almassalha, Scott Gladstein, Andrey Ugolkov, Brandon Luke L. Seagle
Publikováno v:
Nature Biomedical Engineering. 1:902-913
Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through th
Autor:
Hemant K. Roy, Luay M. Almassalha, Igal Szleifer, Vadim Backman, John E. Chandler, Scott Gladstein, Greta M. Bauer
Publikováno v:
Cancer Research. 76:5605-5609
Results have historically shown a broad plasticity in the origin of tumors and their functions, with significant heterogeneity observed in both morphologies and functional capabilities. Largely unknown, however, are the mechanisms by which these vari
Autor:
Luay M. Almassalha, Biqin Dong, Ben E. Urban, Cheng Sun, The-Quyen Nguyen, Yolanda Stypula-Cyrus, Hao Zhang, Vadim Backman, John E. Chandler
Publikováno v:
Proceedings of the National Academy of Sciences. 113:9716-9721
Visualizing the nanoscale intracellular structures formed by nucleic acids, such as chromatin, in nonperturbed, structurally and dynamically complex cellular systems, will help expand our understanding of biological processes and open the next fronti
Publikováno v:
Functional Ecology. 31:172-183
Summary 1.Corals may reduce the effects of heat-induced bleaching through associations with thermotolerant algal symbionts (Symbiodinium). Although hundreds of Symbiodinium genetic types (phylotypes) are known, thermotolerance has been systematically
Autor:
Aya Eid, Simona Morochnik, Luay M. Almassalha, Vadim Backman, Hariharan Subramanian, Greta M. Bauer, John E. Chandler, Guillermo A. Ameer, Lusik Cherkezyan, Igal Szleifer, Adam Eshein, Andrew D. Stephens, Wenli Wu, Scott Gladstein, Di Zhang, John F. Marko
We present a multimodal label-free interferometric imaging platform for measuring intracellular nanoscale structure and macromolecular dynamics in living cells with a sensitivity to macromolecules as small as 20nm and millisecond temporal resolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf7d56138255d78d5921ef55f5edfb8
https://doi.org/10.1101/428383
https://doi.org/10.1101/428383