Zobrazeno 1 - 10
of 39
pro vyhledávání: '"John E. Bleasdale"'
Autor:
Jane M. Withka, David A. Griffith, John E. Bleasdale, Declan Flynn, Brian J. Stockman, Pat Loulakis, Kay Ahn, Xiayang Qiu, Jessica Ward, David Cunningham, Venkataraman Thanabal, Michelle Pacholec, Alison H. Varghese, Brandon Pabst, Boris A. Chrunyk, Robert S. Garofalo, Matt Griffor
Publikováno v:
Journal of Biological Chemistry. 285:8340-8351
Sirtuins catalyze NAD(+)-dependent protein deacetylation and are critical regulators of transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1-7), and SIRT1 has been implicated as a key mediator of the pathways downstr
Autor:
Heinrich J. Schostarez, F. Craig Stevens, John E. Bleasdale, Theresa J. O’Sullivan, Scott D. Larsen, Charlotta Liljebris, Derek Ogg, Barbara J. Palazuk, Tjeerd Barf, Paul D. May
Publikováno v:
Journal of Medicinal Chemistry. 45:598-622
Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling in part by dephosphorylating key tyrosine residues within the regulatory domain of the beta-subunit of the insulin receptor (IR), thereby attenuating receptor tyrosine kin
Publikováno v:
Molecular and Cellular Endocrinology. 173:109-120
One strategy to treat the insulin resistance that is central to type II diabetes mellitus may be to maintain insulin receptors (IR) in the active (tyrosine phosphorylated) form. Because protein tyrosine phosphatase 1B (PTP1B) binds and subsequently d
The Chilton Conference on Inositol and Phosphoinositides, held on January 9-11, 1984 at Southwestern Medical School, University of Texas Health Science Center, Dallas, Texas, was the third in a series of conferences on cyclitols and phosphoinositides
Autor:
Michael L. Swanson, John E. Bleasdale
Publikováno v:
Drug Development Research. 35:69-82
Pioglitazone and other antidiabetic thiazolidinediones appear to overcome insulin resistance by affecting an unidentified early event in insulin action. Because attempts to determine changes in insulin receptors in tissues from thiazolidinedione-trea
Publikováno v:
British Journal of Pharmacology. 114:1694-1702
1. The effect of NPC 15669, N-carboxy-L-leucine, N-[(2,7-dimethylfluoren-9-yl)methyl]ester), an inhibitor of human polymorphonuclear neutrophil (PMN) adhesion, on granule exocytosis and the oxidative burst was investigated in PMN activated with recep
Publikováno v:
Molecular and Cellular Endocrinology. 102:119-129
Activation of phosphoinositide 3-kinase (PI 3-kinase) is an early event in insulin signal transduction that is blocked completely in adipocytes from insulin-resistant KKAy mice. Treatment of KKAy mice with pioglitazone, an anti-diabetic thiazolidined
Autor:
Stephen K. Fisher, John E. Bleasdale
Publikováno v:
Neuroprotocols. 3:125-133
1-[6-[[17β-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]-hexyl]1H-pyrrole-2,5-dione (U-73122) is an aminosteroid that was identified initially as a potent inhibitor of platelet activation by receptor-specific agonists. U-73122 inhibits receptor-couple
Autor:
John E. Bleasdale, Michael L. Swanson
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1181:240-248
It has been proposed that an abnormality in the regulation of cytosolic-free Ca2+ may be the cause of some forms of insulin resistance. In support of this proposition, it was reported that phospholipase C-catalyzed hydrolysis of phosphatidylinositol
Autor:
Sam P. Mostafapour, Loren C. Denlinger, John E. Bleasdale, Angela K. Thompson, Stephen K. Fisher
Publikováno v:
Journal of Biological Chemistry. 266:23856-23862
The relationship between muscarinic receptor activation of phosphoinositide hydrolysis and the sequestration of cell surface muscarinic receptors has been examined for both intact and digitonin-permeabilized human SK-N-SH neuroblastoma cells. Additio