Výsledky vyhledávání - "John E. Barnum"

Evaluation of the Relative Performance of Pancreas-Specific MicroRNAs in Rat Plasma as Biomarkers of Pancreas Injury

Autor: Thomas Forest, Wendy J. Bailey, Erjia Wang, Zoltan Erdos, John E. Barnum, Warren E. Glaab, Paritosh Markus Dey, Christopher DeMaula

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 173(1)

Drug-induced pancreatic injury (DIPI) has become linked in recent years to many commonly prescribed medications from several pharmacological classes. Diagnosis is currently most often focused on identification of acute pancreatitis and generally base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ae288490fe76d49c10b95b9f5fdb0c
https://pubmed.ncbi.nlm.nih.gov/31504967

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A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury

Autor: Lisa LaFranco-Scheuch, Zoltan Erdos, Katerina Vlasakova, Pamela Lane, Wendy J. Bailey, Warren E. Glaab, Frank D. Sistare, John E. Barnum

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 168(1)

Liver and skeletal muscle-specific microRNAs (miRNAs) are currently being evaluated as novel plasma biomarkers that may out-perform or add value to the conventional liver injury biomarkers alanine aminotransferase (ALT) and aspartate aminotransferase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b769096f87491bb60f5a6cdd03f9e4
https://pubmed.ncbi.nlm.nih.gov/30496518

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Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer

Autor: Kathleen A. McNulty, John E. Barnum, Stephen Pacchione, Jin Shang, Chunhua Qin, Kavitha Bekkari, Rong Liu, Alan Ng, Richard D. Storer, Zhibin Wang

Publikováno v: Molecular Carcinogenesis. 49:54-67

Rodents, mice and rats in particular, are the species of choice for evaluating chemical carcinogenesis. However, different species and strains often respond very differently, undermining the logic of extrapolation of animal results to humans and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cdda312be88c073fc4cf9c7231f95df
https://doi.org/10.1002/mc.20576

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Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage

Autor: John E. Barnum, Andrew R. Kraynak, Troy W. McKelvey, Robert Gealy, Richard D. Storer, Jennifer L. Wright-Bourque

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 629:49-63

In vitro alkaline elution is a sensitive and specific short term assay which measures DNA strand breakage in a mammalian test system (primary rat hepatocytes). This lab has previously demonstrated the performance of the assay with known genotoxic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c450a60fc41aefc8cca35160bf3fe194
https://doi.org/10.1016/j.mrgentox.2007.01.005

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Alkaline comet assay in liver and stomach, and micronucleus assay in bone marrow, from rats treated with 2-acetylaminofluorene, azidothymidine, cisplatin, or isobutyraldehyde

Autor: Sheila M. Galloway, A. Ng, E. Freeland, Caron L. Cunningham, B.A. Ykoruk, John E. Barnum, Andrew R. Kraynak, D. Stoffregen, B. Bennet, M. Merschman

Publikováno v: Mutation research. Genetic toxicology and environmental mutagenesis.

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined the ability of the assay to determine the genotoxicity of 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe31d6c43734023c180835261eb58fec
https://pubmed.ncbi.nlm.nih.gov/26212296

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Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests

Autor: John G. DeLuca, M. Vijayaraj Reddy, George M. Laws, John E. Barnum, Thomas R. Skopek, Crystal G. McKnight, Jennifer P. Gara, Sheila M. Galloway, Joseph F. Sina, Michael J. Armstrong, Richard D. Storer

Publikováno v: Environmental and Molecular Mutagenesis. 40:1-17

3-Methylindole (3MI), melatonin (Mel), serotonin (Ser), and tryptamine (Tryp) were evaluated in vitro for their potential to induce DNA adducts, DNA strand breaks, chromosomal aberrations (Abs), inhibition of DNA synthesis, and mutations. All compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2271fd1f39fc4c80514f4b4bec3c312
https://doi.org/10.1002/em.10088

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Occupational Hazard Evaluation of P-Bromobenzyl Bromide from Tests for Genotoxicity

Autor: Joseph F. Sina, N. N. Kirsten, Richard D. Storer, M. G. Prato, Edward V. Sargent, B. D. Naumann, John E. Barnum, Sheila M. Galloway, T. E. Johnson

Publikováno v: Drug and Chemical Toxicology. 22:583-593

As part of an occupational hazard evaluation, p-bromobenzyl bromide (p-BBB) was evaluated for genotoxic activity in the Ames microbial mutagenicity assay, the alkaline elution assay for DNA strand breaks in rat hepatocytes and the in vitro chromosome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a5a01a15ba93f2e7c807eb601516d
https://doi.org/10.3109/01480549908993169

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Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer

Autor: Chunhua, Qin, Zhibin, Wang, Jin, Shang, Kavitha, Bekkari, Rong, Liu, Stephen, Pacchione, Kathleen A, McNulty, Alan, Ng, John E, Barnum, Richard D, Storer

Publikováno v: Molecular carcinogenesis. 49(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5986fb3121b9c18262fa217a206bb370
https://pubmed.ncbi.nlm.nih.gov/20025072

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Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds

Autor: Richard D. Storer, Troy W. McKelvey, Lori S. Harmon, John G. DeLuca, Warren W. Nichols, Michael C. Elia, John E. Barnum, Andrew R. Kraynak

Publikováno v: Mutation research. 368(2)

The in vitro alkaline elution/rat hepatocyte assay is a sensitive assay for genotoxicity, measured as DNA strand breaks induced in primary cultures of rat hepatocytes after 3-h treatments with test compounds. Since DNA degradation can be rapid and ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d067e81296768fb359698d19d6ccb9
https://pubmed.ncbi.nlm.nih.gov/8684406

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Rapid DNA degradation in primary rat hepatocytes treated with diverse cytotoxic chemicals: analysis by pulsed field gel electrophoresis and implications for alkaline elution assays

Autor: John E. Barnum, Richard D. Storer, Lori S. Harmon, John G. DeLuca, Warren W. Nichols, Troy W. McKelvey, Andrew R. Kraynak, Michael C. Elia

Publikováno v: Environmental and molecular mutagenesis. 24(3)

The use of genetic toxicology tests for hazard identification is complicated by the fact that some in vitro tests using cultured mammalian cells are subject to potential artifacts that can make it difficult to distinguish between direct, chemically-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5739d482f89ea4109ddcd644a8f32acb
https://pubmed.ncbi.nlm.nih.gov/7957122

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