Zobrazeno 1 - 10
of 338
pro vyhledávání: '"John E Smith"'
Autor:
Johan Lindqvist, Weikang Ma, Frank Li, Yaeren Hernandez, Justin Kolb, Balazs Kiss, Paola Tonino, Robbert van der Pijl, Esmat Karimi, Henry Gong, Josh Strom, Zaynab Hourani, John E. Smith, Coen Ottenheijm, Thomas Irving, Henk Granzier
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nebulin-based nemaline myopathy is a heterogenous disease with unclear pathological mechanisms. Here, the authors generate a mouse model that mimics the most common genetic cause of the disease and demonstrate that muscle weakness in this model is as
Externí odkaz:
https://doaj.org/article/fb151f3beab74614afcba240bd5ebe48
Autor:
Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith, Jeffrey S. Chamberlain, Henk Granzier
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Background Nebulin is a critical thin filament-binding protein that spans from the Z-disk of the skeletal muscle sarcomere to near the pointed end of the thin filament. Its massive size and actin-binding property allows it to provide the thi
Externí odkaz:
https://doaj.org/article/667904beb85d45bf8b0810fff5560535
Autor:
Thomas Lanzicher, Tiankun Zhou, Chandra Saripalli, Vic Keschrumrus, John E. Smith III, Olga Mayans, Orfeo Sbaizero, Henk Granzier
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Titin is a large filamentous protein that forms a sarcomeric myofilament with a molecular spring region that develops force in stretched sarcomeres. The molecular spring has a complex make-up that includes the N2A element. This element largely consis
Externí odkaz:
https://doaj.org/article/4b14674ac8e34676a1fa21d9d3f71407
Autor:
Abu Bakar Sallen, John E. Smith
Publikováno v:
ASEAN Journal on Science and Technology for Development, Vol 2, Iss 1, Pp 37-48 (2017)
Externí odkaz:
https://doaj.org/article/0a8a3721f8fc4d2096d4b1d560b7cbd0
Autor:
Paola Tonino, Balazs Kiss, Josh Strom, Mei Methawasin, John E. Smith, Justin Kolb, Siegfried Labeit, Henk Granzier
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
Externí odkaz:
https://doaj.org/article/4aefdc45145b406c95a8fd2a8dd9dabe
Autor:
Frank Li, Justin Kolb, Julie Crudele, Paola Tonino, Zaynab Hourani, John E. Smith, Jeffrey S. Chamberlain, Henk Granzier
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-1 (2020)
Following the publication of this paper [1], it was brought to the authors’ attention that one of the contributing authors was left off of the paper. The authors apologize for the unfortunate oversight. In this correction paper, they have included
Externí odkaz:
https://doaj.org/article/3b997d76283747e692ebd2a25185f948
Jonathan Edwards (1703-1758) is early Americas greatest theologian and philosopher, yet six decades have passed since an authoritative anthology of his writings has appeared to guide the reader through his voluminous works. This book is a new and com
Autor:
Thomas C. Irving, Zaynab Hourani, John E. Smith, Weikang Ma, Paola Tonino, Johan Lindqvist, Josh Strom, Henk Granzier, Frank Li, Coen A.C. Ottenheijm, Esmat Karimi, Henry Gong, Robbert van der Pijl, Yaeren Hernandez, Balázs Kiss, Justin Kolb
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, 11(1):2699. Nature Publishing Group UK
Lindqvist, J, Ma, W, Li, F, Hernandez, Y, Kolb, J, Kiss, B, Tonino, P, van der Pijl, R, Karimi, E, Gong, H, Strom, J, Hourani, Z, Smith, J E, Ottenheijm, C A C, Irving, T & Granzier, H 2020, ' Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism ', Nature Communications, vol. 11, no. 1, 2699 . https://doi.org/10.1038/s41467-020-16526-9
Nature Communications
Nature Communications, 11(1):2699. Nature Publishing Group UK
Lindqvist, J, Ma, W, Li, F, Hernandez, Y, Kolb, J, Kiss, B, Tonino, P, van der Pijl, R, Karimi, E, Gong, H, Strom, J, Hourani, Z, Smith, J E, Ottenheijm, C A C, Irving, T & Granzier, H 2020, ' Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism ', Nature Communications, vol. 11, no. 1, 2699 . https://doi.org/10.1038/s41467-020-16526-9
Nature Communications
Nebulin is a giant protein that winds around the actin filaments in the skeletal muscle sarcomere. Compound-heterozygous mutations in the nebulin gene (NEB) cause typical nemaline myopathy (NM), a muscle disorder characterized by muscle weakness with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::158f7f53cf1a448aeb85bc5d60978071
http://link.springer.com/article/10.1038/s41467-020-16526-9
http://link.springer.com/article/10.1038/s41467-020-16526-9
Autor:
John E. Smith, Henk Granzier, Gerrie P. Farman, Joshua Strom, Mei Methawasin, Shawtarohgn Granzier-Nakajima
Publikováno v:
Circulation Research. 129
Titin’s C-zone is the inextensible part of titin that binds along the thick filament at its cMyBP-C -containing region. Previously it was shown that deletion of titin’s super-repeats C1 and C2 ( Ttn ΔC1-2 mouse model) results in shorter thick fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::970a9676ee5157e58252ae07325fb199
https://doi.org/10.1161/res.129.suppl_1.p315
https://doi.org/10.1161/res.129.suppl_1.p315
Publikováno v:
Disaster Medicine and Public Health Preparedness. 14:568-576
Objectives:Civil–military relationships are necessary in humanitarian emergencies but, if poorly managed, may be detrimental to the efforts of humanitarian organizations. Awareness of guidelines and understanding of risks relating to the relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200eaaff22060759d913accbda5d0f50
https://doi.org/10.1017/dmp.2019.76
https://doi.org/10.1017/dmp.2019.76