Zobrazeno 1 - 10
of 456
pro vyhledávání: '"John E Shively"'
Development and characterization of DIA 12.3, a fully human intact anti-CEACAM1 monoclonal antibody.
Autor:
Michela Centonze, Valentina Fiori, Maciej Kujawski, Lin Li, Patty Wong, Lindsay Williams, Tomas Di Mambro, Sabrina Dominici, Angelo Sparti, John E Shively, Mauro Magnani
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0295345 (2024)
Carcinoembryonic antigen cell adhesion molecule-1 (CEACAM1), a homotypic cell adhesion molecule glycoprotein with apical expression on normal epithelial cells and activated lymphocytes, is overexpressed on many tumors and acts as an inhibitory recept
Externí odkaz:
https://doaj.org/article/b51ad4ff63384ac8a4df3e97495290ac
Autor:
Zhifang Zhang, Jinong Feng, Allen Mao, Keith Le, Deirdre La Placa, Xiwei Wu, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Susan L Neuhausen, John E Shively
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198625 (2018)
BACKGROUND:Fibromyalgia (FM) is a chronic pain syndrome with a high incidence in females that may involve activation of the immune system. We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide famil
Externí odkaz:
https://doaj.org/article/18158d42ee0e4c9ea6ff91e1a6e5d97f
Autor:
Shozo Yokoyama, Akihiro Takeuchi, Shunsuke Yamaguchi, Yasuyuki Mitani, Takashi Watanabe, Kenji Matsuda, Tsukasa Hotta, John E Shively, Hiroki Yamaue
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183337 (2017)
Serum exosomal proteins have great potential as indicators of disease status in cancer, inflammatory or metabolic diseases. The association of a fraction of various serum proteins such as carcinoembryonic antigen (CEA) with circulating exosomes has b
Externí odkaz:
https://doaj.org/article/0c7c8fe1614f4740a9bd3d26effb04df
Autor:
Stefanie Nittka, Marcel A Krueger, John E Shively, Hanne Boll, Marc A Brockmann, Fabian Doyon, Bernd J Pichler, Michael Neumaier
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106921 (2014)
PurposeColorectal cancer is one of the most common forms of cancer, and the development of novel tools for detection and efficient treatment of metastases is needed. One promising approach is the use of radiolabeled antibodies for positron emission t
Externí odkaz:
https://doaj.org/article/f4d8f5b6c107497e9e59e53fde960aa2
Autor:
Zhifang Zhang, John E Shively
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67649 (2013)
An incomplete understanding of bone forming cells during wound healing and ectopic calcification has led to a search for circulating cells that may fulfill this function. Previously, we showed that monoosteophils, a novel lineage of calcifying/bone-f
Externí odkaz:
https://doaj.org/article/d98b80ccf5234c64bf28dd1cac058bed
Autor:
Kay O Johswich, Shannon E McCaw, Epshita Islam, Anna Sintsova, Angel Gu, John E Shively, Scott D Gray-Owen
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003509 (2013)
Neisseria meningitidis (Nme) asymptomatically colonizes the human nasopharynx, yet can initiate rapidly-progressing sepsis and meningitis in rare instances. Understanding the meningococcal lifestyle within the nasopharyngeal mucosa, a phase of infect
Externí odkaz:
https://doaj.org/article/28b69d61c05c4a48b334e922729c1b40
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53359 (2013)
CEACAM20, a novel member of the CEACAM1 gene family with expression limited to the lumen of small intestine, testes, and prostate, is co-expressed with CEACAM1 in adult prostate tissue and down-regulated to the same extent as CEACAM1 in prostate canc
Externí odkaz:
https://doaj.org/article/93debf6a4df5415785dbaf32fe85ae0d
Autor:
Mary M Zheng, Zhifang Zhang, Kyle Bemis, Andrew R Belch, Linda M Pilarski, John E Shively, Julia Kirshner
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58504 (2013)
Multiple myeloma (MM) is an incurable bone marrow malignancy of the B cell lineage. Utilizing multiplex Luminex technology we measured levels of 25 cytokines in the plasma of normal donors (n = 177), those with monoclonal gammopathy of undetermined s
Externí odkaz:
https://doaj.org/article/c3bef10258664c6bb928a4460b4e9946
Autor:
Jinong Feng, Zhifang Zhang, Xiwei Wu, Allen Mao, Frances Chang, Xutao Deng, Harry Gao, Ching Ouyang, Kenneth J Dery, Keith Le, Jeffrey Longmate, Claudia Marek, R Paul St Amand, Theodore G Krontiris, John E Shively
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65033 (2013)
Fibromyalgia syndrome (FMS) is a chronic musculoskeletal pain disorder affecting 2% to 5% of the general population. Both genetic and environmental factors may be involved. To ascertain in an unbiased manner which genes play a role in the disorder, w
Externí odkaz:
https://doaj.org/article/2ff97d673efd43b6a50dde75bb829eb9
Publikováno v:
PLoS Pathogens, Vol 8, Iss 4, p e1002597 (2012)
LPS-activated neutrophils secrete IL-1β by activation of TLR-4. Based on studies in macrophages, it is likely that ROS and lysosomal destabilization regulated by Syk activation may also be involved. Since neutrophils have abundant expression of the
Externí odkaz:
https://doaj.org/article/ef3d6ea10f64436b972fdbb9ab0fad94